Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
D-Leucine is an endogenous metabolite that acts as a potent anti-seizure agent. It effectively terminates seizure activity even after onset, making it a valuable compound for seizure research. Additionally, D-leucine demonstrates a significant reduction in long-term potentiation without affecting basal synaptic transmission in vitro, offering insights into its mechanism in synaptic plasticity and neurotransmission pathways. -
Endogenous Metabolite
H-Asn(glcnac-beta-D)-OH is an endogenous metabolite that primarily targets N-glycan metabolism. This compound is significant for research into the NGLY1-CDDG, serving as a valuable tool for understanding glycosylation disorders. Its presence in urine offers insights into metabolic pathways and potential diagnostic applications. -
Endogenous Metabolite
3-Hydroxysebacic acid is an endogenous metabolite that plays a role in various metabolic pathways. It is primarily utilized in research related to Medium Chain Acyl-CoA Dehydrogenase Deficiency, a condition linked to fatty acid oxidation disorders. The compound may aid in understanding metabolic dysregulation and the biochemical alterations associated with this deficiency. -
Endogenous Metabolite
(S)-3-Hydroxybutanoic acid targets metabolic pathways as an endogenous metabolite. It plays a role in energy metabolism, being synthesized in the liver from acetyl-CoA and serving as an alternative energy source for the brain during periods of low blood glucose. Additionally, this compound is associated with depression and may serve as a potential biomarker for this condition in research applications. -
Endogenous Metabolite
2,5-Dimethylpyrazine is an endogenous metabolite characterized by its role in the flavor profile of food systems, particularly in whey protein hydrolysates derived from trypsin or proteinase enzymes. This compound can be qualitatively analyzed using stable isotope dilution assays and is also produced through microbial fermentation by Bacillus subtilis. Furthermore, 2,5-Dimethylpyrazine can undergo oxidation to generate 5-methylpyrazine-2-carboxylic acid, an important intermediate in the synthesis of antilipolytic agents. Known for its distinctive roasted peanut flavor, this volatile compound has significant implications in food science and flavor research. -
Endogenous Metabolite
N1,N8-Diacetylspermidine hydrochloride is an endogenous metabolite that serves as a biomarker in cancer research. This compound is involved in polyamine metabolism and is found in human urine. It is particularly valuable as a prognostic indicator for monitoring cancer treatment outcomes and conducting follow-up examinations in patients. -
Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid, also known as (+)-(R)-Proline, is an endogenous metabolite that plays a crucial role in amino acid metabolism. This compound exhibits significant renal and hepatotoxic effects in experimental models, making it valuable for research into amino acid metabolism and associated toxicity mechanisms. Its applications include investigations of metabolic pathways and the effects of amino acid dysregulation on cellular health. -
FXR Antagonist
Tauro-α-muricholic acid sodium is a sodium salt of a taurine-conjugated primary bile acid that functions as an antagonist of the farnesoid X receptor (FXR) with an IC50 of 28 µM. This compound effectively inhibits FXR signaling mediated by other bile acids. Research applications include studies on Alzheimer's disease, glucose metabolism, and lipid metabolism, providing valuable insights into metabolic regulation and related disorders. -
Endogenous Metabolite
4-Methoxycinnamic acid is an endogenous metabolite belonging to the class of phenylpropanoids. It exhibits biological activities including antioxidant and anti-inflammatory properties, making it a valuable compound in research focused on metabolic pathways and natural product chemistry. This compound is commonly studied for its role in plant defense mechanisms and its potential therapeutic applications in various diseases. -
Cysteinyl Leukotriene Pathway Marker
Leukotriene E4 (LTE4) serves as a marker in the cysteinyl leukotriene pathway, produced through the enzymatic conversion of leukotriene D4 (LTD4) by dipeptidase. This compound is a key component of the slow-reacting substance of anaphylaxis (SRS-A) and has been implicated in various inflammatory responses. Elevated urinary levels of leukotriene E4 are commonly utilized as a biomarker for asthma, making it valuable in both clinical and research applications related to respiratory diseases and allergic reactions. -
Endogenous Metabolite
H-HoArg-OH is an endogenous metabolite that acts as a potent inhibitor of human bone and liver alkaline phosphatase. This compound is valuable for investigating the role of alkaline phosphatase in bone and liver metabolism, providing insights into various biological processes and diseases. Its inhibitory properties make it a useful tool for studying related enzymatic pathways in biochemical research. -
Endogenous Metabolite
18:0,18:1 PS sodium is a phospholipid that plays a crucial role in the structure and function of synaptic vesicles and cholesterol metabolism. It is commonly utilized in metabolic research to investigate lipid interactions and cellular signaling pathways. This compound serves as an important tool for studying synaptic transmission and the biochemical networks associated with lipid metabolism. -
Endogenous Metabolite
N-Oleoyl Taurine is an endogenous metabolite that acts as an amino-acyl endocannabinoid. It is known to activate transient receptor potential (TRP) channels, specifically TRPV1 and TRPV4, implicating its role in calcium signaling. This compound has been isolated from rat brain and presents potential applications in research studying the physiological effects of TRP channel modulation and its involvement in neurological functions. -
Endogenous Metabolites
Methyl acetylacetate is a chemical reagent that serves as a versatile building block in the synthesis of α-substituted acetoacetates and cyclic compounds, including pyrazole, pyrimidine, and coumarin derivatives. This compound is particularly valuable in pharmaceutical research and holds potential for investigating inflammatory diseases, contributing to the understanding of metabolic pathways and disease mechanisms. -
Biochemical Assay Reagent
3-Penten-2-one is a biochemical assay reagent that modulates nitric oxide production by inhibiting inducible nitric oxide synthase expression. This compound exerts its effects through the induction of heme oxygenase-1 in RAW264.7 macrophages activated by lipopolysaccharides (LPS). Its applications extend to studies involving inflammatory responses and the regulation of oxidative stress. -
Endogenous Metabolite
N-Acetylmannosamine 6-phosphate sodium salt is an endogenous metabolite that serves as a key metabolic intermediate in the degradation of sialic acid (Neu5Ac) by Staphylococcus aureus. This compound diminishes the affinity of the transcriptional regulator NanR for DNA, thereby modulating the metabolic pathway associated with sialic acid. It is useful for studies examining sialic acid metabolism and its regulatory mechanisms in microbial organisms. -
Endogenous Metabolite
(S)-(+)-1,2-Propanediol is an endogenous metabolite known for its role in various metabolic pathways. It serves as an organic solvent and diluent in pharmaceutical formulations and is utilized as a chiral synthetic intermediate in organic chemistry. Additionally, (S)-(+)-1,2-Propanediol is a valuable substrate for enzyme research, facilitating studies on enzyme kinetics and activity. -
Endogenous Metabolite
DL-Homocystine is a double-bonded derivative of homocysteine, serving as an endogenous metabolite. It is implicated in the pathogenesis and pathophysiology of schizophrenia, making it a relevant compound for research into neurodevelopmental disorders. This substance can provide insights into the biochemical mechanisms associated with mental health conditions and may aid in the exploration of potential therapeutic targets. -
Endogenous Metabolite
Sodium 2-hydroxybutanoate is an endogenous metabolite that plays a crucial role in cellular metabolism. It is involved in various biochemical pathways, including energy production and amino acid metabolism. This compound is primarily utilized in research applications studying metabolic processes and investigating disorders related to cellular energy regulation. -
Endogenous Metabolite
D(-)-2-Aminobutyric acid is an endogenous metabolite that serves as a substrate for D-amino acid oxidase. This compound is involved in various metabolic pathways and has been studied for its potential roles in neurological functions and disorders. Its application in research includes investigations into metabolic processes and the modulation of neurotransmitter activity. -
Endogenous Metabolite
Cytidine-5'-triphosphate disodium dihydrate (5'-CTP disodium dihydrate) is an endogenous metabolite that functions as a high-energy coenzyme in critical biological processes. It plays a vital role in glycerophospholipid biosynthesis and protein glycosylation, facilitating cellular membrane dynamics and post-translational modifications. This compound is valuable for research applications studying metabolic pathways, cellular signaling, and the synthesis of nucleotides and lipids. -
Endogenous Metabolite
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE is a plasmalogen composed of 1(Z)-octadecenoic acid and arachidonic acid at the sn-1 and sn-2 positions, respectively. This compound acts as an endogenous metabolite and is essential for maintaining membrane integrity and fluidity. It plays a critical role in signaling pathways and lipid metabolism, making it a valuable tool for research in cell biology, neurobiology, and inflammation studies. -
Endogenous Metabolite
AubipyOMe is a selective inhibitor of tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme implicated in osteoclast and macrophage activity. It exhibits IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b, effectively inhibiting TRAP activity in murine macrophage extracts and human lung tissue. This compound is valuable for studying bone resorption and macrophage function in various biological contexts. -
Endogenous Metabolite
Mevalonic acid 5-pyrophosphate tetralithium is an endogenous metabolite involved in the mevalonate pathway, which plays a crucial role in synthesizing isoprenoids and cholesterol. This compound is pertinent for research into metabolic processes and the regulation of lipid biosynthesis. Its use can facilitate the study of cellular signaling and metabolism, enhancing understanding of various biological systems and disease states. -
Endogenous Metabolite
CRCD2 is a small molecule inhibitor of the nucleotidase NT5C2, enhancing the cytotoxic effects of 6-mercaptopurine. It effectively reverses resistance to 6-mercaptopurine caused by NT5C2 gene mutations or non-genetic mechanisms. When used in combination with 6-mercaptopurine, CRCD2 enhances cytotoxic activity in NT5C2 wild-type leukemia, indicating its potential as a therapeutic agent in the treatment of acute lymphoblastic leukemia. -
Endogenous Metabolite
Dibenzyl disulfide is an endogenous metabolite that plays a significant role in various biological processes. This compound exhibits antioxidant properties and may contribute to cellular defense mechanisms. It is utilized in research to explore metabolic pathways and the biochemical impacts of sulfur-containing compounds in biological systems. -
Endogenous Metabolite
(R)-(-)-1,3-Butanediol is the R-enantiomer of 1,3-Butanediol, functioning as an endogenous metabolite. It demonstrates anti-diabetic properties in animal models, showcasing potential for metabolic regulation. This compound is also utilized in the flavoring and fragrance industries, contributing to the modulation of carbohydrate and lipid metabolism in biological systems. Its diverse applications make it a valuable reagent for research in metabolic studies. -
Endogenous Metabolite
3-Oxo-4,6-choladien-24-oic acid is an endogenous metabolite associated with hepatobiliary disease. This compound is typically found in the urine of affected individuals and serves as a potential biomarker for liver function. Its study may contribute to the understanding of metabolic pathways and disease mechanisms related to liver health. -
Endogenous Metabolite
8-Isoprostaglandin F2α is an isoprostane resulting from the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. This compound exists in human plasma in two forms: esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α functions primarily as a weak thromboxane receptor (TP) agonist in vascular smooth muscle, making it relevant in studies of vascular biology and cardiovascular research. -
Endogenous Metabolite
L-Lysine hydrate is an essential amino acid that acts as an endogenous metabolite. It plays a crucial role in protein synthesis and is implicated in various biological processes. Research applications include studies on vascular calcification and acute pancreatitis, making it a valuable reagent for investigating metabolic disorders and related pathologies. -
Endogenous Metabolite
α-D-Glucose-1-phosphate disodium hydrate serves as a crucial endogenous metabolite, acting primarily as a building block in the synthesis of glucuronic acid. This compound exhibits cytostatic properties, making it essential for cardiopathic therapy, while also demonstrating potential as an antibiotic and immunosuppressive agent. Its versatile applications in circulatory system therapies underscore its significance in various biochemical and pharmaceutical research contexts. -
Endogenous Metabolite
3-Hydroxymandelic Acid is an endogenous metabolite derived from Phenylephrine, which functions as an α-receptor agonist. This compound is instrumental in research related to catecholamine metabolism and autonomic nervous system regulation. It can be utilized for studying the biochemical pathways of adrenergic signaling and the physiological effects of α-receptor activation. -
Endogenous Metabolite
L-Allothreonine is an endogenous metabolite that plays a role in various metabolic pathways. This amino acid is involved in protein synthesis and may influence cellular functions through its contributions to metabolic processes. Research applications include studies on metabolism, amino acid profiling, and investigations into its physiological roles in human health and disease. -
Endogenous Metabolite
L-Prolylglycine is an endogenous metabolite that serves as an important modulator of cellular signaling pathways. This compound is known to exhibit neuroprotective effects and plays a role in cognitive function. It is utilized in research applications focused on neurobiology, metabolism, and the study of related disorders. -
Endogenous Metabolite
3-Amino-4-hydroxybenzoic acid is an endogenous metabolite known for its role in various biochemical pathways. It functions as an intermediate in the synthesis of important compounds such as catecholamines and can influence metabolic processes. This compound is utilized in research applications involving metabolic studies, enzyme activity assessment, and the exploration of its therapeutic potential in various physiological contexts. -
Endogenous Metabolite
ATP dipotassium, or Adenosine 5'-triphosphate dipotassium, serves as a crucial endogenous metabolite involved in energy storage and metabolic processes. It provides the necessary energy for various metabolic pumps and functions as a key coenzyme in cellular activities. Additionally, ATP dipotassium plays a significant role as a signaling molecule in immune responses and inflammatory pathways, making it valuable for research in cellular biology, immunology, and inflammation studies. -
Endogenous Metabolite
alpha-D-glucose, an endogenous metabolite, primarily functions as an essential monosaccharide in glucose metabolism. It exhibits a pronounced insulin-stimulating effect compared to beta-D-glucose, making it critical for studies related to diabetes, carbohydrate metabolism, and insulin signaling pathways. This compound is integral in research exploring energy metabolism and cellular respiration. -
Endogenous Metabolite
2-(2-Methylbenzamido)acetic acid is an endogenous metabolite identified in urine. This compound is significant for its role in metabolic studies and can be used as a biomarker in various physiological and pathological conditions. It serves as a useful tool for researchers examining metabolic profiles and renal function. -
Endogenous Metabolite
1,4-D-Gulonolactone is an endogenous metabolite that serves as a precursor in the biosynthesis of ascorbic acid (vitamin C). It plays a crucial role in redox biology and cellular antioxidant defense mechanisms. This compound is commonly utilized in research to investigate its physiological functions and potential implications in metabolic disorders, aging, and oxidative stress. -
Endogenous Metabolite
Thiotaurine is an endogenous metabolite of cystine that acts as a sulfur donor. It plays a role in modulating the activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is important for neutrophil activation and leukocyte energy metabolism. Thiotaurine exhibits potential anti-inflammatory properties and may serve as an immunomodulator in various biological research applications. -
Endogenous Metabolite
Methylmalonyl-CoA tetralithium is an endogenous metabolite involved in the catabolism of branched-chain amino acids, odd-chain fatty acids, and cholesterol. It acts as a substrate for methylmalonyl-CoA mutase (MCM) in the conversion to succinyl-CoA, a crucial step in cellular energy metabolism. This reagent is valuable in research applications focused on metabolic pathways, mitochondrial function, and the study of related metabolic disorders. -
Endogenous Metabolite
N-Formylglycine, an endogenous metabolite, plays a pivotal role in various biological processes. It is involved in the regulation of cellular metabolism and can act as a precursor in the biosynthesis of important biomolecules. Research applications include studies on metabolic pathways and the exploration of its function in cellular signaling and regulation. -
Endogenous Metabolite
NSC 90469 is an endogenous metabolite involved in various biological processes. It plays a crucial role in metabolic pathways and can be utilized in research applications related to cellular metabolism and biochemical assays. Its investigation aids in understanding metabolic dysregulation in diseases and potential therapeutic targets. -
Endogenous Metabolite
Phenyl acetate is an endogenous metabolite derived from 2-phenylethylamine, commonly found in urine. It plays a role in the regulation of glutamine metabolism and has potential applications in disease detection, particularly in relation to conditions such as depression. Its measurement may serve as a biomarker, offering insights into metabolic disturbances associated with various health conditions. -
Endogenous Metabolite
Euphol is a tetracyclic triterpene alcohol derived from the sap of Euphorbia tirucalli, primarily targeting monoacylglycerol lipase (MGL). This compound exhibits anti-mutagenic, anti-inflammatory, and immunomodulatory properties, making it relevant in pain research and the study of the endocannabinoid system. Euphol reversibly inhibits MGL activity, with an IC50 of 315 nM, thereby modulating inflammatory pain pathways in peripheral tissues. -
Endogenous Metabolite
Palmitoyldocosahexaenoyl phosphatidylcholine is an endogenous metabolite that serves as a critical component of cellular membranes. This compound plays a significant role in promoting membrane fluidity and functionality, influencing various biological processes, including cell signaling and inflammation. Its research applications extend to studies involving lipid metabolism, neuroprotection, and the modulation of inflammatory pathways. -
Endogenous Metabolite
Formiminoglutamic acid is an endogenous metabolite that serves as a potential biomarker of folate deficiency. It is involved in amino acid metabolism and plays a role in the assessment of various metabolic disorders. This compound is particularly useful in research applications focused on understanding folate metabolism and its associated health implications. -
PDE-ALDH7A1 Biomarker
D-6-Oxo-pipecolinic acid is the D-enantiomer of 6-Oxo-pipecolinic acid and serves as a biomarker for pyridoxine-dependent epilepsy (PDE) linked to the ALDH7A1 gene. This compound is crucial for studying the metabolic pathways associated with PDE, facilitating research into neurological disorders and potential therapeutic interventions. Its role as a biomarker allows for better understanding and diagnosis of pyridoxine-dependent epilepsy. -
Endogenous Metabolite
Inosine 5′-diphosphate sodium is an endogenous metabolite that plays a crucial role in intracellular energy metabolism and signal transduction pathways. As a purine ribonucleoside 5′-diphosphate, it serves as a derivative of inosine, facilitating important cellular functions. This compound is employed in research related to nucleotide metabolism, cellular signaling mechanisms, and the modulation of enzymatic activities in various biological systems. -
Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate sodium is an endogenous metabolite that serves as an a-site substrate analogue. It significantly inhibits the reaction rate of indole and nucleophilic indole analogues with E(A-A) upon binding to the a-site. This compound is valuable for studying enzymatic mechanisms and metabolic pathways, particularly those involving glycerol 3-phosphate dehydrogenase and related enzymes in biochemical research.
