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2-(1-(Boc)Piperidin-4-yl)-2,2-difluoroacetic acid

PROTAC Linker

2-(1-(Boc)Piperidin-4-yl)-2,2-difluoroacetic acid serves as a versatile PROTAC linker essential for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases, enabling targeted degradation of specific proteins within cellular pathways. Its application is crucial in the development of innovative therapeutic strategies for diseases related to protein dysregulation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1258638-62-8
Applications	PROTAC Linker
Formula	C₁₂H₁₉F₂NO₄
Molecular Weight	279.28
SMILES	O=C(OC(C)(C)C)N1CCC(CC1)C(F)(F)C(=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.