Fig. 1 · Structure
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Azido-PEG2-C2-Boc
PROTAC Linker
Azido-PEG2-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. Its application in PROTAC development allows for the effective modification of target proteins, making it a valuable tool for chemical biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1271728-79-0 |
| Applications | PROTAC Linker |
| Formula | C11H21N3O4 |
| Molecular Weight | 259.30 |
| SMILES | O=C(OC(C)(C)C)CCOCCOCCN=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.