Fig. 1 · Structure
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Biotin-PEG4-TFP ester
PROTAC Linkers
Biotin-PEG4-TFP ester is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of proteins and enables targeted protein degradation through the recruitment of E3 ligases. Its application is pivotal in the development of innovative therapeutic strategies for selective modulation of protein levels in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2985664-57-9 |
| Applications | PROTAC Linkers |
| Formula | C27H37F4N3O8S |
| Molecular Weight | 639.66 |
| SMILES | O=C(NCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.