Azido-PEG3-NHS ester is a PEG-based PROTAC linker featuring an azide functional group, which facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a versatile click chemistry reagent that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it ideal for targeted protein degradation studies and related applications in chemical biology.
Azido-PEG3-NHS ester is a PEG-based PROTAC linker featuring an azide functional group, which facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a versatile click chemistry reagent that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it ideal for targeted protein degradation studies and related applications in chemical biology.
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