Fig. 1 · Structure
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DBCO-PEG2-acid
PROTAC Linkers
DBCO-PEG2-acid is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring a DBCO group, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for the development of targeted protein degradation strategies in chemical biology research. Its ability to form stable linkages enhances the design and application of bifunctional molecules for therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2304558-25-4 |
| Applications | PROTAC Linkers |
| Formula | C26H28N2O6 |
| Molecular Weight | 464.51 |
| SMILES | O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCC(NCCOCCOCCC(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.