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Active-mono-sulfone-PEG8-acid

PROTAC Linker

Active-mono-sulfone-PEG8-acid is a PEG-based linker designed for use in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target ligands to E3 ligase components, thereby promoting targeted protein degradation. It offers significant potential in various biological research applications, including drug discovery and therapeutic development, by optimizing the spatial arrangement for effective and selective ubiquitination.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2055048-45-6
Applications	PROTAC Linker
Formula	C₃₇H₅₃NO₁₄S
Molecular Weight	767.88
SMILES	O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(C1=CC=C(C(C(CS(=O)(C2=CC=C(C)C=C2)=O)=C)=O)C=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.