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Biological Activity
Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
Targets
| TrkA | TrkB | TrkC | ROS1 | ALK |
| In vitro | DMSO | 89 mg/mL (158.74 mM) | |
| Water | Insoluble | ||
| Ethanol | 67 mg/mL (119.5 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.84 mL | 89.18 mL | 178.37 mL |
| 0.5 mM | 3.57 mL | 17.84 mL | 35.67 mL |
| 1 mM | 1.78 mL | 8.92 mL | 17.84 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.57 mL |
*The above data is based on the productmolecular weight 560.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15801 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1108743-60-7 |
| Formula | C31H34F2N6O2 |
| M. Wt | 560.64 |
| Purity | >98% |
| Synonyms | RXDX-101, RXDX-101, RXDX-101, NMS E628, NMS-E628, NMSE628 |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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