Fig. 1 · Structure
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XR5944
Cat. No.
A72392
CAS
343247-32-5
Endogenous Metabolite
XR5944 is a potent topoisomerase inhibitor that targets DNA, demonstrating significant anti-tumor activity. It effectively inhibits the activities of both topoisomerase I and II, showcasing impressive potency across various cell lines, with IC50 values ranging from 0.04 to 0.4 nM. XR5944 remains effective in overcoming atypical drug resistance mechanisms, including cells overexpressing P-glycoprotein and multidrug resistance-related proteins. This compound has shown remarkable anti-tumor efficacy in preclinical models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in multiple cases. XR5944 is valuable for research on colon and lung cancer biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 343247-32-5 |
| Applications | Endogenous Metabolite |
| Formula | C34H34N8O2 |
| Molecular Weight | 586.69 |
| SMILES | O=C(C1=CC=CC2=NC3=CC=CC(C)=C3N=C21)NCCNCCNCCNC(C4=CC=CC5=NC6=CC=CC(C)=C6N=C54)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.