GKT137831

Catalog No.: A14433

NOX1/4 inhibitor

GKT137831

GKT137831 Chemical Structure

CAS NO. 1218942-37-0

GKT137831 is a first in class inhibitor targeting NOX1 and NOX4 enzymes.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$140.00
25 mg
$320.00
10mM * 1mL in DMSO
$100.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chia-Hui Huang, .et al. Arsenic Trioxide-Induced p38 MAPK and Akt Mediated MCL1 Downregulation Causes Apoptosis of BCR-ABL1-positive Leukemia Cells, Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283

Biological Activity

GKT137831 is a first in class inhibitor targeting NOX1 and NOX4 enzymes.
Targets
NOX1 NOX4
110 nM(Ki)140 nM(Ki)
In vitro (25°C) DMSO Warmed: 72 mg/mL (182.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+2% Tween 80+30% PEG 300+ddH2O 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.33 mL 126.63 mL 253.26 mL
0.5 mM 5.07 mL 25.33 mL 50.65 mL
1 mM 2.53 mL 12.66 mL 25.33 mL
5 mM 0.51 mL 2.53 mL 5.07 mL

*The above data is based on the productmolecular weight 394.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14433
Actions Inhibitor
CAS No. 1218942-37-0
Formula C21H19ClN4O2
M. Wt 394.85
Solubility DMSO
Purity >98%
Synonyms GKT-137831, GKT 137831
SMILES CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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