Catalog No.
Product Name
Application
Product Information
Citations
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SCD Inhibitor
Elemicin is a potent inhibitor of Stearoyl-CoA Desaturase 1 (SCD1), acting through metabolic activation. This compound exhibits a range of biological activities, including anti-influenza, antimicrobial, antioxidant, and antiviral effects. Its mechanism and diverse applications make Elemicin a valuable reagent for research in metabolic studies and infectious disease treatment. Caution is advised, as Elemicin and its reactive metabolite, 1′-Hydroxyelemicin, may induce hepatotoxicity. -
Antibacterial Agent
1-Hydroxyphenazine is an antibacterial agent that targets α-Amylase with an IC50 value of 3.1 μg/mL. This compound demonstrates significant anticancer and anti-inflammatory activities, effectively reducing proliferation in A549, 1321N1, and RAW264.7 cell lines. Additionally, 1-Hydroxyphenazine exhibits notable antifungal and antibacterial properties against pathogens such as Candida albicans, Aspergillus fumigatus, Escherichia coli, and Xanthomonas campestris, making it a valuable reagent for various biological research applications. -
Endogenous Metabolite
Dimethyl sulfone, also known as methyl sulfonyl methane, is an endogenous metabolite derived from the metabolism of methanethiol and intestinal bacteria. This compound exhibits the ability to inhibit choriocapillary endothelial cell proliferation while also demonstrating various biological activities, including anti-inflammatory, antioxidant, and local anesthetic properties. Its diverse effects suggest potential applications in neuroprotection and other therapeutic areas. -
Antimicrobial Agent
Methyl caffeate is an antimicrobial agent primarily known for its moderate antimicrobial and significant antimycobacterial activities. It also demonstrates α-glucosidase inhibition, oxidative stress reduction, and anti-platelet effects. Additionally, methyl caffeate exhibits antiproliferative properties in cervical adenocarcinoma and anticancer effects across lung and leukemia cell lines, making it a valuable reagent for various biochemical and pharmacological studies. -
Herbicide
Diclosulam is a selective herbicide that acts by inhibiting the enzyme acetolactate synthase, essential for amino acid synthesis in plants. It demonstrates a Ki value of less than 32 nM, showcasing its potent activity. The compound exhibits minimum inhibitory concentrations (MIC) and MIC50 values of 6.25 μM and 1.40 μM against CBS10913, and 12.5 μM and 3.01 μM against CBS12373 strains, respectively. Diclosulam is utilized in agricultural research for effective weed management solutions. -
Sex pheromones
3-Pentanol is an organic compound recognized for its role as a component of sex pheromones released by various insects. This compound has been shown to enhance plant immunity against microbial pathogens and pests by activating salicylic acid (SA) and jasmonic acid (JA) signaling pathways. Its utilization in agricultural research may provide insights into pest management and crop protection strategies. -
Drug Metabolite
Rabeprazole Sulfide is a sulfide metabolite of the proton pump inhibitor Rabeprazole. It exhibits inhibitory effects on the motility of Helicobacter pylori, making it a valuable tool for studying this bacterial infection. Research utilizing Rabeprazole Sulfide can contribute to a better understanding of Helicobacter pylori's role in gastrointestinal diseases. -
TrxR1 Inhibitor
Evernic Acid is a potent inhibitor of thioredoxin reductase 1 (TrxR1), demonstrating significant antiproliferative effects on human breast cancer cells. It disrupts the NF-κB signaling pathway by preventing p65 nuclear translocation and IκBα phosphorylation, which subsequently reduces inflammatory mediators. In addition to its role as an antioxidant and neuroprotective agent, Evernic Acid protects neurons from oxidative stress and mitochondrial dysfunction. Furthermore, it inhibits key enoyl reductases in Plasmodium falciparum and downregulates quorum sensing and biofilm formation in Pseudomonas aeruginosa, showcasing its antibacterial and antifungal properties. This compound is valuable for research focused on breast cancer, neurodegenerative diseases, and microbial infections. -
DHFR Inhibitor
Aditoprime is a selective inhibitor of bacterial dihydrofolate reductase (DHFR), demonstrating IC50 values of 47 nM and 520 nM for E. coli and L. casei DHFR, respectively. By inhibiting the conversion of dihydrofolic acid to tetrahydrofolic acid, Aditoprime effectively impairs bacterial folate synthesis. This compound exhibits broad-spectrum antibacterial activity and possesses favorable pharmacokinetic properties, making it a useful reagent in microbiological research and antibiotic development studies. -
Mating Pheromone-encoding Peptide
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candida albicans, primarily targeting the mating type locus MTLa. This compound induces cell growth arrest in Candida albicans, making it a valuable tool for investigating the mechanisms of mating and biological signaling in this organism. Additionally, SP1 is applicable in research focused on the prevention and treatment of Candida albicans infections. -
Precursor Form
Oseltamivir acid methyl ester hydrochloride is a precursor to the neuraminidase inhibitor oseltamivir acid, which exhibits antiviral activity against influenza viruses. Upon administration, it is metabolized by carboxylesterase 1 (CES1) to yield oseltamivir acid, facilitating its therapeutic effects. This reagent is primarily utilized in research applications focused on antiviral drug development and metabolic studies involving oseltamivir. -
MAO-A/B Inhibitor
Tedizolid phosphate sodium is a selective inhibitor of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). This compound exhibits significant activity against Gram-positive bacteria, making it valuable in the study of antimicrobial resistance and the development of new therapeutic agents. Its mechanisms of action and inhibition properties facilitate research into neurological disorders and other conditions associated with monoamine dysregulation. -
Endogenous Metabolite
Farnesol is a sesquiterpene alcohol that functions as an endogenous metabolite with notable antimicrobial properties. It has been shown to modulate cell-to-cell communication in Candida albicans and exhibits inhibitory activity against various bacterial species. This compound is valuable for research in microbial interactions and the modulation of pathogenic behaviors. -
α-glucosidase Inhibitor
1-Deoxynojirimycin hydrochloride is a potent α-glucosidase inhibitor, primarily utilized for modulating postprandial blood glucose levels. This compound demonstrates notable antihyperglycemic and anti-obesity effects, making it valuable in diabetes mellitus research. Additionally, 1-Deoxynojirimycin hydrochloride exhibits antiviral properties, contributing to its diverse applicability in metabolic and infectious disease studies. -
HMG-CoA Synthase Inhibitor
Hymeglusin is a fungal β-lactone antibiotic that functions as a potent inhibitor of HMG-CoA synthase, exhibiting an IC50 of 0.12 μM. This compound covalently modifies the active cysteine residue at position 129 of the enzyme, thereby disrupting its activity. Hymeglusin is primarily utilized in research applications focused on lipid metabolism and studying the modulation of cholesterol biosynthesis pathways. -
Phospholipase C Inhibitor, Angiogenesis Modulator
Neomycin is an aminoglycoside antibiotic known for its role as a phospholipase C (PLC) inhibitor and angiogenesis modulator. It effectively inhibits the nuclear translocation of angiogenin, resulting in reduced cell proliferation and angiogenesis. Additionally, Neomycin interferes with IP3-mediated calcium release and MgATP-dependent calcium uptake, influencing skeletal muscle calcium transients. Its ability to modulate crucial biological pathways makes Neomycin a valuable tool for cancer research and understanding microbial impact on health. Prolonged exposure may lead to adverse effects such as hearing impairment and kidney damage. -
Cephalosporin Antibiotic
Cefetecol is a broad-spectrum cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. In addition to its antibacterial properties, Cefetecol also acts as an α-glucosidase inhibitor, demonstrating in vivo anti-diabetic activity in diabetic mouse models. This compound is suitable for research applications in both antibacterial and anti-diabetic studies. -
Endogenous Metabolite
Defensin HNP-2 human is an endogenous antibiotic peptide that acts as a monocyte chemotactic factor, produced primarily by human neutrophils. This peptide plays a pivotal role in the innate immune response by exerting antimicrobial activity and recruiting immune cells to sites of infection. It is widely used in research related to immunology and host defense mechanisms, providing insights into innate immune responses and potential therapeutic applications for infectious diseases. -
Herbicide
N-Acetyldemethylphosphinothricin tripeptide is a prodrug herbicide targeting amino acid biosynthesis in plants. Comprising the unique amino acid phosphinothricin and two alanine residues, this compound exhibits significant herbicidal activity by inhibiting the biosynthetic pathway of glutamine and glutamate. Its ability to penetrate bacterial cells via peptide uptake systems enhances its efficacy, making it a valuable tool in agricultural research and development related to herbicide mechanisms and plant growth regulation. -
Fungal Metabolite
Viridicatin is a fungal metabolite derived from Penicillium species. This compound exhibits moderate in vitro antibiotic activity, specifically targeting Mycobacterium tuberculosis. Viridicatin can be utilized in research studies focused on tuberculosis treatment and the exploration of antifungal mechanisms, providing valuable insights into microbial interactions and resistance patterns. -
Precursor Form
Oseltamivir acid methyl ester is a precursor of the neuraminidase inhibitor and antiviral agent oseltamivir acid. It is converted into oseltamivir acid by the enzyme carboxylesterase 1 (CES1). This compound is useful in research applications focused on antiviral therapeutic development and the mechanistic understanding of flu virus inhibition. -
Antibacterial/PAI-1 Inhibitor
Geodin is a fungal metabolite that acts as an antibacterial agent. It also functions as a potent inhibitor of plasminogen activator inhibitor-1 (PAI-1), making it a valuable tool for studying the regulation of fibrinolysis and related pathways. This compound is used in various research applications to explore its effects on bacterial growth and PAI-1 mediated processes. -
Tosufloxacin Derivative
A-71497 is a tosufloxacin derivative that serves as a prodrug, generating elevated plasma levels of tosufloxacin following both oral and subcutaneous administration in murine models. This compound is primarily utilized in antibiotic research to explore its pharmacokinetics and therapeutic efficacy. Its ability to enhance bioavailability makes it a valuable tool for studying antibiotic treatment strategies in preclinical settings. -
Herbicide/Antimicrobial Precursor
Bialaphos sodium is a potent phosphinothricinylalanylalanine that serves as a precursor for herbicides and antimicrobial agents. Upon uptake by bacterial or plant cells, it is metabolized into phosphinothricin, which effectively inhibits glutamine synthetase activity. This compound is valuable for research in herbicidal mechanisms and antimicrobial studies. -
Endogenous Metabolite
Roemerine is an alkaloid derived from the leaves of Fibraurea recisa Pierre, acting primarily as an endogenous metabolite. It demonstrates antibacterial, anticancer, and antidepressant activities, with mechanisms including reversal of multidrug resistance in cultured cells and modulation of the cAMP signaling pathway. Additionally, Roemerine enhances neuronal activity by increasing brain-derived neurotrophic factor (BDNF) protein expression and influencing serotonergic and glutamatergic systems. This compound is valuable for research applications in cancer, infectious diseases, and neurological disorders. -
MAO-A/5-HT2AR Inhibitor
MAO-A/5-HT2AR-IN-1 is a potent dual inhibitor of monoamine oxidase A (MAO-A) and serotonin receptor 2A (5-HT2AR), exhibiting IC50 values of 0.004 μM and 0.014 μM, respectively. This compound demonstrates significant potential in the field of antidepressant research, contributing to the modulation of serotonin levels and receptor activity. It is a valuable tool for investigating the pharmacological impact of MAO-A and 5-HT2AR inhibition in neuropsychiatric disorders. -
PCSK9 ATTEC
PCSK9 autophagic degrader 2 (W6) targets proprotein convertase subtilisin/kexin type 9 (PCSK9) through an autophagic mechanism, displaying a DC50 value of 20.6 nM. This compound exhibits significant antiatherosclerotic activity, with a dissociation constant (KD) for LC3B of 2.5 μM. PCSK9 autophagic degrader 2 (W6) facilitates research into cholesterol homeostasis, cardiovascular disease, and potential therapeutic interventions targeting the PCSK9 pathway. -
PKMζ Inhibitor
ZIP is a selective peptide inhibitor of Protein Kinase M zeta (PKMζ), which plays a crucial role in synaptic plasticity and memory processes. This compound effectively impairs morphine-induced conditioned place preference, making it a valuable tool for studying addiction and the molecular mechanisms underlying memory formation. Research applications include investigating the role of PKMζ in memory reinforcement and the modulation of synaptic strength. -
FXR Agonist
FXR agonist 17 functions as a steroidal agonist of the farnesoid X receptor (FXR), exhibiting EC50 values of 42.2 nM in TR-FRET assays and 176.4 nM in luciferase reporter assays. This compound also activates TGR5 with an EC50 of 2.6 μM while showing no activation of hMRGPRX4. FXR agonist 17 demonstrates significant biological activity through its anti-inflammatory, hepatoprotective, and antifibrotic properties, contributing to the reduction of non-alcoholic steatohepatitis (NAFLD) activity scores and alleviating liver fibrosis severity. It serves as a valuable tool for research into NAFLD, cholestatic liver disease, and liver fibrosis. -
DHFR Inhibitor
Tetroxoprim is a potent dihydrofolate reductase (DHFR) inhibitor with significant antimicrobial properties. It serves as a critical tool in the study of antimicrobial resistance and the development of new therapeutic agents. Its ability to inhibit folate synthesis makes it valuable for research in infectious disease and related biochemical pathways. -
DHFR Inhibitor
Fanotaprim is a selective inhibitor of dihydrofolate reductase (DHFR), demonstrating IC50 values of 1.57 nM for Toxoplasma gondii DHFR and 308 nM for human DHFR. This compound is particularly relevant for investigating toxoplasmosis, providing insight into potential therapeutic strategies against this parasitic infection. Its targeted inhibition of tgDHFR makes Fanotaprim a valuable tool for research in pharmacology and microbiology. -
Folic Acid/DHFR Antagonist
Aminopterin sodium is a folic acid antagonist that primarily targets dihydrofolate reductase (DHFR). By inhibiting DHFR, it disrupts folate metabolism, leading to decreased nucleic acid synthesis. This compound is primarily utilized in the treatment of acute lymphoblastic leukemia and various cancers. Additionally, Aminopterin sodium is employed as an immunosuppressant for the management of autoimmune disorders. -
DHFR Inhibitor
Lysine-methotrexate is a dihydrofolate reductase (DHFR) inhibitor, structurally related to Methotrexate. This compound exhibits potent biological activity by inhibiting folate metabolism, making it useful in studying cellular processes that rely on nucleotide synthesis. Lysine-methotrexate is applicable in cancer research and other therapeutic contexts where modulation of DHFR activity is of interest. -
MtDHFR Inhibitor
DHFR-IN-2 is a potent uncompetitive inhibitor of MtDHFR (dihydrofolate reductase from Mycobacterium tuberculosis), demonstrating an IC50 value of 7 μM. This compound serves as a valuable tool for tuberculosis research, aiding in the study of pathogenic processes and potential therapeutic strategies against TB. -
DHFR Inhibitor
Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an established antifolate agent. This compound functions as an antimetabolite, exhibiting cytotoxic effects on rapidly dividing cells, making it relevant for cancer research. Its ability to inhibit DHFR provides a valuable tool for investigating folate metabolism and developing therapeutic strategies against various malignancies. -
DHFR Inhibitor
TNP-351 is a dihydrofolate reductase (DHFR) inhibitor known for its potent antitumor activity. This antifolate compound exhibits efficacy against both leukemia and solid tumor cells in vitro and in vivo, making it a valuable tool in cancer research. Its mechanism of action involves the disruption of folate metabolism, ultimately hindering DNA synthesis and cell proliferation. -
SCDKI Pathway Inhibitor
SNX7 is a selective inhibitor of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. This compound plays a crucial role in studying cellular senescence and various CDKI-related diseases. By targeting the CDKI pathway, SNX7 serves as a valuable tool in cancer research and other conditions where cell cycle regulation is disrupted. -
Alkyltriazine Herbicide
Indaziflam is an alkyltriazine herbicide that acts by targeting the cellulose synthase complex, leading to the inhibition of cellulose biosynthesis in plant cell walls. This compound induces notable physiological alterations in plants, including radial swelling, ectopic lignification, and abnormal root and cell morphology, as well as reduced root and hypocotyl elongation. Additionally, Indaziflam has been shown to cause DNA strand breaks and micronucleus formation in HepG2 cells, making it a valuable reagent for research on monocot weed control and understanding herbicide mechanisms. -
Cathepsin L Inhibitor
Gallinamide A is a potent inhibitor of cathepsin L, demonstrating an IC50 value of 17.6 pM. This compound plays a crucial role in research applications focused on investigating the functions of cathepsin L in various biological processes, including protein degradation and immune response regulation. Its inhibitory activity makes Gallinamide A a valuable tool for studying the implications of cathepsin L in pathophysiological conditions. -
RAR Agonist
MDI-403 is a highly potent retinoic acid receptor (RAR) agonist, exhibiting an EC50 value of less than 1 μM. It demonstrates significant antiviral activity against SARS-CoV-2 by dose-dependently inhibiting the expression of viral nucleoprotein (NP) and decreasing the proportion of infected cells, mainly during the virus invasion stage. MDI-403 serves as a valuable tool for research focused on the mechanisms of antiviral activity and potential therapies against SARS-CoV-2. -
α-Glucosidase Inhibitor
DNJ-20 is an α-glucosidase inhibitor with an IC50 of 55.3 μg/mL, demonstrating significant broad-spectrum activity against SARS-CoV-2. It disrupts the endoplasmic reticulum-associated glycoprotein folding process, inhibiting proper processing of viral glycoproteins and consequently blocking viral particle formation and infection. DNJ-20 exhibits IC50 values as low as 1.49 μM against various SARS-CoV-2 variants, as well as HCoV-229E and HCoV-OC43. This inhibitor is suited for pan-coronavirus research applications. -
CYP2C1/CYP2C19 Inhibitor
CYP2C1/CYP2C19-IN-2 is a potent inhibitor of the CYP2C1 and CYP2C19 enzymes. This compound exhibits minimal hepatotoxicity and lacks Ames toxicity, making it a safer choice for research applications. CYP2C1/CYP2C19-IN-2 is particularly useful in studies investigating antiviral mechanisms against Zika virus (ZIKV). -
CYP2C9/CYP2C19 Inhibitor
CYP2C9/CYP2C19-IN-1 is a potent inhibitor of the cytochrome P450 enzymes CYP2C9 and CYP2C19. This compound exhibits key biological activity by effectively modulating drug metabolism pathways without hepatotoxic effects or Ames toxicity. It serves as a valuable tool for research applications, including studies on anti-Zika virus (ZIKV) therapeutics. -
PDE4B/D Inhibitor
PDE4B/D-IN-5 is a potent inhibitor of phosphodiesterase 4B and 4D, displaying IC50 values of 3.4 nM and 2.2 nM, respectively, with limited central nervous system penetration. This compound effectively inhibits TNF-α production and demonstrates significant anti-inflammatory, antioxidant, and anti-apoptotic properties by reducing the Bax/Bcl2 ratio and mitigating oxidative stress through decreased myeloperoxidase activity and nitric oxide levels. PDE4B/D-IN-5 is suitable for research applications in acute lung injury and related inflammatory conditions. -
Endogenous Metabolite
Hexadecanedioic acid, also known as Thapsic acid, is an endogenous metabolite that plays a crucial role in cellular metabolism. It inhibits IRE1α-mediated XBP1 splicing, thereby affecting flipogenesis and ferroptosis. Additionally, Hexadecanedioic acid downregulates the expression of XBP1 and Hrd1 while activating the Nrf2/SLC7A11/GPX4 pathway. This compound is valuable for research into metabolic-associated fatty liver disease and related metabolic disorders. -
MAO-B Inhibitor
Monoamine Oxidase B Inhibitor 6 is a highly selective, reversible, and competitive inhibitor of monoamine oxidase B (MAO-B) with a significant brain-blood barrier penetration capability, exhibiting an IC50 of 0.11 μM. This compound demonstrates notable antioxidant and neuroprotective properties and is applicable in the study of neurodegenerative diseases. Researchers investigating the role of MAO-B in neurobiology may find it a valuable tool for elucidating mechanisms of disease and exploring therapeutic avenues. -
CYP3A Inhibitor
ALT-2074 is a CYP3A inhibitor with an IC50 value ranging from 2.0 to 2.6 μM, functioning as a catalytic analogue of glutathione peroxidase. Although it demonstrates a weak inhibitory effect on CYP3A in vivo, it serves as a valuable tool for studying the role of oxidative stress in inflammatory diseases, including acute coronary syndrome. This compound is particularly useful in research investigating the interplay between reactive oxygen species and metabolic pathways. -
ALDH1A Inhibitor
ALDH1A Inhibitor 673A is a selective inhibitor targeting ALDH1A1, ALDH1A2, and ALDH1A3, with IC50 values of 246 nM, 230 nM, and 348 nM, respectively. This compound demonstrates minimal inhibitory effects on other ALDH family members. It has been shown to induce necroptotic death in ovarian cancer stem-like cells and cause DNA double strand breaks in cancer cells. ALDH1A Inhibitor 673A serves as a valuable tool for researching ovarian cancer mechanisms and treatment strategies. -
Necroptosis/11β-HSD1 Inhibitor
Necroptosis-IN-3 is a selective inhibitor of necroptosis, primarily targeting TNF-α induced necroptotic pathways. Additionally, this compound inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby modulating glucocorticoid metabolism. Its key biological activities make it a valuable tool for researchers studying necroptosis and related cellular mechanisms in various disease models. -
Herbicide/Microtubule inhibitor
Ethalfluralin is a dinitroaniline herbicide that functions as a microtubule inhibitor. By disrupting intranuclear spindle formation, Ethalfluralin effectively obstructs nuclear division and cytokinesis in parasites. This compound also enhances phosphorylation of NF-κB and P38 MAPK while inhibiting the PI3K/AKT signaling pathway, leading to impaired mitochondrial functionality, apoptosis, endoplasmic reticulum stress, autophagy, and increased reactive oxygen species (ROS) production. Ethalfluralin is particularly relevant for research applications in toxoplasmosis and related parasitic diseases.
