Fig. 1 · Structure
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m-PEG5-CH2CH2COOH
PROTAC Linker
m-PEG5-CH2CH2COOH is a polyethylene glycol (PEG) linker designed for use in PROTAC (PROteolysis TArgeting Chimera) synthesis. It facilitates the conjugation of ligands to E3 ligase recruiters, enhancing targeted protein degradation mechanisms. This reagent is crucial for the development of bifunctional molecules in drug discovery and research applications focused on modulating protein levels within cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1347750-72-4 |
| Applications | PROTAC Linker |
| Formula | C14H28O8 |
| Molecular Weight | 324.37 |
| SMILES | COCCOCCOCCOCCOCCOCCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.