Fig. 1 · Structure
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TRC210258
Cat. No.
A72407
CAS
1431553-15-9
Endogenous Metabolite
TRC210258 is a potent TGR5 agonist that plays a critical role in modulating glucose and lipid metabolism. This compound enhances energy expenditure by promoting the secretion of glucagon-like peptide-1, leading to improved control of hyperglycemia and dyslipidemia in models of diet-induced obesity. Additionally, TRC210258 has demonstrated the ability to reduce plasma triglycerides and low-density lipoprotein cholesterol levels, thereby positively influencing lipid-related cardiovascular risk factors such as remnant cholesterol and triglyceride clearance. Its application in metabolic research highlights its potential for therapeutic intervention in metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1431553-15-9 |
| Applications | Endogenous Metabolite |
| Formula | C20H14ClFN4O2 |
| Molecular Weight | 396.80 |
| SMILES | O=C(N(C)C1=CC=C(C=C1)Cl)C2=C(N=C3N=CC=CN32)OC4=CC=C(C=C4)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.