Catalog No.
Product Name
Application
Product Information
Citations
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Lipoxygenase Inhibitor
ICI 198615 is a potent inhibitor of lipoxygenase, targeting the enzymes involved in the metabolism of eicosanoids. By inhibiting lipoxygenase activity, ICI 198615 effectively attenuates the early phase of bronchoconstriction induced by endothelin-1 (ET-1). This compound is useful for research focused on respiratory disorders and inflammatory responses related to eicosanoid signaling pathways. -
Lipoxygenase Inhibitor
tHGA is a potent lipoxygenase inhibitor with demonstrated anti-inflammatory properties. It effectively inhibits soybean 15-lipoxygenase (15-LOX) with an IC50 of 0.42 μM and exhibits concentration-dependent inhibition of 5-lipoxygenase (5-LOX) product synthesis, particularly cysteine leukotriene LTC(4), with an IC50 of 1.80 μM. Notably, tHGA shows no cytotoxicity and operates through a dual inhibition mechanism targeting both LOX and COX-2, with enhanced selectivity for 5-LOX and COX-2 (IC50 of 0.40 μM). This compound is valuable for research applications focused on inflammatory processes and lipoxygenase-related signaling pathways. -
5-LOX Antagonist
ALR-38 is a selective 5-lipoxygenase (5-LOX) antagonist with an IC50 value of 1.1 μM, demonstrating significant anti-inflammatory properties. This compound effectively lowers reactive oxygen species (ROS) levels in neutrophils, making it valuable for research into inflammation and related pathological conditions. ALR-38 serves as a potential tool for studying the role of 5-LOX in inflammatory responses and developing therapeutic strategies. -
LOX Inhibitor
CCT365623 is a selective lipoxygenase (LOX) inhibitor with an IC50 of 0.9 μM. It demonstrates significant anti-metastatic activity in vivo, making it a valuable tool for cancer research. This compound can be utilized to investigate the role of LOX in tumor progression and to explore potential therapeutic approaches targeting metastasis. -
Lipoxygenase Inhibitor
Cgp 8065 is a selective inhibitor of 5-lipoxygenase, a key enzyme involved in the metabolism of arachidonic acid to leukotrienes. By inhibiting this enzyme, Cgp 8065 exerts significant anti-inflammatory effects, making it a valuable tool for studies related to asthma, allergic responses, and other inflammatory diseases. This reagent is suitable for exploring the biochemical pathways associated with lipoxygenase activity and for evaluating potential therapeutic targets in related conditions. -
5-Lipoxygenase Inhibitor
L 670630 is a potent, orally active inhibitor of 5-lipoxygenase, exhibiting an IC50 of 23 nM. This compound effectively modulates the biosynthesis of leukotrienes, which are involved in inflammatory responses. L 670630 is utilized in research applications focused on chronic inflammatory diseases and asthma, providing a valuable tool for studying the role of leukotrienes in these conditions. -
Lipoxygenase
L-691831 is a potent ligand for the 5-lipoxygenase activating protein (FLAP). It is primarily utilized in binding assays to explore FLAP-related activities, particularly in leukocyte membranes. This compound enables the measurement of FLAP affinity for leukotriene synthesis inhibitors, providing insights into the mechanisms of leukotriene production and potential therapeutic targets in inflammatory conditions. -
5-Lipoxygenase Inhibitor
Sigmoidin B is a selective inhibitor of 5-lipoxygenase, targeting the leukotriene synthesis pathway. This prenylated flavanone exhibits significant antioxidant activity by effectively scavenging DPPH radicals. Additionally, Sigmoidin B demonstrates antigenotoxic effects, notably inhibiting genotoxicity induced by Aflatoxin B1 with an IC50 of 18.7 μg/mL, and possesses anti-inflammatory properties. Its diverse biological activities make it a valuable reagent for research in inflammation and oxidative stress-related studies. -
5-lipoxygenase Inhibitor
15(S)-HEDE is a potent inhibitor of 5-lipoxygenase, demonstrating an IC50 value of 26 μM. This compound functions by inhibiting the enzymatic activity associated with leukotriene synthesis, making it a valuable tool for studying inflammatory diseases. Researchers can utilize 15(S)-HEDE to explore pathways related to inflammation and potential therapeutic interventions. -
5-lipoxygenase Inhibitor
SC-45662 is a selective inhibitor of 5-lipoxygenase, a key enzyme involved in leukotriene biosynthesis. This compound effectively suppresses the activation of monocytes in response to phytohemagglutinin (PHA) and reduces superoxide production in neutrophils, highlighting its potential impact on inflammation. SC-45662 has also demonstrated the ability to ameliorate early alterations in lung mechanics and alleviate pulmonary hypertension in sheep models of compromised lung function. Its applications include research into immune system disorders, respiratory diseases, and related pathological conditions. -
Lipoxygenase Inhibitor
Myxochelin A is a potent lipoxygenase inhibitor derived from the microbial metabolite of A. disciformis. It demonstrates significant antibacterial activity against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, while exhibiting no activity against Gram-negative bacteria or fungi in agar diffusion assays. Additionally, Myxochelin A inhibits 5-lipoxygenase (5-LO) with an IC50 of 1.9 μM for recombinant human enzymes and shows cytotoxic effects on 26-L5 colon cancer cells at a concentration of 3 μg/mL, making it a valuable compound for research in inflammation and cancer biology. -
15-Lipoxygenase-1 Inhibitor
BLX-2477 is a potent and selective inhibitor of 15-lipoxygenase-1 (15-LOX-1), demonstrating an IC50 value of 99 nM. This compound effectively inhibits the production of inflammatory lipid mediators, including 15-hydroxy-eicosatetraenoic acid (15-HETE). BLX-2477 is suitable for research applications in the fields of inflammation and immunology, facilitating the study of related biological processes and potential therapeutic interventions. -
5-Lipoxygenase Inhibitor
L 691816 is a potent and selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes. This compound exhibits significant anti-inflammatory activity, making it relevant for research applications focused on allergies and asthma. Its oral bioavailability supports various in vivo studies aimed at elucidating the role of leukotrienes in inflammatory conditions. -
5-LOX Inhibitor
(1Z)-Atractylodinol is identified as a weak inhibitor of 5-lipoxygenase (5-LOX), demonstrating an IC50 value of 17.8 μM. This compound is valuable for research focused on inflammatory diseases, providing insights into the mechanisms of inflammation and potential therapeutic targets. Its role in modulating leukotriene synthesis makes it a relevant tool for those investigating 5-LOX-related pathways in various biological contexts. -
h15-LOX-2 Inhibitor
h15-LOX-2 inhibitor 1 is a selective inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), demonstrating an IC50 value of 0.34 μM. This compound effectively modulates lipid metabolism and inflammatory processes, making it a valuable tool for research into the role of h15-LOX-2 in various biological systems. It is suitable for studies related to inflammation, cancer, and cardiovascular disease. -
Lipoxygenase Inhibitor
Setileuton tosylate is a potent inhibitor of 5-lipoxygenase, effectively blocking the oxidation of arachidonic acid by recombinant human 5-LO. This compound demonstrates significant activity in reducing the production of leukotriene B4 (LTB4) in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. Setileuton tosylate is valuable in research applications related to inflammatory pathways and leukotriene synthesis. -
Lipoxygenase Inhibitor
FLM-5011 is a selective lipoxygenase inhibitor that demonstrates protective effects against myocardial ischemia injury while exhibiting anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and cardiovascular diseases, including myocarditis, by modulating lipoxygenase pathways. -
5-lipoxygenase Inhibitor
CBS-1114 hydrochloride is a potent 5-lipoxygenase inhibitor that plays a critical role in modulating inflammatory pathways. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research focused on inflammation and related disorders. Its ability to selectively inhibit 5-lipoxygenase positions it as an important reagent for studies investigating the underlying mechanisms of inflammation and potential therapeutic strategies. -
Lipoxygenase Inhibitor
RG 6866 is a potent inhibitor of 5-lipoxygenase (5-LOX), aimed at modulating inflammatory responses in cardiac tissues. This compound demonstrates the capacity to alleviate coronary artery constriction and mitigate negative inotropic effects during cardiac inflammatory states. RG 6866 effectively blocks antigen-induced reductions in coronary flow, making it a valuable tool for research in cardiovascular biology and inflammation studies. -
h15-LOX-2 Inhibitor
h15-LOX-2 inhibitor 3 is a selective inhibitor of the enzyme h15-LOX, demonstrating an IC50 of 25 μM and a Ki of 15.1 μM. This compound is utilized in research applications focused on investigating the role of h15-LOX in inflammatory processes and related diseases. Its inhibitory activity provides valuable insights into therapeutic strategies for modulating lipid metabolism and inflammatory signaling pathways. -
5-lipoxygenase Inhibitor
A-78773 is a potent inhibitor of 5-lipoxygenase, demonstrating significant inhibition of leukotriene B4 (LTB4) production in human whole blood and neutrophils, with IC50 values of 85 nM and 20 nM, respectively. This compound is valuable for research into inflammation-related diseases, providing insights into leukotriene-mediated pathways and potential therapeutic interventions. -
5-LOX Inhibitor
Zileuton sulfoxide is a selective inhibitor of lipoxygenase 5-LOX, targeting the lipoxygenase pathway involved in inflammatory responses. It exhibits significant anti-asthmatic properties, making it valuable in studying respiratory conditions and related inflammatory diseases. This compound is useful for research applications focusing on the modulation of leukotriene biosynthesis and understanding the role of 5-LOX in various pathological processes. -
5-lipoxygenase Inhibitor
L-651392 is a selective inhibitor of 5-lipoxygenase, effectively blocking the synthesis of leukotrienes. This compound demonstrates significant anti-inflammatory properties, particularly in the context of Escherichia coli pyelonephritis, by hindering the migration of inflammatory cells to the infection site and safeguarding renal tubules from inflammation-induced damage. L-651392 serves as a valuable tool for research focused on inflammatory processes and renal pathologies. -
5-lipoxygenase Inhibitor
A-79175 is a potent inhibitor of 5-lipoxygenase, a key enzyme involved in the synthesis of leukotrienes. By suppressing leukotriene formation, A-79175 demonstrates significant potential for the investigation of various allergic and inflammatory conditions, such as asthma, allergic rhinitis, rheumatoid arthritis, and inflammatory bowel disease. Its mechanism of action makes it a valuable tool for research in the field of immunology and inflammation. -
Lipoxygenase
(E)-L-652343 is a selective inhibitor of lipoxygenase pathways, demonstrating potent activity against cyclooxygenase and 5-lipoxygenase. This compound effectively reduces the synthesis of inflammatory products associated with these pathways in vivo. Additionally, (E)-L-652343 displays high sensitivity and specificity for detecting geometric isomers in both canine and human plasma, with a notable difference in the elimination rates of its E and Z isomers. Its selective metabolism further supports its utility in biochemical research and therapeutic applications targeting inflammatory disorders. -
Lipoxygenase Inhibitor
LP117 is a potent inhibitor of 5-Lipoxygenase (5-LO), demonstrating an IC50 value of 1.1 μM. This compound impedes the synthesis of 5-LO products, thereby regulating inflammatory pathways. LP117 is applicable in research focused on inflammatory diseases, asthma, and other conditions influenced by leukotriene metabolism. Its selectivity and efficacy make it a valuable tool for studying lipoxygenase-related mechanisms in biological systems. -
Lipoxygenase Inhibitor
Lagunamycin is a selective inhibitor of 5-lipoxygenase, derived from the culture medium of Streptomyces sp. AA0310. It demonstrates significant inhibitory activity with an IC50 value of 6.08 μM against rat 5-lipoxygenase, effectively preventing leukotriene biosynthesis. Notably, lagunamycin achieves this inhibition without inducing lipid peroxidation, making it a valuable tool for studying inflammatory processes and potential therapeutic applications in conditions mediated by 5-lipoxygenase activity. -
Lipoxygenase Inhibitor
BI-L-357 is a lipoxygenase inhibitor that serves as a precursor derived from BI-L-226. It enhances oral bioavailability and effectively inhibits 5-lipoxygenase-mediated leukotriene production, making it a valuable tool for research focused on inflammatory responses and related signaling pathways. This compound's ability to modulate leukotriene levels offers significant potential in studies investigating asthma, allergic reactions, and other inflammatory disorders. -
5-lipoxygenase Inhibitor
Fenleuton is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the synthesis of leukotrienes. By blocking this pathway, Fenleuton demonstrates significant potential for the study of leukotriene-mediated inflammatory diseases, particularly in exploring its role in asthma, rheumatoid arthritis, and other inflammatory conditions. This reagent is valuable for researchers investigating therapeutic strategies targeting leukotriene-related pathways. -
5-lipoxygenase Inhibitor
SB 210661 is a potent and selective inhibitor of 5-lipoxygenase, a key enzyme involved in the biosynthesis of leukotrienes. By inhibiting this enzyme, SB 210661 modulates inflammatory responses and has potential applications in the study of asthma, arthritis, and other inflammatory diseases. This compound serves as a valuable tool for researchers investigating the role of leukotrienes in various biological processes. -
Lipoxygenase
Leukotriene A 3 methyl ester is a lipoxygenase metabolite derived from 5,8,11-eicosatrienoic acid through the 5-lipoxygenase (5-LO) pathway. This compound exhibits significant biological activity, particularly in the modulation of inflammatory responses and immune cell signaling. It is commonly used in research applications focused on leukotriene biosynthesis and related inflammatory processes. -
Lipoxygenase Inhibitor
CMI977 is a potent inhibitor of 5-Lipoxygenase (5-LO), an enzyme involved in the biosynthesis of leukotrienes. By effectively inhibiting 5-LO, CMI977 demonstrates significant anti-inflammatory properties, making it a valuable tool for research in inflammation and related diseases. Its application extends to studies focused on the modulation of leukotriene-mediated pathways, providing insights into targeted therapies for various inflammatory conditions. -
5-Lipoxygenese/PAF Receptor Antagonist
CMI-392 is a dual inhibitor of 5-lipoxygenase and a platelet-activating factor (PAF) receptor antagonist, exhibiting IC50 values of 100 nM and 10 nM, respectively. This compound demonstrates significant anti-inflammatory activities by modulating leukotriene synthesis and PAF signaling pathways. CMI-392 is valuable for research applications focused on inflammatory diseases and related therapeutic targets. -
Lipoxygenase Inhibitor
AZD 4407 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research in areas such as asthma, arthritis, and other inflammatory diseases. AZD 4407 is utilized to study the modulation of leukotriene-mediated pathways in various biological contexts. -
LOX-1 Inhibitor
BI-0115 is a selective LOX-1 inhibitor with an IC50 of 5.4 μM, effectively blocking the cellular uptake of oxidized low-density lipoprotein (oxLDL). This compound disrupts receptor activity through the formation of dimers within the homodimeric ligand binding domain. BI-0115 is valuable for research focused on atherosclerosis and cardiovascular diseases, providing insight into the modulation of lipid metabolism and inflammatory processes. -
LOX-1 Inhibitor
DKI5, or (E)-N’-benzylidenehydrazinecarbothiohydrazide, is a selective inhibitor of LOX-1, with an IC50 value of 22.5 μM. This compound demonstrates potential anti-inflammatory properties by targeting the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). DKI5 is suitable for research applications involving cardiovascular studies and the modulation of atherosclerosis-related pathways. -
LXR Degrader
GAC0003A4 is an LXR (liver X receptor) degrader that inhibits LXR transcriptional activity. It effectively promotes the degradation of LXRβ protein, thereby decreasing its biological function. This compound shows potential for research applications in advanced pancreatic cancer and other refractory malignancies, making it a valuable tool for studying LXR-related pathways in cancer biology. -
Phospholipase Inhibitor
ML-211 is a carbamate-based inhibitor targeting acyl-protein thioesterase 1 (APT1) and lysophospholipase 1 (LYPLA1), with an IC50 of 17 nM, as well as lysophospholipase 2 (LYPLA2) with an IC50 of 30 nM. Additionally, it inhibits the serine hydrolase ABHD11 at an IC50 of 10 nM while demonstrating greater than 50-fold selectivity for LYPLA in a diverse panel of 20 serine hydrolases. ML-211 is valuable for research involving lipid metabolism and signaling pathways, particularly those associated with phospholipase activity. -
CYP11B1/CYP11B2 Inhibitor
Osilodrostat phosphate is a selective inhibitor of 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), demonstrating an IC50 of 35 nM and 0.7 nM, respectively, for human enzymes. This compound effectively inhibits the synthesis of aldosterone and corticosterone, contributing to its role in blood pressure regulation. Osilodrostat phosphate is particularly valuable for research investigating Cushing syndrome and related disorders involving dysregulated steroidogenesis. -
Chelating Agent, Mitochondrial Electron Transport Chain Inhibitor, Carboxylesterase Inhibitor
2-Thenoyltrifluoroacetone is a chelating agent that targets the mitochondrial electron transport chain, exhibiting an IC50 value of 51.5 μM. It effectively chelates various metal ions and demonstrates cytotoxicity along with anti-tumor activity. This compound holds potential for applications in the treatment of diseases linked to mitochondrial dysfunction, contributing valuable insights into related therapeutic strategies. -
Herbicide
Simeton is a methoxy-5-triazine herbicide that targets photosynthesis in plants, effectively inhibiting weed growth in various agricultural settings. Its primary application is in the control of broadleaf and grassy weeds in crops such as corn, wheat, maize, and barley. This compound plays a vital role in enhancing crop yield by minimizing competition from undesired vegetation. -
Herbicide
Epopromycin B is a herbicide that acts by inhibiting cell wall synthesis in lettuce protoplasts, demonstrating significant herbicidal activity. In addition to its agricultural applications, Epopromycin B displays cytotoxic effects in B16 melanoma cells, with an IC50 value of 0.003 µg/mL, highlighting its potential for further research in cancer biology. -
Herbicide
Chloridazon is a selective herbicide that inhibits photosynthesis by targeting the D1 protein in the photosystem II complex. It exhibits significant herbicidal activity against a broad spectrum of annual and perennial weeds. Research applications include studies on plant physiology and environmental impact assessments of herbicide use. The compound has an LD50 value of 76.6 ppm, indicating its level of genotoxicity in assays. -
Herbicide
Dithiopyr is a selective herbicide targeting major grassy weeds and small-seeded broadleaf weeds. It exerts its effects through pre-emergence or early post-emergence application, disrupting weed establishment and growth. This compound is widely utilized in agricultural research to develop effective weed management strategies. -
Herbicide
5,6-Bis(4-methoxyphenyl)-2,3-diphenylthieno[3,2-b]furan acts as a selective herbicide targeting various plant species. This compound demonstrates significant herbicidal activity by disrupting key biological pathways involved in plant growth and development. It is applicable in agricultural research and studies focused on weed management strategies. -
Herbicide
Napropamide-M is a selective herbicide that targets the growth of various broadleaf and grassy weeds in winter oilseed rape and brassica vegetable crops. It functions by inhibiting cell division, ultimately disrupting plant growth. Its efficacy makes it a valuable tool for agricultural research and crop management practices. -
Herbicide
Metazosulfuron is an acetolactate synthase (ALS) inhibitor serving as an effective herbicide. It is specifically designed for the control of pondweed (Potamogeton nodosus) and effectively prevents its regrowth in transplanted rice systems. Additionally, Metazosulfuron contributes to enhanced yields of rough rice grain, supporting agricultural productivity. -
Corn Herbicide
Tolpyralate is a selective post-emergence herbicide that functions primarily by inhibiting the enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD). This compound demonstrates potent herbicidal activity against a range of weed species, including the glyphosate-resistant Amaranthus tuberculatus. Tolpyralate is essential for agricultural research and weed management strategies in corn cultivation. -
Herbicide
Cis-2-Amino-1-hydroxycyclobutane-1-acetic acid is a herbicidal antimetabolite that targets amino acid biosynthesis pathways, leading to chlorosis in Arabidopsis thaliana. This compound acts by interfering with the synthesis of essential metabolites, specifically causing reversible symptoms associated with L-cysteine or L-methionine depletion. It is valuable in research applications focused on understanding herbicide mechanisms and plant response to metabolic stress. -
Herbicide
Butroxydim is an acetyl-coenzyme A carboxylase (ACCase) inhibitor utilized as a selective herbicide. This compound effectively targets and controls herbicide-resistant populations of Hordeum leporinum, demonstrating significant efficacy against strains resistant to other ACCase inhibitors. It is therefore valuable for researchers studying herbicide resistance mechanisms and developing effective weed management strategies.
