Fig. 1 · Structure
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Azido-PEG5-PFP ester
PROTAC Linker
Azido-PEG5-PFP ester serves as a versatile PROTAC linker featuring a polyethylene glycol (PEG) moiety. Its primary mechanism involves facilitating targeted protein degradation via a biocompatible linker design. This compound is suitable for the synthesis of PROTACs, enabling efficient conjugation through click chemistry techniques, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules. Its application in research supports advancements in targeted therapeutics and protein modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1818294-48-2 |
| Applications | PROTAC Linker |
| Formula | C19H24F5N3O7 |
| Molecular Weight | 501.40 |
| SMILES | O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCOCCOCCOCCN=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.