Fig. 1 · Structure
Documents & Downloads
4-Azidobutylamine
PROTAC Linker
4-Azidobutylamine is a versatile PROTAC linker designed for the synthesis of targeted protein degradation agents. By connecting a ligand for an E3 ubiquitin ligase to a ligand for the target protein, it facilitates the selective degradation of specific proteins via the ubiquitin-proteasome pathway. Additionally, 4-Azidobutylamine contains an azide functional group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. This reagent is crucial for advancing the development of PROTAC-based therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 88192-20-5 |
| Applications | PROTAC Linker |
| Formula | C4H10N4 |
| Molecular Weight | 114.15 |
| SMILES | NCCCCN=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.