Fig. 1 · Structure
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Aeide-C1-NHS ester
PROTAC Linkers
Aeide-C1-NHS ester is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) compounds. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique reactivity profiles make it an ideal candidate for developing innovative tools in targeted protein degradation research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 824426-32-6 |
| Applications | PROTAC Linkers |
| Formula | C6H6N4O4 |
| Molecular Weight | 198.14 |
| SMILES | O=C(ON1C(CCC1=O)=O)CN=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.