Target & Activity
| Target | Activity | Value |
|---|---|---|
| COX-2 | IC50 | 3.8 μM |
Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| A549 | IC50 | 20 μM | Inhibition of mPGES-1 in human A549 cell microsomes assessed as conversion of PGH2 into PGE2 at 0 degC after 5 mins by HPLC-UV analysis | [PMID: 22209272] |
| HaCaT | IC50 | 10 nM | Inhibition of PGE2 production in human HaCaT cells after 24 hrs by RIA | [PMID: 15387642] |
| RAW264.7 | IC50 | > 10 μM | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs by fluorimetry | [PMID: 11678654] |
| RAW264.7 | IC50 | 0.007 μM | Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrs | [PMID: 27720548] |
| RAW264.7 | IC50 | 0.007 μM | Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay | [PMID: 24656662] |
| RAW264.7 | IC50 | 0.00723 μM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production after 24 hrs by enzyme immunoassay | [PMID: 29107425] |
| RAW264.7 | IC50 | 0.05 μM | Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay | [PMID: 19233646] |
| RAW264.7 | IC50 | 0.1 μM | Inhibition of IFN-gamma/LPS-induced PGE2 production in mouse RAW264.7 cells after 17 to 20 hrs by EIA method | [PMID: 25027933] |
| RAW264.7 | IC50 | 0.81 μM | Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay | [PMID: 20056549] |
| RAW264.7 | IC50 | 2.1 μM | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as PGE2 accumulation after 20 hrs by RIA | [PMID: 11678654] |
| RAW264.7 | IC50 | 4.8 μM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production by EIA | [PMID: 20004572] |
| RAW264.7 | IC50 | 6.7 nM | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as decrease in PGE2 production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA | [PMID: 31747281] |
| RAW264.7 | IC50 | 6.74 μM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated PGE2 production by ELISA | [PMID: 28408221] |
| RAW264.7 | IC50 | 63.7 μM | Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassay | [PMID: 20056549] |
| RAW264.7 | IC50 | 7 nM | Suppression of PGE2 production in LPS-induced mouse RAW264.7 cells after 24 hrs by enzyme immunoassay | [PMID: 26602278] |
| RAW264.7 | IC50 | 7.01 nM | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production administered 1 hr prior to LPS-challenge measured after 24 hrs by EIA | [PMID: 24360561] |
| RAW264.7 | IC50 | 7.23 nM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production pretreated for 1 hr followed by LPS addition measured after 24 hrs | [PMID: 29102229] |
| SK-BR-3 | IC50 | 0.68 μM | Inhibition of aromatase in human SKBR3 cells by tritiated water release assay | [PMID: 18271519] |
| SK-BR-3 | IC50 | 0.72 μM | Cytotoxicity against human SK-BR-3 cells after 24 hrs by MTT assay relative to NS398 | [PMID: 17095221] |
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