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CRBN ligand-429

Ligand for E3 Ligase

CRBN ligand-429 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation applications. This compound can be effectively conjugated to a target protein ligand using a linker, enabling the formation of PROTAC (proteolysis-targeting chimeras) molecules. It serves as a valuable tool in the study of targeted degradation pathways and has potential utility in therapeutic research focused on modulating protein levels within cellular systems.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925073-31-8
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₁N₃O₃
Molecular Weight	269.26
SMILES	O=CC=1C=C2N=CC=CC2=C(C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.