Biotin-PEG11-azide is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its biotinylated structure allows for high-affinity interactions with streptavidin or avidin, making it a valuable tool in chemical biology and proteomics applications.
Biotin-PEG11-azide is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its biotinylated structure allows for high-affinity interactions with streptavidin or avidin, making it a valuable tool in chemical biology and proteomics applications.
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