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$0.00 - Chia-Hui Huang, .et al. Arsenic Trioxide-Induced p38 MAPK and Akt Mediated MCL1 Downregulation Causes Apoptosis of BCR-ABL1-positive Leukemia Cells, Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283
Biological Activity
GKT137831 is a first in class inhibitor targeting NOX1 and NOX4 enzymes.
Targets
| NOX1 | NOX4 | |||
| 110 nM(Ki) | 140 nM(Ki) |
| In vitro (25°C) | DMSO | Warmed: 72 mg/mL (182.34 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+2% Tween 80+30% PEG 300+ddH2O | 8 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.33 mL | 126.63 mL | 253.26 mL |
| 0.5 mM | 5.07 mL | 25.33 mL | 50.65 mL |
| 1 mM | 2.53 mL | 12.66 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14433 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1218942-37-0 |
| Formula | C21H19ClN4O2 |
| M. Wt | 394.85 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | GKT-137831, GKT 137831 |
| SMILES | CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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