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(S,R,S)-AHPC-PEG2-NHS ester

PROTAC Linker

(S,R,S)-AHPC-PEG2-NHS ester is a synthetic linker designed for use in PROTAC (Proteolysis Targeting Chimera) applications. Its structure features an E3 ligase ligand coupled with a polyethylene glycol (PEG) spacer, enhancing solubility in aqueous environments. The reactive NHS ester functional group allows for efficient conjugation with amine-containing compounds, facilitating the development of targeted protein degradation strategies in chemical biology research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2757045-58-0
Applications	PROTAC Linker
Formula	C₃₄H₄₅N₅O₁₀S
Molecular Weight	715.81
SMILES	O=C(CCC1=O)N1OC(CCOCCOCCC(NC(C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.