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BMS-1166

Catalog No.: A13129

PD-1/PD-L1 interaction inhibitor

BMS-1166

BMS-1166 Chemical Structure

CAS NO. 1818314-88-3

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

Availability: In stock

Package Price Qty
5 mg
$240.00
10 mg
$390.00
50 mg
$1,280.00
100 mg
$2,280.00
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Biological Activity

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
In vitro DMSO 91 mg/mL (141.93 mM)
Water Insoluble
Ethanol 12 mg/mL (18.71 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.6 mL 77.99 mL 155.98 mL
0.5 mM 3.12 mL 15.6 mL 31.2 mL
1 mM 1.56 mL 7.8 mL 15.6 mL
5 mM 0.31 mL 1.56 mL 3.12 mL

*The above data is based on the productmolecular weight 641.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13129
Actions Inhibitor
CAS No. 1818314-88-3
Formula C36H33ClN2O7
M. Wt 641.11
Purity >98%
Synonyms BMS 1166, BMS1166
SMILES O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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