CRBN ligand-396 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular systems. This compound can be coupled with a ligand targeting a specific protein through a suitable linker to create a proteolysis-targeting chimera (PROTAC). It allows for targeted degradation of proteins, enabling nuanced investigations into protein function and regulation. Key applications include the study of ubiquitin-proteasome pathway mechanisms and protein homeostasis.
CRBN ligand-396 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular systems. This compound can be coupled with a ligand targeting a specific protein through a suitable linker to create a proteolysis-targeting chimera (PROTAC). It allows for targeted degradation of proteins, enabling nuanced investigations into protein function and regulation. Key applications include the study of ubiquitin-proteasome pathway mechanisms and protein homeostasis.
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