Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
5α-Cholestan-3-one is an endogenous metabolite primarily involved in cholesterol metabolism. This compound serves as a crucial intermediate in the biosynthesis of steroid hormones and is important for investigating lipid-related metabolic pathways. Its biological activity is significant in studies related to metabolic disorders and hormonal regulation. -
Endogenous Metabolite
3-Methyl-2-buten-1-ol is an endogenous metabolite that modulates physiological processes in various biological systems. This compound exhibits potential weight reduction effects, as evidenced by studies demonstrating its efficacy in animal models. It is primarily utilized in research applications related to metabolism and may hold significance for studies on fragrance compounds due to its presence in pine trees. -
Endogenous Metabolite
19-Hydroxyandrost-4-ene-3,17-dione serves as a substrate for the enzymes Corticotropin-lipotropin and Cytochrome P450 19A1. This endogenous metabolite plays a crucial role in steroidogenesis and is valuable in studies of adrenal and gonadal function. Its utility extends to research on hormone biosynthesis and the physiological effects of androgens and estrogens. -
Endogenous Metabolite
D-Threitol functions as an endogenous metabolite and plays a critical role in cryoprotection. Its primary biological activity includes acting as an antifreeze agent in organisms such as the Alaskan beetle Upis ceramboides. This compound is of interest in studies investigating metabolic adaptations to extreme cold environments and cellular responses to stress conditions. -
Endogenous Metabolite
Ac-DL-Trp-OH is an endogenous metabolite that serves as a precursor in the biosynthesis of various tryptophan-derived compounds. This compound is utilized in studies focused on metabolic pathways and neurotransmitter synthesis, particularly in relation to serotonin and melatonin production. Its application extends to research involving tryptophan metabolism and related phenotypic effects in biological systems. -
Endogenous Metabolite
L-Cysteic acid monohydrate is an endogenous metabolite and the oxidation product of L-cystine. It serves as a substrate for glutamate decarboxylase (GADCase) and cysteine sulfinic acid decarboxylase (CADCase II), playing a crucial role in neurotransmitter synthesis. This compound is valuable for research into amino acid metabolism and neurological function. -
Endogenous Metabolite
3-Furanoic acid is an endogenous metabolite known for its anti-inflammatory properties. It and its derivatives can modulate inflammation-related signaling pathways and inhibit the proliferation of synovial fibroblasts, thereby exerting significant immunomodulatory effects. This compound is valuable for research in inflammation, autoimmune disorders, and related therapeutic developments. -
Endogenous Metabolite
3-Methoxybenzoic acid is an endogenous metabolite that exhibits the ability to form complexes with metal ions, including europium (III) and gadolinium (III). It is known to undergo metabolism by anaerobic bacteria primarily through an O-demethylation mechanism. This compound is utilized in studies involving metal ion coordination and investigations into microbial metabolic pathways. -
Endogenous Metabolite
Cyclohexaneacetic acid serves as an endogenous metabolite involved in the metabolic pathways of n-alkylcyclohexanes (nACH) in microorganisms. This compound can be metabolized into monohydroxycyclohexaneacetic acids by various strains of Chlorella pyrenoidosa. Its biological activity makes it relevant for studies focusing on microbial metabolism and environmental biochemistry. -
Endogenous Metabolite
DL-Glutamic acid is the conjugate acid of glutamic acid, functioning as a key endogenous metabolite. It plays a critical role in various biochemical pathways, including neurotransmission and metabolic processes. Compared to the α and β polymorphs of L-Glutamic acid, DL-Glutamic acid exhibits enhanced stability, making it a valuable reagent for research applications in biochemistry and neurobiology. -
Endogenous Metabolite
Isomaltulose hydrate is an endogenous carbohydrate metabolite. It serves as a source of energy through enzymatic hydrolysis and plays a role in metabolic processes. This compound is useful in research related to energy metabolism, glycemic response, and the exploration of dietary carbohydrates' impact on health. -
Endogenous Metabolite
Undecanedioic acid is an endogenous metabolite that plays a significant role in the structural integrity of intercellular matrix macromolecules, particularly elastin. Its biological activity is essential for studying extracellular matrix dynamics, cellular interactions, and tissue elasticity. This compound is valuable in research applications focusing on connective tissue disorders and metabolic studies related to elastin synthesis and degradation. -
Endogenous Ceramide
C14 Ceramide (d18:1/14:0) is an endogenous ceramide synthesized by ceramide synthetase 6. This compound plays a critical role in various cellular processes, including apoptosis and inflammation. It holds significant potential for research applications in the fields of neurodegenerative diseases, such as Parkinson's disease, and metabolic disorders like diabetes, providing insights into lipid signaling pathways and their implications in disease mechanisms. -
Endogenous metabolites
AAMU (5-Acetylamino-6-amino-3-methyluracil) is a key endogenous metabolite of caffeine, predominantly found in human biological systems. This compound is important for studying caffeine metabolism and its biological effects. AAMU serves as a valuable biomarker in research focused on caffeine's role in various physiological processes and may aid in understanding its impact on health. -
Endogenous Metabolite
Oxaloacetic acid-13C4 is the stable isotopically labeled form of oxaloacetic acid, a key endogenous metabolite. This compound plays a critical role as a metabolic intermediate in the citric acid cycle, gluconeogenesis, urea cycle, glyoxylate cycle, and various biosynthetic pathways, including amino acid and fatty acid synthesis. Oxaloacetic acid-13C4 is essential for tracing metabolic dynamics in biological research and can be utilized in studies involving metabolic flux analysis and the assessment of metabolic pathways. -
Endogenous Metabolite
H-Trp-NH2.HCl, a derivative of tryptophan, functions primarily as an endogenous metabolite involved in various biochemical pathways. It plays a significant role in metabolic processes and can be utilized in research applications focused on amino acid metabolism and neurotransmitter synthesis. This compound is valuable for studies investigating the physiological effects of tryptophan derivatives in cellular and molecular biology. -
Endogenous Metabolite
Ethyl arachidonate is an esterified form of arachidonic acid, functioning as a lipophilic endogenous metabolite. It serves as a source of exogenous arachidonate in dietary regimens and cell culture, facilitating studies on fatty acid metabolism. Notably, ethyl arachidonate is the predominant fatty acid ethyl ester found in the brains of individuals with alcohol intoxication, making it relevant for research into alcohol-related neurobiology. -
Endogenous Metabolite
Decyl aldehyde is a ten-carbon aldehyde that functions as a substrate for bacterial luciferase. This compound serves as an important endogenous metabolite in various biological systems. It is utilized in research applications focused on bioluminescence and metabolic studies, offering insights into cellular processes and enzyme activity. -
Herbicide
Fluorodifen is a selective herbicide that disrupts photosynthesis and growth hormone regulation in plants. This compound effectively inhibits the growth of a wide range of annual and perennial broadleaf weeds, as well as certain grass weeds. Its primary applications include the management of weed populations in various agricultural settings, contributing to improved crop yields and health. -
Endogenous Metabolite
NPD7155 is a purine-based competitive inhibitor of the enzyme MTH1, which plays a crucial role in the detoxification of oxidized purine metabolites. This compound demonstrates significant cytotoxic activity against cancer cells by promoting oxidative stress and disrupting metabolic pathways. NPD7155 is valuable for research into the mechanisms of cancer cell metabolism and the development of targeted cancer therapies. -
Endogenous Metabolite
Butaperazine dimaleate is an antipsychotic compound that serves as a reactive agent for the detection of vanadium (V). This reagent undergoes a reaction in phosphoric acid medium, resulting in the formation of a red radical cation that exhibits a maximum absorption at 513 nm. It follows Beer's law, applicable for concentrations ranging from 0.25 to 5.0 μg/ml, with a sensitivity of 6.1 ng/cm2. Butaperazine dimaleate is ideal for the analysis of vanadium in steel, minerals, biological samples, and soil. -
Endogenous Metabolite
8-(3-Chlorostyryl)caffeine is a selective antagonist of the A2a adenosine receptor, demonstrating a significant 520-fold selectivity in radioligand binding assays conducted in rat brain. It effectively inhibits adenylylase with a 22-fold selectivity in rat chromaffin cells. Co-administration with the A1-selective antagonist CPX has been shown to enhance exercise activity. Additionally, 8-(3-Chlorostyryl)caffeine exhibits potent inhibitory activity against MAO-B in primate mitochondrial systems. This compound serves as a valuable tool for studying adenosine receptor signaling and its effects on physiological processes. -
Endogenous Metabolite
Tetracosanoyl-sulfatide is an endogenous metabolite that serves as a significant molecular marker in various biological processes. Its primary role in the research of Mild Metachromatic Leukodystrophy allows for the investigation of lipid metabolism and myelin degradation. This metabolite is valuable for studying the pathophysiology of lysosomal storage disorders and for developing potential diagnostic tools and therapeutic strategies. -
Endogenous Metabolite
11-trans-Leukotriene C4 is a derivative of trans-Leukotriene C4 (LTC4) and functions as an important endogenous metabolite involved in inflammatory responses. It plays a crucial role in mediating allergic reactions and is implicated in various pathological conditions associated with inflammation. This compound is valuable for research related to inflammation, allergy, asthma, and other diseases where leukotrienes contribute to disease pathology. -
Endogenous Metabolite
Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is an endogenous metabolite of vitamin D3 with significant biological activity in bone health, cell differentiation, and immune function. As the active form of vitamin D, it is involved in regulating calcium and phosphate metabolism, thereby influencing various physiological processes. Calcitriol lactone is utilized in research to study vitamin D signaling pathways and their implications in bone disorders and immune responses. -
Endogenous Metabolite
N4-Acetylsulfamethazine is a metabolite of sulfamethazine, a widely utilized sulfonamide in veterinary medicine, specifically within the poultry farming sector. This compound serves as an endogenous metabolite, playing a role in the metabolic pathway of sulfonamides. It is relevant for research applications focusing on drug metabolism, residues in livestock, and the environmental impact of veterinary pharmaceuticals. -
Endogenous Metabolite
Metoprolol acid is an endogenous metabolite of the beta-blocker metoprolol. Although it does not exhibit pharmacological activity, it serves as a useful biomarker for studying the metabolism and pharmacokinetics of metoprolol in various biological samples. Researchers can detect metoprolol acid using solid phase extraction coupled with reversed phase high-performance liquid chromatography, employing fluorescence detection and specific eluents to ensure accurate analysis. -
Fungal Metabolite
Epicoccamide is a tetramic acid derivative that serves as a secondary metabolite derived from the fungus Epicoccum purpurascens. This compound exhibits antifungal properties, making it a valuable tool for researching fungal biology and exploring potential therapeutic applications in mycology. Its unique structure and biological activity offer insights into fungal metabolite functions and their interactions within ecological systems. -
Endogenous Metabolite
(S)-Higenamine, an endogenous metabolite and S-enantiomer of Higenamine, is a key precursor in the biosynthesis of benzylisoquinoline alkaloids. It is synthesized through the condensation of dopamine with 4-hydroxyphenylacetaldehyde via the enzyme norcoclaurine synthase. This compound plays a significant role in various biological activities, making it valuable for research in neurobiology and pharmacology. -
Endogenous Metabolite
STF-038533 is an inhibitor of the cAMP response element-binding protein (CREB), primarily targeting its transcriptional activity. This compound effectively suppresses the expression of CREB target genes, thereby modulating cellular signaling pathways. STF-038533 is invaluable for research into diseases associated with aberrant CREB activity, offering insights into therapeutic strategies for CREB-related disorders. -
Endogenous Metabolite
Pinoxepin hydrochloride is an antipsychotic compound primarily targeting neuropsychiatric conditions. It exhibits sedative and antidepressant properties, making it valuable in the study of mental disorders such as schizophrenia and depression. Additionally, Pinoxepin hydrochloride has been noted for its potential to enhance sleep quality, contributing to its utility in related research applications. -
Endogenous Metabolite
RI-61 is an endogenous metabolite that modulates neurotransmitter activity. This compound exhibits significant efficacy in alleviating symptoms associated with migraine, cluster headache, new daily persistent headache, and cyclical vomiting syndrome. Research applications include the study of pain mechanisms and therapeutic approaches for headache disorders. -
Endogenous Metabolite
Deleobuvir sodium is a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase, targeting viral replication. This compound exhibits significant anti-hepatitis C virus activity, making it a valuable tool for research into hepatitis C treatment. Its use facilitates the study of viral mechanisms and the development of therapeutic strategies aimed at combating hepatitis C infection. -
Endogenous Metabolite
11-trans Leukotriene E4 is an isomer of the endogenous metabolite Leukotriene E4 (LTE4) and functions primarily as a potent bronchoconstrictor. It exhibits equipotent activity to LTE4 in inducing contractions in guinea pig ileum. This compound is valuable for research into leukotriene pathways, inflammatory responses, and respiratory disorders. -
Fungal Metabolite
Neoechinulin C is a fungal metabolite belonging to the indolediketopiperazine alkaloid class. It exhibits protective effects on neuronal cells against paraquat-induced damage, making it a valuable compound for research related to neurodegenerative diseases such as Parkinson's disease. This compound is useful in studying mechanisms of cell protection and potential therapeutic strategies in neurobiology. -
Endogenous Metabolite
Bendiocarb is a carbamate compound that primarily acts as an inhibitor of the enzyme acetylcholinesterase. This inhibition results in increased levels of acetylcholine, which plays a crucial role in neurotransmission and muscle contraction. Bendiocarb is utilized in research applications focusing on neurobiology and the study of cholinergic systems, as well as in the examination of potential neurotoxic effects. -
Endogenous Metabolite
SKF 103784 is a vasopressin antagonist that targets the action of vasopressin, inhibiting its physiological effects linked to antidiuresis. This compound is valuable for investigating biological processes related to water and sodium homeostasis. Furthermore, SKF 103784 can be utilized in research to elucidate pathological mechanisms associated with cardiovascular diseases and endocrine disorders. -
Endogenous Metabolite
H-0106 dihydrochloride is a selective inhibitor of Rho-associated kinase (ROCK), primarily targeting the modulation of intraocular pressure (IOP). This compound exhibits significant IOP-lowering activity, as demonstrated in primate models. Research indicates that while H-0106 dihydrochloride effectively inhibits the ROCK enzyme, the relationship between ROCK inhibition and IOP reduction may not be straightforward, warranting further investigation into its mechanisms of action in ocular health. -
Endogenous Metabolite
3-(2-Aminopropyl)phenol is an endogenous metabolite known for its ability to elevate blood pressure. This compound has been shown to effectively alleviate symptoms of orthostatic hypotension in patients, significantly increasing blood pressure both at rest and upon standing after oral administration. Additionally, 3-(2-Aminopropyl)phenol may aid in mitigating pathological orthostatic adjustment disorders with minimal impact on heart rate and a favorable side effect profile. These properties make it a valuable tool for researching blood pressure regulation and related disorders. -
Fungal Metabolite
Berninamycin D is a cyclic peptide fungal metabolite that exhibits potent antifungal activity. Isolated from the fermentation of Streptomyces bernensis, this compound serves as an important tool in studying antifungal mechanisms and microbial interactions. It is applicable in various research settings focused on fungal pathogenesis and the development of new antifungal therapeutics. -
Endogenous Metabolite
(Rac)-Eflucimibe is an ACAT inhibitor that modulates endogenous hypercholesterolemia. It demonstrates significant potency and efficacy as an anti-hypercholesterol agent in various animal models of hypercholesterolemia. This compound is useful for investigating cholesterol metabolism and understanding the mechanisms of cholesterol regulation in biological systems. -
Endogenous Metabolite
Phenolic acid is an endogenous metabolite that plays a crucial role in various biochemical processes. Known for its antioxidant properties, it participates in the modulation of cellular signaling pathways and has implications in metabolic regulations. This compound is widely utilized in research exploring oxidative stress, inflammation, and metabolic disorders. -
Endogenous Metabolite
1,2-Dioleoyl-3-lauroyl-rac-glycerol is a triglyceride that serves as an endogenous metabolite, widely studied for its structural and distribution characteristics in various biological matrices. It has been identified in human milk, infant formula, and both mammalian and vegetable oils. This compound is useful in research focusing on lipid metabolism, nutrition, and the biochemical composition of milk fats. -
Endogenous Metabolite
DBPR110 is a potent inhibitor of nonstructural protein 5A (NS5A), specifically targeting hepatitis C virus (HCV) replication. It demonstrates significant antiviral activity with an EC50 of 3.9 ± 0.9 pM against HCV1b replicon reporter expression, and a selectivity index exceeding 12,800,000. Additionally, DBPR110 reduces HCV2a replicon activity with an EC50 of 228.8 pM and a selectivity index of over 173,130. This compound exhibits synergistic effects when used in combination with interferon alpha (IFN-α) and other antiviral agents, suggesting its potential as a viable small molecule therapeutic for HCV treatment. -
Endogenous Metabolite
FPL-55712 is a cysteine leukotriene type 1 receptor antagonist that exhibits anti-inflammatory effects. This compound effectively inhibits the biological responses induced by leukotrienes, thereby reducing allergic reactions and alleviating airway inflammation. FPL-55712 holds promise for research applications related to asthma and allergic rhinitis management. -
Endogenous Metabolite
AHR Activator 1 is an aryl hydrocarbon receptor (AHR) activator that modulates fibroblast growth factor-2 (FGF2)-induced branching morphogenesis. It functions by inhibiting AHR signaling, thereby preventing cellular branch formation. Additionally, AHR Activator 1 interacts with dissociated linkers, highlighting their significance in the inhibitory effects of AHR agonists on branching. This compound is valuable for studying mammary gland morphogenesis and understanding the mechanisms underlying FGF-induced invasion. -
Endogenous Metabolite
Muscarinic agonist 1 (AF267) targets muscarinic acetylcholine receptors, which are vital for cognitive function. This compound exhibits potential in alleviating cognitive impairments, making it a valuable tool for research into neurodegenerative diseases and cognitive disorders. Its mechanism of action provides insight into cholinergic signaling and its role in cognitive processes, thus serving as a significant reagent in neuroscience studies. -
Fungal Metabolite
Aspericin C is a pyran derivative derived from the marine fungus Rhizopus sp. 2-PDA-61. This compound exhibits cytotoxic effects against various cancer cell lines, including P388, A549, HL-60, and BEL-7420, with IC50 values of 14.6, 7.1, 61.4, and 24.2 μM, respectively. Aspericin C serves as a valuable tool for researching antitumor activity and the mechanisms underlying cytotoxicity in cancer biology. -
Endogenous Metabolite
YM471 free base is a selective non-peptide antagonist targeting vasopressin V1A and V2 receptors. It demonstrates high affinity for these receptors in rat models, with binding affinities (K values) of 0.16 nM for V1A and 0.77 nM for V2. This compound is valuable for investigating the role of vasopressin receptors in various physiological and pathological conditions. -
Endogenous Metabolite
(S)-CPP sodium is an inhibitor of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, also known as BDK. By negatively regulating BCKDC activity, (S)-CPP effectively activates the complex and significantly reduces plasma concentrations of branched-chain amino acids such as leucine, isoleucine, and valine in wild-type mice. This agent is useful for research applications investigating metabolic pathways and the regulation of amino acid levels in physiological and pathological contexts.
