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CRBN ligand-300

Ligand for E3 Ligase

CRBN ligand-300 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively conjugated to a target protein ligand using a linker to generate a Proteolysis Targeting Chimera (PROTAC). Its application is significant in studies focused on targeted protein degradation and pharmacological interventions in various biological systems.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2357110-72-4
Applications	Ligand for E3 Ligase
Formula	C₁₂H₉BrN₂O₄
Molecular Weight	325.12
SMILES	O=C1OC=2C(Br)=CC=CC2N1C3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.