Entrectinib

Catalog No.: A15801

TRK, ROS1, ALK inhibitor

Entrectinib

Entrectinib Chemical Structure

CAS NO. 1108743-60-7

Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$85.00
25 mg
$160.00
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Biological Activity

Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
Targets
TrkA TrkB TrkC ROS1 ALK
In vitro DMSO 89 mg/mL (158.74 mM)
Water Insoluble
Ethanol 67 mg/mL (119.5 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.18 mL 178.37 mL
0.5 mM 3.57 mL 17.84 mL 35.67 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15801
Actions Inhibitor
CAS No. 1108743-60-7
Formula C31H34F2N6O2
M. Wt 560.64
Purity >98%
Synonyms RXDX-101, RXDX-101, RXDX-101, NMS E628, NMS-E628, NMSE628
SMILES CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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