Catalog No.
Product Name
Application
Product Information
Citations
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HSD17B13 Inhibitor
HSD17B13-IN-56-d3 is a selective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of ≤ 0.1 μM for estradiol. This compound is valuable for investigating the role of HSD17B13 in liver diseases, metabolic disorders, and cardiovascular conditions, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and drug-induced liver injury (DILI). Its inhibitory action makes it a significant tool for exploring therapeutic strategies targeting these conditions. -
17β-HSD Inhibitor
HSD17B13-IN-36 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 of less than 0.1 μM for estradiol as a substrate. This compound is significant in the study of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH), making it valuable for research concerning metabolic disorders and liver health. Its selective inhibition of HSD17B13 may provide insights into therapeutic interventions for liver-related diseases. -
HSD17B13 Inhbitor
HSD17B13-IN-85 is a potent inhibitor of 17β-Hydroxysteroid dehydrogenase 13 (HSD17B13), exhibiting an IC50 of less than 0.1 μM for estradiol. This compound is primarily employed in the study of nonalcoholic fatty liver disease (NAFLD) and offers significant insights into the role of HSD17B13 in metabolic regulation and liver physiology. Its specific inhibition enhances understanding of the enzyme's contribution to various biological processes and potential therapeutic targets in liver-related disorders. -
FXR/HSD17B13 Modulator
FXR/HSD17B13 modulator 1 is a potent modulator targeting the farnesoid X receptor (FXR) and hydroxysteroid dehydrogenase 17 beta 13 (HSD17B13). This compound demonstrates significant biological activity relevant to the study of metabolic dysfunction-associated steatohepatitis (MASH). Its modulation of these targets can provide insights into therapeutic strategies for liver-related metabolic disorders. -
HSD17B13 Inhbitor
HSD17B13-IN-84 is a potent inhibitor of the enzyme 17β-Hydroxysteroid dehydrogenase type 13 (HSD17B13), demonstrating an IC50 of less than 0.1 μM for estradiol. This compound is primarily utilized in research concerning nonalcoholic fatty liver disease (NAFLD), providing valuable insights into the role of HSD17B13 in lipid metabolism and liver pathophysiology. Its effective inhibition of HSD17B13 supports studies aimed at understanding disease mechanisms and potential therapeutic interventions. -
HSD17B13 Inhibitor
HSD17B13-IN-98 is a potent inhibitor of 17 β-hydroxysteroid dehydrogenase (HSD17B13), demonstrating an IC50 value for estradiol of less than 0.1 μM. This compound is particularly relevant in the investigation of nonalcoholic fatty liver disease, providing valuable insights into the biochemical pathways involved in lipid metabolism and liver function. Its specificity and efficacy make it an essential tool for research focused on metabolic disorders and related therapeutic strategies. -
HSD17B13 Inhibitor
HSD17B13-IN-59 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of ≤ 0.1 μM for estradiol. This compound is valuable for research focused on liver diseases, metabolic disorders, and cardiovascular conditions, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and drug-induced liver injury (DILI). Its specific mechanism of action makes it an essential tool in elucidating the role of HSD17B13 in various pathophysiological contexts. -
17β-HSD1 Inhibitor
7-Coumaryl triflate is a selective inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), demonstrating an IC₅₀ of 360 nM and a Kᵢ of 173 nM. This compound selectively targets 17β-HSD2 while displaying no significant affinity for estrogen receptors ERα or ERβ. 7-Coumaryl triflate is valuable for research focused on hormone-dependent breast cancer and the modulation of estrogen metabolism. -
HSD17B13 Inhibitor
HSD17B13-IN-26 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). This compound exhibits significant activity in the modulation of steroid metabolism and demonstrates potential therapeutic applications in liver diseases, including hepatitis, liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. Researchers can utilize HSD17B13-IN-26 to further investigate the role of HSD17B13 in liver pathology and associated metabolic disorders. -
Anticancer Agent
Dehydrofalcarinol is a polyacetylene compound that targets 17β-hydroxysteroid dehydrogenase type 11, exhibiting notable anticancer activity. This compound has demonstrated potential in research applications focusing on triple-negative breast cancer, making it a valuable tool for investigating new therapeutic strategies in oncology. Dehydrofalcarinol's unique mechanism of action positions it as a promising candidate for further study in cancer biology. -
17β-HSD Inhibitor
4'-Hydroxyvalerophenone is a specific inhibitor of 17β-hydroxysteroid dehydrogenase (17β-HSD), exhibiting an IC50 value of 60.52 μM. This compound plays a significant role in steroid metabolism and can be utilized in various research applications related to hormonal regulation and steroid biosynthesis. Its inhibitory effects make it a valuable tool for studies investigating the role of 17β-HSD in physiological and pathological processes. -
17β-HSD5 Inhibitor
17β-HSD5 inhibitor 1 is a potent inhibitor of 17β-HSD5, demonstrating an IC50 of 2.9 nM in HEK-293 cells that overexpress human 17β-HSD5. This compound is primarily utilized in research applications related to steroid metabolism and is instrumental in studying the modulation of sex steroid biosynthesis. The selective inhibition of 17β-HSD5 can provide insights into its role in various hormonal disorders and therapeutic interventions. -
17β-HSD5 Inhibitor
17β-HSD5 inhibitor 2 is a potent inhibitor of 17β-hydroxysteroid dehydrogenase 5 (17β-HSD5), demonstrating an IC50 value of 40 nM. This compound is valuable for research into steroid metabolism and androgen biosynthesis, with potential applications in studying conditions related to hormone regulation and prostate cancer. Its inhibitory action enables the exploration of therapeutic strategies targeting 17β-HSD5 in various biological contexts. -
Herbicide
Chlorsulfuron is a selective herbicide that inhibits the enzyme acetolactate synthase, effectively blocking the biosynthesis of the amino acids valine and isoleucine in plants. This inhibition leads to the cessation of growth, making Chlorsulfuron a potent agent for controlling various weed species. It is primarily utilized in agricultural research to study plant physiology and herbicide resistance mechanisms. -
Herbicide
Pyrazosulfuron-ethyl is an herbicide that functions as an inhibitor of acetolactate synthase, a key enzyme in the biosynthetic pathway of branched-chain amino acids. This compound effectively controls a broad spectrum of weed species, making it valuable in agricultural applications, particularly in cereal, soybean, and vegetable crop production. Its selective action allows for effective weed management while minimizing harm to cultivated plants. -
Herbicide
Mesosulfuron-methyl is a sulfonylurea herbicide that targets acetolactate synthase (ALS). It exhibits effective post-emergence activity against various grass weeds, particularly ryegrass and wild oat species (Avena spp.), making it valuable in agricultural research focused on weed management in wheat cultivation. -
Herbicide
Cloransulam-methyl is a triazolopyrimidine sulfonanilide herbicide that functions primarily through the inhibition of acetolactate synthase (ALS). This compound effectively targets and controls broadleaf weeds in soybean crops. Its reliable herbicidal activity makes it a valuable tool for research focused on weed management and agricultural practices. -
Herbicide Safener
Herbicide Safener-2 is a herbicide safener that functions by competitively binding to the active site of acetolactate synthase (ALS), similar to mefenpyr-diethyl. This compound is designed to mitigate herbicide-induced injury in crops by enhancing their protection against herbicides such as mesosulfuron-methyl. Its pharmacokinetic profile allows for effective crop safeguarding during herbicide application, making it valuable for agricultural research and development. -
Herbicide
Triafamone is a sulfonamide herbicide that acts by inhibiting the enzyme acetolactate synthase (ALS). This inhibition disrupts the biosynthesis of branched-chain amino acids, leading to the effective control of various weed species. It is applicable in both pre-emergence and post-emergence scenarios in paddy fields, making it a valuable tool in agricultural weed management research. -
Sulfonylurea Herbicide
Prosulfuron is a fluorinated sulfonylurea herbicide that primarily targets acetolactate synthase (ALS), inhibiting the biosynthesis of branched-chain amino acids such as valine, leucine, and isoleucine in plants. This mechanism effectively suppresses the growth of certain weed species. Due to its low toxicity to humans and mammals, prosulfuron is utilized in research focused on broadleaf weed control in agricultural practices, particularly in maize and sweet corn. Additionally, it may influence the balance of soil microbial communities in alkaline conditions, highlighting its potential environmental impact. -
Herbicide
Pyrimisulfan is a selective inhibitor of acetolactate synthase (ALS) and functions as a broad-spectrum herbicide. It effectively targets a diverse array of paddy weeds, including annual grasses, sedges, and broadleaf species, as well as sulfonylurea-resistant biotypes, providing both pre- and post-emergence control. With its long residual activity and excellent safety profile for rice, Pyrimisulfan is valuable for research focusing on herbicidal mechanisms and paddy weed management strategies. -
Herbicide
Primisulfuron-methyl is a selective herbicide that targets the acetolactate synthase (ALS) enzyme, inhibiting its activity. This compound exhibits effective control of annual bluegrass in Kentucky bluegrass turf. Its specific mode of action makes Primisulfuron-methyl suitable for agricultural and research applications focused on turf management and weed control strategies. -
Herbicide
(E)-Pyriminobac-methyl is an acetolactate synthase inhibitor that functions as a pyrimidinylbenzoate herbicide. It effectively inhibits the biosynthesis of branched-chain amino acids, resulting in potent herbicidal activity. This compound has demonstrated efficacy against invasive species such as Echinochloa crus-galli and Leptochloa chinensis, with activity levels significantly surpassing those of certain other herbicides. Its application is essential for research focused on herbicide development and weed management strategies. -
Herbicide
Tritosulfuron is a sulfonylurea herbicide that targets acetolactate synthase, inhibiting its activity. This compound exhibits broad-spectrum efficacy as a post-emergent herbicide, specifically effective against dicotyledonous plants. It is commonly applied in the cultivation of cereals, maize, and turf to manage undesirable vegetation. -
CHI3L1 Inhibitor
CHI3L1-IN-1 is a selective inhibitor of Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, with an IC50 of 50 nM. This compound exhibits additional effects by inhibiting the hERG channel with an IC50 of 2.3 μM. CHI3L1-IN-1 is valuable for research applications focused on the roles of CHI3L1 in inflammation and cancer, offering insights into its potential as a biomarker and therapeutic target. -
Endogenous Metabolite
O-Nornuciferine is an aporphine-type alkaloid derived from lotus leaf that acts as a potent inhibitor of the hERG channel. This endogenous metabolite is significant in the study of cardiac ion channels and provides insights into drug-induced cardiac arrhythmias. Its biological activity makes it a valuable reagent in pharmacological research and safety assessments. -
CYP2D6 Inhibitor
Guanfu base A is a potent noncompetitive inhibitor of CYP2D6, with a Ki value of 1.20 μM in human liver microsomes and 0.37 μM for the recombinant form. This antiarrhythmic alkaloid, derived from Aconitum coreanum, also exhibits competitive inhibition of CYP2D in monkey and dog microsomes, with Ki values of 0.38 μM and 2.4 μM, respectively. In addition to its CYP2D6 inhibitory activity, Guanfu base A demonstrates the ability to inhibit HERG channel current, making it relevant for studies in drug metabolism and cardiac electrophysiology. -
Endogenous Metabolite
Minoxidil hydrochloride is an ATP-sensitive potassium (KATP) channel opener with significant vasodilatory properties. Its primary applications include use as a potent oral antihypertensive agent and in promoting hair growth. Additionally, Minoxidil hydrochloride exhibits inhibitory activity against soybean lipoxygenase, with an IC50 value of 20 μM, making it valuable for research in cardiovascular and dermatological studies. -
CYP2D6 Inhibitor
Guanfu base A hydrochloride is a selective inhibitor of the CYP2D6 enzyme, demonstrating significant potential in the management of arrhythmia-related disorders. This alkaloid exhibits inhibitory effects across various species, including humans, primates, and canines. Its ability to modulate CYP2D6 activity may provide valuable insights and therapeutic applications in pharmacology and toxicology research. -
Omeprazole Metabolite
4-Hydroxy omeprazole sulfide is a key metabolite of the proton pump inhibitor omeprazole, primarily involved in modifying gastric acid secretion. This compound serves as a valuable tool in pharmacokinetic and metabolic studies of omeprazole and its effects on gastric mucosa. Its biological activity is significant for understanding drug metabolism and potential drug interactions in gastrointestinal research. -
Endogenous Metabolite
NPD7155 is a purine-based competitive inhibitor of the enzyme MTH1, which plays a crucial role in the detoxification of oxidized purine metabolites. This compound demonstrates significant cytotoxic activity against cancer cells by promoting oxidative stress and disrupting metabolic pathways. NPD7155 is valuable for research into the mechanisms of cancer cell metabolism and the development of targeted cancer therapies. -
Endogenous Metabolite
Butaperazine dimaleate is an antipsychotic compound that serves as a reactive agent for the detection of vanadium (V). This reagent undergoes a reaction in phosphoric acid medium, resulting in the formation of a red radical cation that exhibits a maximum absorption at 513 nm. It follows Beer's law, applicable for concentrations ranging from 0.25 to 5.0 μg/ml, with a sensitivity of 6.1 ng/cm2. Butaperazine dimaleate is ideal for the analysis of vanadium in steel, minerals, biological samples, and soil. -
Endogenous Metabolite
8-(3-Chlorostyryl)caffeine is a selective antagonist of the A2a adenosine receptor, demonstrating a significant 520-fold selectivity in radioligand binding assays conducted in rat brain. It effectively inhibits adenylylase with a 22-fold selectivity in rat chromaffin cells. Co-administration with the A1-selective antagonist CPX has been shown to enhance exercise activity. Additionally, 8-(3-Chlorostyryl)caffeine exhibits potent inhibitory activity against MAO-B in primate mitochondrial systems. This compound serves as a valuable tool for studying adenosine receptor signaling and its effects on physiological processes. -
Endogenous Metabolite
Tetracosanoyl-sulfatide is an endogenous metabolite that serves as a significant molecular marker in various biological processes. Its primary role in the research of Mild Metachromatic Leukodystrophy allows for the investigation of lipid metabolism and myelin degradation. This metabolite is valuable for studying the pathophysiology of lysosomal storage disorders and for developing potential diagnostic tools and therapeutic strategies. -
Endogenous Metabolite
11-trans-Leukotriene C4 is a derivative of trans-Leukotriene C4 (LTC4) and functions as an important endogenous metabolite involved in inflammatory responses. It plays a crucial role in mediating allergic reactions and is implicated in various pathological conditions associated with inflammation. This compound is valuable for research related to inflammation, allergy, asthma, and other diseases where leukotrienes contribute to disease pathology. -
Endogenous Metabolite
Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is an endogenous metabolite of vitamin D3 with significant biological activity in bone health, cell differentiation, and immune function. As the active form of vitamin D, it is involved in regulating calcium and phosphate metabolism, thereby influencing various physiological processes. Calcitriol lactone is utilized in research to study vitamin D signaling pathways and their implications in bone disorders and immune responses. -
Endogenous Metabolite
N4-Acetylsulfamethazine is a metabolite of sulfamethazine, a widely utilized sulfonamide in veterinary medicine, specifically within the poultry farming sector. This compound serves as an endogenous metabolite, playing a role in the metabolic pathway of sulfonamides. It is relevant for research applications focusing on drug metabolism, residues in livestock, and the environmental impact of veterinary pharmaceuticals. -
Endogenous Metabolite
Metoprolol acid is an endogenous metabolite of the beta-blocker metoprolol. Although it does not exhibit pharmacological activity, it serves as a useful biomarker for studying the metabolism and pharmacokinetics of metoprolol in various biological samples. Researchers can detect metoprolol acid using solid phase extraction coupled with reversed phase high-performance liquid chromatography, employing fluorescence detection and specific eluents to ensure accurate analysis. -
Fungal Metabolite
Epicoccamide is a tetramic acid derivative that serves as a secondary metabolite derived from the fungus Epicoccum purpurascens. This compound exhibits antifungal properties, making it a valuable tool for researching fungal biology and exploring potential therapeutic applications in mycology. Its unique structure and biological activity offer insights into fungal metabolite functions and their interactions within ecological systems. -
Endogenous Metabolite
(S)-Higenamine, an endogenous metabolite and S-enantiomer of Higenamine, is a key precursor in the biosynthesis of benzylisoquinoline alkaloids. It is synthesized through the condensation of dopamine with 4-hydroxyphenylacetaldehyde via the enzyme norcoclaurine synthase. This compound plays a significant role in various biological activities, making it valuable for research in neurobiology and pharmacology. -
Endogenous Metabolite
STF-038533 is an inhibitor of the cAMP response element-binding protein (CREB), primarily targeting its transcriptional activity. This compound effectively suppresses the expression of CREB target genes, thereby modulating cellular signaling pathways. STF-038533 is invaluable for research into diseases associated with aberrant CREB activity, offering insights into therapeutic strategies for CREB-related disorders. -
Endogenous Metabolite
Pinoxepin hydrochloride is an antipsychotic compound primarily targeting neuropsychiatric conditions. It exhibits sedative and antidepressant properties, making it valuable in the study of mental disorders such as schizophrenia and depression. Additionally, Pinoxepin hydrochloride has been noted for its potential to enhance sleep quality, contributing to its utility in related research applications. -
Endogenous Metabolite
RI-61 is an endogenous metabolite that modulates neurotransmitter activity. This compound exhibits significant efficacy in alleviating symptoms associated with migraine, cluster headache, new daily persistent headache, and cyclical vomiting syndrome. Research applications include the study of pain mechanisms and therapeutic approaches for headache disorders. -
Endogenous Metabolite
Deleobuvir sodium is a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase, targeting viral replication. This compound exhibits significant anti-hepatitis C virus activity, making it a valuable tool for research into hepatitis C treatment. Its use facilitates the study of viral mechanisms and the development of therapeutic strategies aimed at combating hepatitis C infection. -
Endogenous Metabolite
11-trans Leukotriene E4 is an isomer of the endogenous metabolite Leukotriene E4 (LTE4) and functions primarily as a potent bronchoconstrictor. It exhibits equipotent activity to LTE4 in inducing contractions in guinea pig ileum. This compound is valuable for research into leukotriene pathways, inflammatory responses, and respiratory disorders. -
Fungal Metabolite
Neoechinulin C is a fungal metabolite belonging to the indolediketopiperazine alkaloid class. It exhibits protective effects on neuronal cells against paraquat-induced damage, making it a valuable compound for research related to neurodegenerative diseases such as Parkinson's disease. This compound is useful in studying mechanisms of cell protection and potential therapeutic strategies in neurobiology. -
Endogenous Metabolite
Bendiocarb is a carbamate compound that primarily acts as an inhibitor of the enzyme acetylcholinesterase. This inhibition results in increased levels of acetylcholine, which plays a crucial role in neurotransmission and muscle contraction. Bendiocarb is utilized in research applications focusing on neurobiology and the study of cholinergic systems, as well as in the examination of potential neurotoxic effects. -
Endogenous Metabolite
SKF 103784 is a vasopressin antagonist that targets the action of vasopressin, inhibiting its physiological effects linked to antidiuresis. This compound is valuable for investigating biological processes related to water and sodium homeostasis. Furthermore, SKF 103784 can be utilized in research to elucidate pathological mechanisms associated with cardiovascular diseases and endocrine disorders. -
Endogenous Metabolite
H-0106 dihydrochloride is a selective inhibitor of Rho-associated kinase (ROCK), primarily targeting the modulation of intraocular pressure (IOP). This compound exhibits significant IOP-lowering activity, as demonstrated in primate models. Research indicates that while H-0106 dihydrochloride effectively inhibits the ROCK enzyme, the relationship between ROCK inhibition and IOP reduction may not be straightforward, warranting further investigation into its mechanisms of action in ocular health. -
Endogenous Metabolite
3-(2-Aminopropyl)phenol is an endogenous metabolite known for its ability to elevate blood pressure. This compound has been shown to effectively alleviate symptoms of orthostatic hypotension in patients, significantly increasing blood pressure both at rest and upon standing after oral administration. Additionally, 3-(2-Aminopropyl)phenol may aid in mitigating pathological orthostatic adjustment disorders with minimal impact on heart rate and a favorable side effect profile. These properties make it a valuable tool for researching blood pressure regulation and related disorders.
