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Biological Activity
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
| In vitro | DMSO | 91 mg/mL (141.93 mM) | |
| Water | Insoluble | ||
| Ethanol | 12 mg/mL (18.71 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.6 mL | 77.99 mL | 155.98 mL |
| 0.5 mM | 3.12 mL | 15.6 mL | 31.2 mL |
| 1 mM | 1.56 mL | 7.8 mL | 15.6 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.12 mL |
*The above data is based on the productmolecular weight 641.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13129 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1818314-88-3 |
| Formula | C36H33ClN2O7 |
| M. Wt | 641.11 |
| Purity | >98% |
| Synonyms | BMS 1166, BMS1166 |
| SMILES | O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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