Fig. 1 · Structure
Documents & Downloads
Fmoc-PEG6-NHS ester
PROTAC Linker
Fmoc-PEG6-NHS ester is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of E3 ligase ligands with target proteins, enabling targeted protein degradation. This compound is essential for research in pharmacology, particularly in the development of innovative therapeutic strategies that leverage the ubiquitin-proteasome system.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1818294-31-3 |
| Applications | PROTAC Linker |
| Formula | C34H44N2O12 |
| Molecular Weight | 672.72 |
| SMILES | O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.