Catalog No.
Product Name
Application
Product Information
Citations
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IDHP Isomer
(R)-IDHP is an isomer of isovaleryl-DL-3-hydroxybutyric acid, functioning primarily by inhibiting Ca2+ release and modulating Ca2+ inward flow in both voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. This compound exhibits vasorelaxant properties and is valuable in research focused on cardiovascular disease mechanisms and treatments. Its biological activity makes it a useful tool for investigating vascular dynamics and related pathophysiological conditions. -
5-lipoxygenase Inhibitor
ETH-615 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which play a significant role in inflammatory processes. This compound demonstrates key biological activity in reducing inflammation and may have implications for research into cardiovascular diseases and other inflammatory disorders. Its efficacy in modulating leukotriene synthesis makes ETH-615 valuable for studies aimed at understanding the underlying mechanisms of cardiovascular pathology. -
15-LOX-1 Inhibitor
ML351 is a potent inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 200 nM, demonstrating exceptional selectivity with over 250-fold preference compared to related isozymes such as 5-LOX, platelet 12-LOX, and 15-LOX-2, as well as ovine COX-1 and human COX-2. This compound has shown significant biological activity in preventing dysglycemia and reducing β-cell oxidative stress in a nonobese diabetic mouse model of Type 1 Diabetes. ML351 is useful in studying the role of 15-LOX-1 in metabolic diseases and may have implications for therapeutic strategies targeting oxidative stress in diabetes. -
Lipoxygenase Inhibitor
Masoprocol, a lipoxygenase inhibitor, demonstrates significant antihyperglycemic activity by effectively lowering glucose levels and hepatic triglycerides in vivo. This compound is particularly valuable for researching type II diabetes mechanisms and potential therapeutic strategies. Its ability to modulate metabolic pathways positions Masoprocol as an important reagent in diabetes research. -
15-LOX-1 Inhibitor
15-LOX-1 inhibitor 1 is a selective inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. This compound demonstrates protective effects on macrophages against cytotoxicity induced by lipopolysaccharide, while also inhibiting nitric oxide formation and lipid peroxidation. With its ability to modulate inflammatory pathways, 15-LOX-1 inhibitor 1 is valuable for research applications focused on inflammation and oxidative stress. -
5-Lipoxygenase Inhibitor
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is a polyunsaturated fatty acid that acts as a potent inhibitor of 5-lipoxygenase, thereby reducing the synthesis of leukotrienes and 5-HETE. This compound has been shown to enhance the levels of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid is employed in research focusing on metabolic diseases and inflammatory pathways, making it a valuable tool for studying lipid metabolism and related disorders. -
5/12/15-Lipoxygenase Inhibitor
2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase, demonstrating IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively. This compound is valuable in the study of lipoxygenase pathways and their role in inflammatory processes. 2-TEDC is particularly relevant for research focused on atherosclerosis, providing insights into its mechanistic actions and potential therapeutic interventions. -
15-LOX-1 Inhibitor
ThioLox is a competitive inhibitor of 15-lipoxygenase-1 (15-LOX-1) with a Ki value of 3.30 μM. This compound exhibits significant anti-inflammatory and neuroprotective effects, making it a valuable tool in research focused on inflammation-related disorders and neurodegenerative diseases. Its ability to modulate 15-LOX-1 activity facilitates the exploration of lipid metabolism and its impact on cellular health. -
12/15-Lipoxygenases Inhibitor
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is an effective inhibitor of 12/15-Lipoxygenases (LO). This compound demonstrates significant anti-inflammatory properties, making it a valuable tool for investigating the role of lipoxygenases in various diseases, including type 1 diabetes mellitus. Its specificity towards these enzymes provides researchers with a robust agent for studying inflammatory pathways and potential therapeutic interventions. -
5-LOX Inhibitor
5-LOX-IN-2 is a selective inhibitor of 5-lipoxygenase (5-LOX), exhibiting an IC50 value of 0.33 μM. This compound effectively inhibits 5-LOX activity in a dose-dependent manner and has demonstrated the ability to reduce cell viability in renal cancer cells while promoting apoptosis. Its potential applications in cancer research make it a valuable tool for studying the role of 5-LOX in tumor biology. -
Tyrosinase/LOX Inhibitor
3-Hydroxycoumarin is a potent inhibitor of tyrosinase and lipoxygenase, exhibiting an IC50 of 26 μM against recombinant human tyrosinase and a Ki of 3.39 μM. It also demonstrates effective inhibition of lipoxygenase with an IC50 of 9.5 μM. Additionally, 3-Hydroxycoumarin displays significant DPPH free radical scavenging activity (IC50 = 31.2 μM) and offers photoprotective benefits for sea urchin zygotes and embryos, making it a valuable reagent for research in enzymatic inhibition and oxidative stress studies. -
Lipoxygenase Inhibitor
5,8,11-Eicosatriynoic acid is a potent lipoxygenase inhibitor that effectively disrupts the biosynthesis of leukotriene C4 (LTC4) in mast cell tumor cells. This compound is useful for researchers investigating the role of leukotrienes in inflammation and allergic responses. Additionally, it can be employed in studies focused on the modulation of lipoxygenase pathways in various biological systems. -
5-LOX Inhibitor
Picrinine, a 5-lipoxygenase (5-LOX) inhibitor, is an alkaloid derived from the leaves of Alstonia scholaris. This compound demonstrates significant anti-inflammatory effects by targeting and inhibiting the activity of the 5-LOX enzyme. Picrinine is useful for research applications related to inflammation and may provide insights into therapeutic strategies for inflammatory diseases. -
Lipoxygenase Inhibitor
Lonapalene is a selective inhibitor of 5-lipoxygenase (5-LO). It exhibits significant anti-inflammatory activity by blocking the production of leukotrienes, which are mediators involved in various inflammatory conditions. This compound is primarily utilized in research aimed at understanding and exploring therapeutic interventions for diseases associated with leukotriene signaling. -
LOX-2 Inhibitor
MLS000545091 is a potent and selective inhibitor of lipoxygenase-2 (LOX-2), demonstrating an IC50 value of 2.6 μM for the human enzyme h15-LOX-2. This compound is valuable for research into inflammatory processes and related diseases, facilitating investigations into the role of LOX-2 in various biological pathways. Its specificity makes it a useful tool for exploring therapeutic strategies targeting LOX-2-related conditions. -
5-Lipoxygenase Inhibitor
5-LOX-IN-4 is a selective inhibitor of 5-Lipoxygenase (5-LOX), a key enzyme involved in the biosynthesis of leukotrienes. This compound plays a significant role in modulating inflammatory responses and is valuable for research applications targeting asthma, allergies, and other inflammatory diseases. Its inhibition of 5-LOX may contribute to understanding leukotriene-related pathways and exploring potential therapeutic strategies. -
Lipoxygenase Inhibitor
Setileuton is a selective inhibitor of 5-lipoxygenase, effectively modulating the oxidation of arachidonic acid. It demonstrates significant inhibition of leukotriene B4 (LTB4) production in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. This compound is valuable for research applications focused on inflammatory pathways and leukotriene-mediated processes. -
LOX-1 Inhibitor
KKII5 is a selective inhibitor of Lipoxygenase-1 (LOX-1) with an IC50 value of 19 μM. It effectively reduces lipid peroxidation, an important process associated with oxidative stress and inflammation. This compound is suitable for research applications involving the modulation of lipoxygenase activity and the investigation of related pathophysiological conditions. -
12-LOX Inhibitor
NCTT-956 is a selective inhibitor of 12-lipoxygenase (12-LOX), primarily targeting its enzymatic activity. This compound demonstrates potent inhibition of 12-LOX, which plays a critical role in various inflammatory processes and platelet function. NCTT-956 is valuable for research applications exploring the mechanisms of lipid-mediated signaling and the development of therapeutic strategies for inflammation-related diseases. -
Lipoxygenase
13(S)-Hydroxy-9,11,13-octadecatrienoic acid (13(S)-HPOTrE(γ) is an endogenously formed monohydroxy polyunsaturated fatty acid that serves as a substrate for soybean lipoxygenase-1 (LO-1) involved in the metabolism of γ-linolenic acid. It exhibits inhibitory effects on soybean LO-1 activity at concentrations exceeding 100 μM, and is also a precursor for the synthesis of all four isomers of 6,13-DiHOTrE. This compound is valuable for research focusing on lipoxygenase activity and the biochemical pathways involving PUFA metabolism. -
5-LOX Inhibitor
1-Naphthyl 3,5-dinitrobenzoate is a selective inhibitor of 5-lipoxygenase (5-LOX), demonstrating potent activity with an IC50 of 1.04 µM for 5-LOX and 3.6 µM for mPGES-1. This compound exhibits strong anti-inflammatory properties, evidenced by its IC50 value of 8.6 μM in human whole blood assays. It is a valuable tool for investigating the mechanisms of inflammation and exploring therapeutic strategies targeting leukotriene synthesis. -
Lipoxygenase Inhibitor
(-)-Dihydroguaiaretic acid is a potent lipoxygenase inhibitor that exhibits significant antioxidant properties. It effectively inhibits the oxidation of unsaturated fatty acids and scavenges free radicals, contributing to its protective effects. Additionally, this compound demonstrates anticancer activity with an IC50 value of 7.49 μM in A549 human lung adenocarcinoma cells, making it a valuable tool for cancer research and oxidative stress studies. -
Lipoxygenase Inhibitor
15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis. -
Lipoxygenase Inhibitor
Ro 3-1314 is a potent lipoxygenase inhibitor, specifically targeting the metabolism of linoleic acid. This compound demonstrates significant biological activity by stimulating antigen-induced contraction in guinea-pig tracheal spirals and promoting the immunological release of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea-pig lung fragments. Ro 3-1314 is valuable for research applications focused on inflammation and respiratory responses. -
Arachidonic Acid 5-Lipoxygenase Inhibitor
BW B70C is a potent and selective inhibitor of arachidonic acid 5-lipoxygenase, demonstrating oral bioactivity. It effectively inhibits both acute and allergic bronchoconstriction, as well as late-phase eosinophil accumulation following allergen exposure in guinea pigs. BW B70C prevents the synthesis of leukotriene C4 and modulates leukocyte migration to the airway lumen, along with reducing albumin microvascular leakage. This compound holds promise for research into anti-asthmatic agents and related inflammatory conditions. -
5-LOX Inhibitor
5-LOX-IN-1 is a potent inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. This compound is essential for studying inflammatory pathways and the role of 5-LOX in various inflammatory diseases. Its inhibition of 5-LOX provides a valuable tool for research into therapeutic strategies targeting inflammation. -
Lipoxygenase Inhibitor
3-Chloroiminodibenzyl is a potent dual inhibitor of secreted human lipoxygenase (sHE) and 5-lipoxygenase (5-LOX). It exhibits inhibitory activity with IC50 values of 140 μM and 6.5 μM, respectively. This compound is utilized in research applications focusing on lipid signaling and inflammation pathways, making it valuable for studies related to inflammatory diseases and related therapeutic developments. -
Lipoxygenase Inhibitor
(±)15-HEDE is a racemic mixture comprised of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE, derived from eicosadienoic acid within macrophages. This compound acts as a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 35 μM. 15-HEDE is utilized in research to investigate lipoxygenase pathways and their implications in inflammatory processes. Its inhibitory effects on 5-LO make it a valuable tool for studying the modulation of leukotriene biosynthesis and related biological activities. -
5-Lipoxygenase Inhibitor
ZD 2138 is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes, which play a significant role in inflammation and bronchoconstriction. This compound has demonstrated potential in alleviating aspirin-induced bronchoconstriction, making it a valuable tool in asthma research and studies focused on respiratory disorders. Its application in modulating inflammatory pathways positions ZD 2138 as an important reagent for investigating therapeutic strategies in related pulmonary conditions. -
Lipoxygenase Inhibitor
Enazadrem is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the inflammatory response. It exhibits significant anti-inflammatory activity, making it a valuable tool for research in fields such as immunology and cancer therapy. This compound aids in the elucidation of pathways related to leukotriene synthesis and may contribute to the development of therapeutic strategies targeting inflammation-related diseases. -
5-Lipoxygenase Inhibitor
TA-270 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which are key mediators in inflammatory processes. This quinolinone derivative is primarily utilized in asthma research to elucidate the role of leukotrienes in airway inflammation and hyperreactivity. Its selective inhibition of 5-lipoxygenase provides a valuable tool for investigating therapeutic strategies aimed at respiratory conditions. -
5-lipoxygenase inhibitor
HZ52 is a reversible inhibitor of 5-lipoxygenase, effectively blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes. This compound is valuable for research applications aimed at understanding inflammatory responses and the role of leukotrienes in various diseases. HZ52 may be useful in exploring therapeutic strategies for conditions such as asthma, arthritis, and other inflammatory disorders. -
5-Lipoxygenase Inhibitor
AHR-5333 is a selective inhibitor of 5-lipoxygenase, primarily targeting human blood neutrophils. This compound demonstrates significant and prolonged activity in in vivo models of immediate hypersensitivity, specifically in rats and guinea pigs. AHR-5333 is applicable in research related to inflammatory responses and may provide insights into therapeutic strategies for conditions associated with leukotriene overproduction. -
5-Lipoxygenase Inhibitor
5-LOX-IN-3 is a potent inhibitor of 5-Lipoxygenase, exhibiting an IC50 of less than 1 μM. This compound is valuable for research focused on inflammatory diseases, cancer, stroke, and Alzheimer’s disease, allowing for the exploration of its therapeutic potential in modulating inflammatory pathways. 5-LOX-IN-3 serves as a useful tool in the study of these critical health conditions. -
5-LOX Inhibitor
Tagorizine is a potent inhibitor of 5-lipoxygenase (5-LOX), a key enzyme in the leukotriene biosynthesis pathway. This reagent is valuable for studying vascular biology, particularly in examining cerebral and peripheral blood vessel dilation. Its inhibitory properties make it useful for research into inflammatory responses and related vascular conditions. -
5-LOX Inhibitor
5,6-Dehydroarachidonic acid is an inhibitor of 5-lipoxygenase (5-LOX), targeting the enzymatic pathway responsible for leukotriene biosynthesis. This compound effectively reduces leukotriene production, making it valuable for studies related to inflammation and related pathologies. It has been noted that 5,6-Dehydroarachidonic acid does not influence vascular cell proliferation, highlighting its specificity in research applications. -
5-lipoxygenase Inhibitor
WY-50295 is a selective inhibitor of 5-lipoxygenase, impacting the biosynthesis of leukotrienes. It demonstrates an IC50 of 40 μM in inhibiting LTB4 formation in rat whole blood leukocytes, with an oral ED50 of 18 mg/kg. This compound is valuable for studying asthma and other conditions associated with leukotriene signaling. -
15-Lipoxygenase Inhibitor
Caffeoylcalleryanin is a potent inhibitor of 15-lipoxygenase, exhibiting an IC50 value of 1.59 µM. This compound demonstrates a strong capability to modulate lipid metabolism by inhibiting the action of lipoxygenases, crucial for the biosynthesis of lipid mediators. Caffeoylcalleryanin is suitable for research applications focusing on inflammatory pathways and the study of lipid-related processes. Additionally, it shows no cytotoxic effects, making it a valuable tool for cellular and molecular biology studies. -
5-Lipoxygenase Inhibitor
AHR-5333 (mandelate) is a selective inhibitor of 5-lipoxygenase, targeting human blood neutrophils. This compound demonstrates robust and sustained activity in vivo, particularly in models of immediate hypersensitivity in rats and guinea pigs. AHR-5333 (mandelate) is valuable for research applications exploring inflammatory responses and allergic reactions. -
Leukotriene/5-lipoxygenase Inhibitor
L-656224 is a potent and selective inhibitor of leukotriene biosynthesis, acting primarily on 5-lipoxygenase. Demonstrating strong inhibitory activity in both intact rat and human leukocytes as well as CXBG mastocytoma cells (IC50 values ranging from 18 to 240 nM), it significantly impacts human and porcine leukocyte 5-lipoxygenase with an IC50 of 4 x 10^-7 M. This compound shows potential for research applications in asthma and the development of peripheral analgesic agents. -
5-lipoxygenase Inhibitor
CJ-13,610 hydrochloride is a potent and orally active nonredox-type inhibitor of 5-lipoxygenase, exhibiting an IC50 value of 0.07 μM. By competing with activating lipid hydroperoxides at a key regulatory binding site, it effectively prevents 5-lipoxygenase catalysis. This reagent is valuable for research into conditions associated with increased 5-lipoxygenase activity, including inflammatory disorders, allergic asthma, cancer, and atherosclerosis. -
5-LOX/MAO Inhibitor
5-LOX/MAOs-IN-1 is a dual inhibitor of 5-lipoxygenase (5-LOX) and monoamine oxidases (MAOs), exhibiting potent antioxidant properties through free radical scavenging. This compound demonstrates neuroprotective effects in cell models subjected to oxidative stress and promotes a supportive microenvironment for neurogenesis in adult mouse neural stem cells. 5-LOX/MAOs-IN-1 is suitable for research focused on neurodegenerative diseases and mechanisms of neuroprotection. -
5-lipoxygenase Inhibitor
Fluindione is a potent inhibitor of 5-lipoxygenase, exhibiting an IC50 of 15 μM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research in the study of inflammatory pathways and related diseases. Its inhibition of leukotriene synthesis further supports its application in exploring potential therapeutic interventions for conditions characterized by excessive inflammation. -
Lipoxygenase Inhibitor
MLS000536924 is a selective inhibitor of human epithelial 15-lipoxygenase-2, exhibiting competitive inhibition with over 50-fold selectivity. This compound plays a crucial role in exploring the biological functions of h15-LOX-2 and is particularly relevant in research areas including atherosclerosis, cystic fibrosis, and ferroptosis. The binding mechanism of MLS000536924 demonstrates significant restriction of protein mobility, confirming its enhanced biological efficacy compared to other lipoxygenase inhibitors. -
Lipoxygenase
AA863 is a selective inhibitor of 5-lipoxygenase, which plays a crucial role in the metabolism of arachidonic acid and the production of leukotrienes. This compound demonstrates significant dose-dependent inhibition of human glioma cell proliferation, with an IC50 value of 9.0 micromolar in monolayer cultures. AA863 is a valuable tool for researchers investigating glioma biology and the therapeutic potential of targeting lipoxygenase pathways. -
Lipoxygenase Substrate
1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol serves as a substrate for lipoxygenase enzymes, playing a critical role in the formation of bioactive lipids. This compound is involved in various biological processes, including inflammation and cellular signaling pathways. Its application in research includes studies on lipid metabolism and the role of lipoxygenases in disease models. -
12/15-LOX Inhibitor
MLS000099089 is a potent inhibitor of 12/15-lipoxygenase (12/15-LOX), demonstrating IC50 values of 3.4 μM for human and 10 μM for murine 12/15-LOX. This compound exhibits notable selectivity for 12/15-LOX over 5-LOX and COX-2, making it a valuable tool for research. MLS000099089 is applicable in studies related to stroke and other pathophysiological conditions involving lipoxygenase pathways. -
5-lipoxygenase Inhibitor
Enazadrem phosphate is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes. By inhibiting this target, Enazadrem phosphate exhibits significant anti-inflammatory activity, making it a valuable tool for research into inflammatory diseases and related pathways. Its application in preclinical studies may further elucidate the role of leukotrienes in various inflammatory conditions. -
5-lipoxygenase Inhibitor
Bay-y-1015 is an orally active quinoline-based inhibitor of 5-lipoxygenase, effectively blocking the synthesis of leukotrienes such as LTB4 and LTC4. This compound is valuable for research focused on inflammatory diseases, providing insights into mechanisms underlying inflammation and potential therapeutic approaches. -
Antioxidant/Lipoxygenase Inhibitor
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is a potent antioxidant and lipoxygenase inhibitor derived from Parinari hypochrysea, a member of the Chrysobalanaceae family. This compound effectively mitigates oxidative stress and reduces lipoxygenase activity, making it valuable in studies related to inflammation and oxidative damage. Its biological activities support its application in pharmacological research focused on developing anti-inflammatory therapeutics.
