(S,R,S)-AHPC-PEG2-NHS ester

Catalog No.: A83964
PROTAC Linker
(S,R,S)-AHPC-PEG2-NHS ester is a synthetic linker designed for use in PROTAC (Proteolysis Targeting Chimera) applications. Its structure features an E3 ligase ligand coupled with a polyethylene glycol (PEG) spacer, enhancing solubility in aqueous environments. The reactive NHS ester functional group allows for efficient conjugation with amine-containing compounds, facilitating the development of targeted protein degradation strategies in chemical biology research.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S,R,S)-AHPC-PEG2-NHS ester is a synthetic linker designed for use in PROTAC (Proteolysis Targeting Chimera) applications. Its structure features an E3 ligase ligand coupled with a polyethylene glycol (PEG) spacer, enhancing solubility in aqueous environments. The reactive NHS ester functional group allows for efficient conjugation with amine-containing compounds, facilitating the development of targeted protein degradation strategies in chemical biology research.
Product Information
Catalog NumA83964
FormulaC34H45N5O10S
Molecular Weight715.81
CAS Number2757045-58-0
SMILESO=C(CCC1=O)N1OC(CCOCCOCCC(NC(C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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