Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
KSD 2405 is an endogenous metabolite that plays a significant role in various biochemical pathways. This compound is involved in metabolic processes and may influence cellular function and signaling. Its application in research includes the study of metabolic disorders, physiological regulation, and potential therapeutic interventions. -
Fungal Metabolite
Cerebroside D is a glycoceramide compound known for its immunomodulatory properties. It has been shown to enhance recovery from experimental colitis in mouse models, primarily through the modulation of activated T lymphocytes. This compound is of particular interest in research related to autoimmune diseases and inflammation. -
Endogenous Metabolite
SEP-227900 is a potent and orally bioavailable inhibitor of D-amino acid oxidase (DAO). It exhibits significant biological activity that may benefit conditions related to vitamin D metabolism and sunlight exposure. This compound holds promise for enhancing cancer prognosis and is applicable in research focusing on metabolic pathways and related diseases. -
Endogenous Metabolite
5-Methoxysalicylic acid (5-MeOSA) is an endogenous metabolite known for its role as a matrix in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis of oligonucleotides. When combined with spermine, 5-MeOSA enhances ionization efficiency, making it a valuable tool in biochemical research. Its applications extend to studying nucleic acid interactions and characterizing oligonucleotide structures, thereby facilitating advancements in genetic and molecular biology studies. -
Endogenous Metabolite
Dapagliflozin-3-O-β-D-glucuronide is an endogenous metabolite of Dapagliflozin, produced primarily by the enzyme uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9) in the liver and kidney. This compound plays a crucial role in the pharmacokinetics of Dapagliflozin, a selective inhibitor of sodium-glucose co-transporter 2 (SGLT2), which is utilized for improving glycemic control in type 2 diabetes management. Its study is significant in understanding drug metabolism and therapeutic efficacy in diabetic conditions. -
Endogenous Metabolite
Dihomo-γ-linolenic acid sodium is an endogenous metabolite classified as a 20-carbon ω-6 fatty acid. It exhibits notable anti-inflammatory and anti-proliferative activities, making it relevant for research involving lipid metabolism and cellular signaling. Notably, DGLA sodium has been shown to attenuate atherosclerosis in apolipoprotein E-deficient mouse models, highlighting its potential in cardiovascular research and inflammation studies. -
Fungal Metabolite
(-)-Cyclopenol is a fungal metabolite derived from the Australian marine fungus Aspergillus versicolor (MST-MF495). This compound exhibits significant biological activity, particularly in the inhibition of specific fungal species. It serves as a valuable tool for studying fungal metabolism and exploring potential antifungal applications in research. -
Endogenous Metabolite
6-Dehydroprogesterone is an endogenous metabolite derived from the microbial dehydrogenation of progesterone. This steroid compound is significant for studying steroid metabolism pathways, including microbial dehydrogenase activity and steroid biotransformation. Its unique properties make it a valuable tool for researchers investigating the biochemical roles of steroid metabolites. -
Endogenous Metabolite
13-cis-Retinyl acetate is a metabolite of vitamin A, specifically an active isomer derived from Retinyl acetate. This compound is known to play a significant role in various biological processes, including vision and cellular growth regulation. Its unique structure and activity make it a valuable tool for research applications studying vitamin A metabolism and its physiological effects. -
Endogenous Metabolite
Cyclanilide, an endogenous metabolite, acts as a plant growth regulator primarily used in cotton cultivation. It influences various growth stages by modulating physiological processes, which can enhance crop yield and quality. Its applicability in agricultural research makes it a valuable tool for exploring plant growth dynamics and metabolism. -
Endogenous Metabolite
4,4'-Disulfanediylbis(2-aminobutanoic acid) is an endogenous metabolite that plays a crucial role in various biochemical pathways. It serves as a potential biomarker in metabolic studies, enabling researchers to investigate redox states and sulfur metabolism. This compound is valuable for research applications focused on metabolic regulation and cellular signaling. -
Endogenous Metabolite
18-Hydroxycorticosterone is a corticosteroid and an endogenous metabolite derived from corticosterone. It plays a crucial role in the regulation of electrolyte balance and blood pressure. This compound is essential for research into adrenal gland function, mineralocorticoid activity, and conditions associated with electrolyte disturbances, such as hyperaldosteronism. -
Endogenous Metabolite
1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine is an endogenous metabolite that plays a crucial role in lipid metabolism. It is primarily involved in signaling pathways related to obesity and metabolic disorders. This compound can be utilized in research to investigate the biological mechanisms underlying obesity and its potential impact on health. -
Endogenous Metabolite
Cortisol sulfate, also known as Cortisol 21-sulfate, is an endogenous metabolite of cortisol. As a specific ligand for intracellular transcortin, it plays a crucial role in regulating corticosteroid activity within the body. This compound is instrumental in research applications focused on stress response, glucocorticoid signaling, and metabolic pathways related to endocrine function. -
Endogenous Metabolite
Triarachidin is an endogenous metabolite that plays a significant role in the biosynthesis of lipids and other cellular functions. As a bioactive compound, it contributes to various metabolic pathways and cellular signaling mechanisms. Triarachidin is essential for research related to lipid metabolism, cellular physiology, and the exploration of metabolic disorders. -
Endogenous Metabolite
Lucidenic acid LM1 is a natural triterpenoid derived from the fungus Ganoderma lucidum. It is an endogenous metabolite that exhibits various biological activities, including anti-inflammatory and antioxidant properties. This compound has potential applications in research focused on oxidative stress, inflammation, and the exploration of fungal bioactive substances. -
Endogenous Metabolite
Phenylacetyl CoA is an endogenous metabolite that serves as an acyl-CoA derivative in metabolic pathways. It functions as a substrate for acceptor oxidoreductases, playing a critical role in the anaerobic metabolism of phenylalanine in denitrifying bacteria, such as Thauera aromatica. This compound is essential for studies on microbial metabolism and can be applied in research investigating the enzymatic processes of anaerobic organisms. -
Endogenous Metabolite
Urolithin M7 is an endogenous metabolite derived from gut microbiota metabolism. It exhibits significant inhibitory effects on oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is a valuable reagent for research applications focused on gut microbiota metabolism and cardiovascular disease mechanisms. -
Endogenous Metabolite
2,3-Diaminopropanoic acid hydrochloride is an endogenous metabolite known for its role as a biochemical building block and regulator in various metabolic pathways. It has been implicated in amino acid metabolism and can serve as a substrate in the synthesis of bioactive peptides. This compound is useful in research applications focusing on cellular metabolism, neurobiology, and the study of metabolic disorders. -
Endogenous Metabolite
11-Oxo etiocholanolone, also known as 11-Ketoetiocholanolone, is an endogenous metabolite that serves as a crucial marker for the detection of cortisol metabolites in feces and urine. This steroid plays a significant role in studies related to stress response and hormone metabolism. Its potential function as a pheromone further enhances its relevance in neuroendocrine research and behavioral studies. -
Endogenous Metabolite
Pteridine-2,4(1H,3H)-dione is an endogenous metabolite with a significant role in various biochemical pathways. This compound is involved in the regulation of cellular processes and may influence cellular responses to oxidative stress. Research applications include studies on metabolic pathways, enzyme activity, and the biological implications of pteridine derivatives in health and disease. -
Endogenous Metabolite
PNU-100440 is an endogenous metabolite of Linezolid, which primarily functions as an antibiotic targeting bacterial ribosomal protein synthesis. This compound is used in research to study the pharmacological profile of Linezolid and its metabolic pathway, providing insights into its therapeutic and side effects. The analysis of PNU-100440 can contribute to a better understanding of antibiotic metabolism and resistance in microbial organisms. -
Endogenous Metabolite
Hydroxy bosentan is an endogenous metabolite derived from Bosentan, primarily processed by the cytochrome P450 system in the liver. This compound retains 10%-20% of Bosentan's pharmacological activity, serving as a significant contributor to the overall therapeutic effects of the parent compound. Hydroxy bosentan is useful in research focused on metabolic pathways and the pharmacokinetics of endothelin receptor antagonists. -
Endogenous Metabolite
Cholesterol glucuronide is an endogenous metabolite that acts primarily through its role as a conjugate of cholesterol. It is produced in the liver by the enzyme UDP-glucuronosyltransferase and plays a significant role in cholesterol metabolism and transport. This compound is valuable for research applications focusing on lipid metabolism, cholesterol homeostasis, and related metabolic disorders. -
Endogenous Metabolite
Vitamin D3 octanoate, an octanoate ester of cholecalciferol, serves as an endogenous metabolite. It is known to induce cellular differentiation and inhibit the proliferation of cancer cells, making it a valuable compound for cancer research. This reagent is also applicable in studies focusing on vitamin D metabolism and its broader implications in cellular health. -
Endogenous Metabolite
3-(3-Hydroxyphenyl)propionic acid (3HPPA) functions as an endothelium-dependent promoter of nitric oxide (NO) release and an activator of endothelial nitric oxide synthase (eNOS). This compound facilitates vascular smooth muscle relaxation by enhancing NO synthesis in endothelial cells, leading to vasodilation and decreased peripheral vascular resistance. In studies, 3HPPA has shown a dose-dependent ability to lower systolic and diastolic blood pressure in spontaneously hypertensive rats without affecting cardiac contractility or heart rate. Its antihypertensive and vascular protective properties make it a valuable reagent for investigating cardiovascular disease prevention and treatment. -
Endogenous Metabolite
Hexokinase, Yeast is an enzyme that catalyzes the phosphorylation of glucose, playing a crucial role in the glycolytic pathway. This enzyme is vital for cellular energy production, contributing to the maintenance of mitochondrial integrity and promoting cell survival. It serves as an important reagent for studies focused on metabolic regulation and energy dynamics within yeast models. -
Endogenous Metabolite
NSC 16590 is an inhibitor of endogenous ethylene synthesis. This compound has been shown to effectively suppress the production of ethylene in cotyledonary segments of cocklebur, making it a valuable tool for studies on plant physiology and development. Its application in research can elucidate the roles of ethylene in growth processes and stress responses in plants. -
PPO Inhibitor
PPO-IN-10 is a selective inhibitor of protoporphyrinogen IX oxidase (PPO), functioning through its 2-phenylpyridine pyrrolidone scaffold. By inhibiting PPO, this compound induces the accumulation of photosensitive protoporphyrin IX, ultimately leading to necrosis in target weed leaves. PPO-IN-10 serves as a valuable tool in research aimed at the development of novel PPO herbicides. -
Stable Isotope
Saflufenacil-d7 is a deuterium-labeled variant of Saflufenacil, a herbicide belonging to the pyrimidinedione class. This compound acts as a potent inhibitor of protoporphyrinogen IX oxidase (PPO), providing effective preplant burndown and selective preemergence control of dicot weeds in various crops, including corn. Saflufenacil-d7 is primarily utilized in chemical research for tracking and understanding the behavior of Saflufenacil in biological systems and environmental studies. -
Protoporphyrinogen IX Inhibitor
PPO-IN-2 is a potent inhibitor of protoporphyrinogen IX oxidase, exhibiting a Ki value of 16 nM. This compound effectively disrupts heme biosynthesis by targeting the conversion of protoporphyrinogen IX to protoporphyrin IX. PPO-IN-2 is valuable for research into porphyrias and other disorders related to heme metabolism, providing insights into potential therapeutic strategies. -
PPO Inhibitor
PPO-IN-3 is a potent protoporphyrinogen oxidase (PPO) inhibitor, exhibiting a KI value of 0.67 nM. This compound demonstrates effective post-emergence herbicidal activity, making it valuable for agricultural applications aimed at weed control. Its specific mechanism of action provides a useful tool for research into herbicide efficacy and resistance mechanisms. -
Herbicide
Saflufenacil is a potent herbicide belonging to the pyrimidinedione chemical class that acts as a selective preemergence and preplant burndown agent for dicot weed control in various crops, including corn. Its primary mechanism involves the inhibition of protoporphyrinogen IX oxidase (PPO), leading to the disruption of chlorophyll synthesis and subsequent plant death. This compound is useful for researchers studying herbicide efficacy and weed management strategies in agricultural settings. -
Protoporphyrinogen Oxidase Inhibitor
Herbicidal agent 2 is a protoporphyrinogen oxidase (PPO) inhibitor that demonstrates effective herbicidal activity against a range of broadleaf and monocotyledon weeds. This compound serves as a valuable tool in agricultural research for studying herbicide resistance and developing new weed management strategies. Its targeted mechanism offers insights into the inhibition of crucial enzymatic pathways involved in plant growth and development. -
PPO Inhibitor
PPO-IN-7 is a potent inhibitor of protoporphyrinogen oxidase (PPO), a key enzyme involved in heme biosynthesis. This compound demonstrates significant herbicidal activity, making it valuable for research applications in plant biology and agricultural chemistry. Its ability to inhibit PPO provides insights into metabolic pathways and offers potential development avenues for herbicide formulations. -
PPO Inhibitor
PPO-IN-6 is a potent protoporphyrinogen oxidase (PPO) inhibitor that disrupts heme and chlorophyll biosynthesis. By inhibiting PPO activity, PPO-IN-6 can be utilized in cancer research and the investigation of other diseases linked to altered porphyrin metabolism. This compound serves as a valuable tool for studying the biochemical pathways involved in disease progression and therapeutic interventions. -
PPO Inhibitor
PPO-IN-15 is a potent inhibitor of protoporphyrinogen IX oxidase (PPO), targeting a key enzyme in the biosynthesis of chlorophyll. This compound demonstrates effective herbicidal activity against resistant weed species, making it a valuable tool in agricultural research. Its selectivity profiles indicate reduced phytotoxicity, particularly in wheat and rice, enhancing crop safety while managing weed populations. This functionality makes PPO-IN-15 suitable for studies aimed at developing sustainable weed management strategies. -
Pyruvate Kinase-R Activator
Tebapivat is a potent activator of pyruvate kinase-R (PKR), playing a critical role in enhancing glycolytic flux and energy metabolism. Its ability to stimulate PKR makes it valuable in research on metabolic disorders and cancer, where glycolysis is often dysregulated. Tebapivat can be utilized to investigate the effects of PKR activation on cellular energy production and related biochemical pathways. -
PKM2 Activator
PKM2 activator 2 is a potent activator of pyruvate kinase M2 (PKM2) with an AC50 value of 66 nM. This compound effectively enhances PKM2 activity, facilitating the restoration of normal glycolytic metabolism in various cellular models. It is valuable for research applications focusing on cancer metabolism and cellular energy regulation, offering insights into metabolic reprogramming in tumors. -
Pyruvate Kinase Activator
Etavopivat is a selective erythrocyte pyruvate kinase (PKR) activator that enhances glycolytic flux in red blood cells. It exhibits significant antisickling effects, making it a valuable tool for investigating sickle cell disease and other hemoglobinopathies. This compound is of interest in research aimed at improving red blood cell function and mitigating the complications associated with abnormal hemoglobin disorders. -
PKM2 Kinase Inhibitor
PKM2-IN-3 is a selective inhibitor of the PKM2 kinase, demonstrating an IC50 value of 4.1 μM. This compound exhibits notable anti-neuroinflammatory effects by disrupting PKM2-mediated glycolysis and inhibiting NLRP3 activation. PKM2-IN-3 is suitable for research applications focused on metabolic regulation and neuroinflammation pathways. -
GAPDH malonylation
Malonyl-NAC is a specific inhibitor of GAPDH malonylation that leads to decreased endogenous GAPDH activity in cells. This reagent enhances GAPDH malonylation and concurrently inhibits pyruvate kinase activity. It has been shown to limit metabolism and proliferation in highly glycolytic kidney cancer cell lines possessing tricarboxylic acid cycle mutations, making it a valuable tool for investigating metabolic alterations in cancer research. -
PKM2 Activator
PKM2 activator 5 is a selective activator of pyruvate kinase M2 (PKM2) with an AC50 value of 0.316 µM. This compound modulates the metabolic pathways of cancer cells by enhancing PKM2 activity, thereby promoting a shift from aerobic to anaerobic metabolism. PKM2 activator 5 has applications in cancer research, particularly in studies focused on metabolic reprogramming and the development of novel therapeutic strategies targeting cancer metabolism. -
PKM2 Inhibitor
CIAC001 is a potent inhibitor of Pyruvate Kinase M2 (PKM2), demonstrating noteworthy anti-neuroinflammatory properties. It effectively suppresses LPS-induced nitric oxide (NO) production in BV-2 microglial cells, with an IC50 of 2.5 μM, and exhibits protective effects against neuroinflammation in various mouse models. Additionally, CIAC001 has shown the potential to inhibit aspects of chronic morphine-induced addiction, making it a valuable reagent for research into neuroinflammatory processes and addiction pathways. -
PKM2 Inhibitor
NPD10084 is a potent inhibitor of pyruvate kinase M2 (PKM2) that targets non-glycolytic signaling in cancer cells. By disrupting the interaction between PKM2 and key regulatory proteins such as β-catenin and STAT3, NPD10084 effectively inhibits downstream signaling pathways. This compound exhibits significant antiproliferative activity against colorectal cancer cells, making it a valuable tool for cancer research and therapeutic investigations. -
MRSA Pyruvate Kinase Inhibitor
Deoxytopsentin is a marine bisindole alkaloid that functions as an inhibitor of pyruvate kinase in methicillin-resistant Staphylococcus aureus (MRSA). This compound demonstrates significant antibacterial activity against MRSA strains in vitro. Deoxytopsentin is derived from sponges and serves as a valuable research tool for studying bacterial metabolism and developing therapies targeting antibiotic-resistant infections. -
AADC/PKM2 Inhibitor
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase, primarily targeting the PKM2 enzyme. By binding directly to PKM2, Benserazide inhibits its activity, resulting in the suppression of aerobic glycolysis and the concurrent upregulation of oxidative phosphorylation (OXPHOS). This compound is valuable for research applications related to Parkinson's disease and melanoma. -
Pyruvate Kinase-R Activator
PKR Activator 1 is a potent activator of pyruvate kinase-R (PKR), facilitating enhanced glycolytic flux and promoting overall metabolic activity. This compound is instrumental in studies exploring metabolic disorders, cancer metabolism, and the regulation of cellular energy pathways. With its ability to modulate PKR activity, PKR Activator 1 serves as a valuable tool for researchers investigating the role of PKR in various biological contexts. -
PKM2 Activator
PF-06284674 is a potent activator of PKM2, a key enzyme involved in cancer metabolism. This compound enhances the activity of PKM2, promoting metabolic switching and cellular proliferation. It is primarily utilized in cancer research, particularly studies focused on targeting metabolic pathways for therapeutic intervention. -
Pyruvate Kinase Activator
ML202 is a potent allosteric activator of human pyruvate kinase M2 (hPK-M2), designed to enhance the enzyme's activity by modulating the cooperativity of phosphoenolpyruvate (PEP) binding. It specifically influences the PEP binding site with minimal impact on adenosine diphosphate (ADP) binding. This compound is valuable for studying metabolic pathways and cellular energy regulation, making it a useful tool in cancer research and metabolic studies.
