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Biological Activity
MCC950 sodium is a potent NLRP3 inflammasome inhibitor that inhibits IL-1beta production with IC50 value of 7.5 nm.
Targets
| NLRP3 | ||||
| 7.5nM |
| In vitro | DMSO | Insoluble | |
| Water | 77 mg/mL (180.55 mM) | ||
| Ethanol | 36 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.45 mL | 117.24 mL | 234.49 mL |
| 0.5 mM | 4.69 mL | 23.45 mL | 46.9 mL |
| 1 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13478 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 256373-96-3 |
| Formula | C20H23N2NaO5S |
| M. Wt | 426.46 |
| Purity | >98% |
| Synonyms | CP-456773 sodium, CP 456773 sodium, CP456773 sodium, MCC 950, MCC-950, CRID-3, CRID3, CRID 3 |
| SMILES | O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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