Fig. 1 · Structure
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Bromoacetamido-PEG4-NHS ester
PROTAC Linker
Bromoacetamido-PEG4-NHS ester is a PEGylated linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its applications extend to chemical biology and drug discovery, where it aids in the development of innovative therapeutic strategies by modulating protein expression levels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1260139-70-5 |
| Applications | PROTAC Linker |
| Formula | C17H27BrN2O9 |
| Molecular Weight | 483.31 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCNC(CBr)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.