ALDH3A1-IN-4 is a selective inhibitor of ALDH3A1, exhibiting an IC50 of 0.2 μM. This compound interacts with the aldehyde-binding pocket of ALDH3A1 through hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 functions as a chemosensitizer, enhancing the antiproliferative effects of mafosfamide in ALDH3A1-expressing cancer cells while sparing non-cancer cells. It is particularly relevant for research on lung adenocarcinoma and glioblastoma.
ALDH3A1-IN-4 is a selective inhibitor of ALDH3A1, exhibiting an IC50 of 0.2 μM. This compound interacts with the aldehyde-binding pocket of ALDH3A1 through hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 functions as a chemosensitizer, enhancing the antiproliferative effects of mafosfamide in ALDH3A1-expressing cancer cells while sparing non-cancer cells. It is particularly relevant for research on lung adenocarcinoma and glioblastoma.
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