Catalog No.
Product Name
Application
Product Information
Citations
-
Fungal Metabolite
Berninamycin D is a cyclic peptide fungal metabolite that exhibits potent antifungal activity. Isolated from the fermentation of Streptomyces bernensis, this compound serves as an important tool in studying antifungal mechanisms and microbial interactions. It is applicable in various research settings focused on fungal pathogenesis and the development of new antifungal therapeutics. -
Endogenous Metabolite
(Rac)-Eflucimibe is an ACAT inhibitor that modulates endogenous hypercholesterolemia. It demonstrates significant potency and efficacy as an anti-hypercholesterol agent in various animal models of hypercholesterolemia. This compound is useful for investigating cholesterol metabolism and understanding the mechanisms of cholesterol regulation in biological systems. -
Endogenous Metabolite
Phenolic acid is an endogenous metabolite that plays a crucial role in various biochemical processes. Known for its antioxidant properties, it participates in the modulation of cellular signaling pathways and has implications in metabolic regulations. This compound is widely utilized in research exploring oxidative stress, inflammation, and metabolic disorders. -
Endogenous Metabolite
1,2-Dioleoyl-3-lauroyl-rac-glycerol is a triglyceride that serves as an endogenous metabolite, widely studied for its structural and distribution characteristics in various biological matrices. It has been identified in human milk, infant formula, and both mammalian and vegetable oils. This compound is useful in research focusing on lipid metabolism, nutrition, and the biochemical composition of milk fats. -
Endogenous Metabolite
DBPR110 is a potent inhibitor of nonstructural protein 5A (NS5A), specifically targeting hepatitis C virus (HCV) replication. It demonstrates significant antiviral activity with an EC50 of 3.9 ± 0.9 pM against HCV1b replicon reporter expression, and a selectivity index exceeding 12,800,000. Additionally, DBPR110 reduces HCV2a replicon activity with an EC50 of 228.8 pM and a selectivity index of over 173,130. This compound exhibits synergistic effects when used in combination with interferon alpha (IFN-α) and other antiviral agents, suggesting its potential as a viable small molecule therapeutic for HCV treatment. -
Endogenous Metabolite
FPL-55712 is a cysteine leukotriene type 1 receptor antagonist that exhibits anti-inflammatory effects. This compound effectively inhibits the biological responses induced by leukotrienes, thereby reducing allergic reactions and alleviating airway inflammation. FPL-55712 holds promise for research applications related to asthma and allergic rhinitis management. -
Endogenous Metabolite
AHR Activator 1 is an aryl hydrocarbon receptor (AHR) activator that modulates fibroblast growth factor-2 (FGF2)-induced branching morphogenesis. It functions by inhibiting AHR signaling, thereby preventing cellular branch formation. Additionally, AHR Activator 1 interacts with dissociated linkers, highlighting their significance in the inhibitory effects of AHR agonists on branching. This compound is valuable for studying mammary gland morphogenesis and understanding the mechanisms underlying FGF-induced invasion. -
Endogenous Metabolite
Muscarinic agonist 1 (AF267) targets muscarinic acetylcholine receptors, which are vital for cognitive function. This compound exhibits potential in alleviating cognitive impairments, making it a valuable tool for research into neurodegenerative diseases and cognitive disorders. Its mechanism of action provides insight into cholinergic signaling and its role in cognitive processes, thus serving as a significant reagent in neuroscience studies. -
Fungal Metabolite
Aspericin C is a pyran derivative derived from the marine fungus Rhizopus sp. 2-PDA-61. This compound exhibits cytotoxic effects against various cancer cell lines, including P388, A549, HL-60, and BEL-7420, with IC50 values of 14.6, 7.1, 61.4, and 24.2 μM, respectively. Aspericin C serves as a valuable tool for researching antitumor activity and the mechanisms underlying cytotoxicity in cancer biology. -
Endogenous Metabolite
YM471 free base is a selective non-peptide antagonist targeting vasopressin V1A and V2 receptors. It demonstrates high affinity for these receptors in rat models, with binding affinities (K values) of 0.16 nM for V1A and 0.77 nM for V2. This compound is valuable for investigating the role of vasopressin receptors in various physiological and pathological conditions. -
Endogenous Metabolite
(S)-CPP sodium is an inhibitor of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, also known as BDK. By negatively regulating BCKDC activity, (S)-CPP effectively activates the complex and significantly reduces plasma concentrations of branched-chain amino acids such as leucine, isoleucine, and valine in wild-type mice. This agent is useful for research applications investigating metabolic pathways and the regulation of amino acid levels in physiological and pathological contexts. -
Endogenous Metabolite
VB-201 is an oxidized phospholipid small molecule that functions as an anti-inflammatory agent. It inhibits innate cell activation mediated by CD14 and Toll-like receptor 2, thereby providing insight into inflammatory pathways. This compound is instrumental in studying the progression of atherosclerosis and serves as a valuable tool for research in cardiovascular diseases. -
Endogenous Metabolite
Neostigmine iodide is a reversible inhibitor of acetylcholinesterase, enhancing muscle tone and function. This compound is primarily utilized in the management of myasthenia gravis, aiming to improve muscle strength in affected patients. Additionally, Neostigmine iodide is employed in anesthetic procedures to counteract the effects of nondepolarizing muscle relaxants, such as rocuronium, thereby facilitating recovery from anesthesia. -
Endogenous Metabolite
Lifirafenib hydrochloride is a reversible inhibitor of the B-RAFV600E mutation, exhibiting significant antitumor activity in solid tumors, including melanoma, thyroid cancer, and low-grade serous ovarian cancer. This compound demonstrates selective cytotoxicity by preferentially targeting cancer cells harboring B-RAFV600E and EGFR mutations or amplifications. In preclinical studies, Lifirafenib has been shown to inhibit tumor growth in a dose-dependent manner, resulting in partial and complete tumor regression in animal models, making it a valuable tool for cancer research applications. -
Endogenous Metabolite
Complement factor I is a serine protease that serves to downregulate complement activity both in the fluid phase and on cell surfaces, primarily in association with cofactors such as factor H, complement receptor 1 (CR1/CD35), C4 binding protein (C4BP), or membrane cofactor protein (MCP/CD46). Its regulatory role is crucial in maintaining immune homeostasis and preventing tissue damage due to excessive complement activation. This enzyme is valuable in research applications focusing on immunology, autoimmune disorders, and the modulation of complement-mediated processes. -
Endogenous Metabolite
Chlorambucyl-proline is an amino acid derivative exhibiting inhibitory activity against bovine pulmonary vasoconstrictor enzyme. This compound functions as an irreversible inhibitor by forming ester bonds with the enzyme's aspartic or glutamic acid residues, leading to permanent enzyme inactivation. The rate of inactivation by chlorambucyl-proline is influenced by pH, with increased activity observed in the 5-8 range, making it a valuable tool for studying enzymatic regulation and function in physiological pH environments. -
Endogenous Metabolite
LY-79771 hydrochloride is a phenethanolamine compound that serves as an endogenous metabolite with antiobesity properties. It is primarily involved in inhibiting fat regain following energy deprivation, thereby aiding in weight management. This reagent is suitable for research applications focused on metabolic health and obesity-related studies. -
Endogenous Metabolite
Flurbiprofen sodium is a nonsteroidal anti-inflammatory drug (NSAID) targeting inflammatory pathways through the inhibition of carbonic anhydrase. It exhibits significant anti-inflammatory and analgesic properties, making it useful in the treatment of periodontal disease by reducing bone resorption. Additionally, Flurbiprofen sodium can be formulated into biodegradable microspheres for effective compound delivery, particularly within periodontal pockets, with the release kinetics influenced by the concentration of the polymer and polyvinyl alcohol used in its preparation. This compound is valuable for research into periodontal therapies and inflammation-related studies. -
Endogenous Metabolite
M-0002 hydrochloride is an antagonist of the vasopressin V2 receptor, acting as a key regulator of water balance and blood pressure. This compound is primarily investigated for its potential to inhibit ascites formation, making it relevant in research related to fluid retention disorders. Its favorable biological properties support further exploration in clinical applications. -
Endogenous Metabolite
Sermetacin (SH-G 318AB) is an endogenous metabolite with notable anti-inflammatory properties. This compound demonstrates strong biocompatibility, particularly in the RAW 264.7 mouse macrophage cell line, making it suitable for various biological applications. Sermetacin exhibits an anti-inflammatory response comparable to indomethacin, indicating its potential utility in research focused on inflammation pathways and therapeutic delivery mechanisms. -
Endogenous Metabolite
δ-CEHC is a metabolite of δ-tocopherol that acts primarily as an endogenous antioxidant. It demonstrates significant antioxidant activity, which may play a role in protecting cells from oxidative stress. δ-CEHC is utilized in research focused on investigating cellular responses to oxidative damage and exploring its potential therapeutic effects in various oxidative stress-related diseases. -
Endogenous Metabolite
Cyclo(Pro-Hyp) is a collagen-derived cyclic dipeptide that serves as an endogenous metabolite. Known for its role in promoting the proliferation of skin fibroblasts, Cyclo(Pro-Hyp) is crucial in tissue reconstruction processes. Its biological activity makes it a valuable reagent for research applications focusing on collagen metabolism and cellular regeneration in dermatological studies. -
Endogenous Metabolite
Cis-Vitamin K1 is an endogenous metabolite of Vitamin K that plays a critical role in the regulation of blood coagulation through its action as a cofactor for gamma-carboxylase. It promotes the post-translational modification of various proteins involved in hemostasis. This compound is utilized in research related to vitamin K biochemistry, coagulation studies, and the exploration of related metabolic pathways. Additionally, cis-Vitamin K1 may be investigated for its potential interactions in various physiological processes and disease states. -
Fungal Metabolite
Aspercolorin is a cyclic peptide fungal metabolite that exhibits significant antimicrobial properties. It has been studied for its potential use in inhibiting fungal growth, making it a valuable compound in antifungal research. Its unique structure and biological activity lend it to applications in investigating fungal metabolism and pathogenicity. -
Endogenous Metabolite
Pfn1-IN-2 is a selective inhibitor of Profilin1 (Pfn1), designed to disrupt the interaction between Pfn1 and actin filaments. This compound effectively decreases the levels of filamentous (F) actin within cells, leading to diminished migration and proliferation of endothelial cells. Pfn1-IN-2 demonstrates significant inhibition of endothelial cell angiogenic capabilities in both in vitro and in vivo research settings, making it a valuable tool for studies in angiogenesis and cellular dynamics. -
Fungal Metabolite
Carbolactone is a biologically active fungal metabolite known for its diverse biological activities. This compound exhibits antimicrobial properties, making it a valuable tool for research in mycology and natural product studies. Carbolactone's interaction with fungal systems can aid in the exploration of potential new antifungal agents and contribute to the understanding of fungal metabolism. -
Endogenous Metabolite
N-Succinyl-L-glutamate 5-semialdehyde is an endogenous metabolite involved in the glutamate metabolic pathway. It plays a significant role in the biosynthesis and metabolism of amino acids, particularly in the regulation of neurotransmitter levels. This compound is useful for research applications focused on metabolic processes, neurotransmission, and amino acid regulation. -
Endogenous Metabolite
VEC6 (NSC 11435) is an inhibitor of the VEZF1-DNA interaction, demonstrating significant activity in modulating vascular responses during ischemic retinopathy. It effectively reduces pathological angiogenesis while promoting lymphangiogenesis by influencing the expression of distinct gene sets in endothelial cells. VEC6 inhibits VEZF1-mediated transcriptional activity, thereby impacting endothelial cell proliferation and sprouting. This compound serves as a valuable tool for studying the molecular mechanisms of angiogenesis and lymphangiogenesis in various research applications. -
Endogenous Metabolite
MyomiRs-IN-1 is a specific inhibitor targeting endogenous metabolites involved in muscle cell differentiation. It effectively downregulates myoD protein translation in C2C12 cells without altering myoD mRNA levels, thereby affecting the expression of muscle differentiation markers. By modulating the regulatory pathway between miR-221/222 and myoD, MyomiRs-IN-1 is a valuable tool for researchers investigating muscle development and associated disorders. -
Endogenous Metabolite
A 62176 hydrochloride is a potent inhibitor of DNA topoisomerase II, demonstrating significant activity in disrupting purine synthesis in cancer cells. By interacting with G-quadruplex structures, A 62176 hydrochloride reduces c-MYC mRNA expression and displaces nucleosomes from the non-template strand of rDNA. This mechanism leads to DNA damage that necessitates repair via BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways, highlighting its potential applications in cancer research and therapeutic development. -
Endogenous Metabolite
L-Lysine orotate is a salt composed of L-lysine and orotic acid, functioning as an endogenous metabolite. This compound has been shown to potentiate the toxicity of extracts from the mushroom Amanita phalloides, making it relevant for studies investigating mycotoxin effects and metabolic pathways related to amino acids. Its unique interaction profile can be advantageous in research focused on toxicology and pharmacology. -
Endogenous Metabolite
(5R)-Dinoprost is an endogenous metabolite derived from the cyclooxygenase metabolism of arachidonic acid. As Prostaglandin F2β, it is known to induce a dose-dependent release of hexose-containing mucin. This compound is primarily utilized in research involving gastrointestinal physiology and reproductive biology, as well as studies exploring its roles in inflammation and smooth muscle contraction. -
Endogenous Metabolite
1a,1b-Dihomo prostaglandin F2α is a derivative of Prostaglandin F2α, acting as an endogenous metabolite. This compound plays a significant role in various biological processes, including inflammation and reproductive physiology. Its application in research is pivotal for studying prostaglandin pathways and their effects on cellular signaling and physiological functions. -
Endogenous Metabolite
1-(1Z-Octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine, also known as C18(Plasm)-22:6-PC, is an endogenous metabolite belonging to the phospholipid class. This compound exhibits significant variation in content and distribution across different fish species, making it a valuable biomarker for assessing species differentiation in ecological and nutritional studies. Its identification in fish viscera through lipidomics highlights its potential applications in marine biology and fishery science. -
Endogenous Metabolite
IRAK4-IN-29 is a selective inhibitor of the interleukin-1 receptor-associated kinase 4 (IRAK4), demonstrating low nanomolar activity. This compound effectively disrupts TLR-mediated signaling pathways and exhibits significant inhibition of cytokine production in response to LPS and R848 stimulation. In vivo studies reveal that IRAK4-IN-29 can suppress LPS-induced TNFα, mirroring the phenotype observed in IRAK4 gene-deficient mice. Furthermore, IRAK4-IN-29 possesses favorable medicinal chemistry characteristics, including microsomal stability and solubility, indicating its potential for clinical applications in inflammatory diseases. -
Endogenous Metabolite
Lu AF58801 is a selective positive allosteric modulator of the α7 nicotinic acetylcholine receptors, demonstrating potent oral bioavailability and effective brain penetration. This compound has been shown to enhance receptor activity and improve cognitive function in animal models, specifically in a novel object recognition task in mice subjected to subchronic exposure to fluchlorothiazol. Lu AF58801 serves as a valuable tool for investigating the role of α7 nicotinic receptors in cognitive processes and related disorders. -
Endogenous Metabolite
Aquacobalamin is a biologically active form of vitamin B12, primarily functioning as a cofactor in various enzymatic reactions. It enhances the oxidation of azo-dye Orange II in the presence of hydrogen persulfate, demonstrating its potential as a catalyst in oxidative reactions. Additionally, Aquacobalamin binds reversibly to hydrogen peroxide, forming a cobalt(III) hydroperoxo adduct with a dissociation constant of 0.25 mM, contributing to its diverse applications in biochemical research and oxidative stress studies. -
Endogenous Metabolite
Clinolamide is an N-cyclohexyl linoleamide that primarily targets endogenous metabolites. In studies assessing cholesterol metabolism in rats, a dietary dose of 0.3% over 21 days did not significantly alter serum, liver, or kidney cholesterol levels. However, it exhibited variable effects on cholesterol synthesis in liver slices depending on the specific substrates and concentrations used. This compound is relevant for research on lipid metabolism and cholesterol regulation. -
Endogenous Metabolite
Naftidrofuryl is an endogenous metabolite known for its capacity to enhance cellular oxidative capacity and exhibit antispasmodic activity. It is utilized primarily in the study of peripheral and cerebrovascular diseases, demonstrating efficacy in improving blood circulation. Research applications include investigating its potential therapeutic effects in conditions related to compromised vascular function. -
Fungal Metabolite
Setosusin is a fungal meroditerpenoid known for its unique spiro-fused 3(2H)-furanone structure. This compound exhibits significant biological activity, particularly as a potential antifungal agent. It serves as a valuable tool for research applications focused on fungal metabolism and the development of novel antifungal therapeutics. -
Endogenous Metabolite
H-Arg-Lys-OH is a dipeptide composed of L-arginine and L-lysine residues, serving as a significant endogenous metabolite. This compound exhibits key biological activities that may influence cellular signaling pathways and protein interactions. It is utilized in biochemical research to explore mechanisms involving peptide-mediated biological functions and to study the roles of specific amino acid sequences in various physiological processes. -
Endogenous Metabolite
T-2 Triol is an endogenous metabolite derived from the metabolism of T-2 toxin, characterized by reduced toxicity relative to its parent compound. This trichothecene mycotoxin is of interest in studies concerning its pharmacokinetics, particularly in broiler chickens, where it exhibits a half-life (t1/2λz) of 9.6 minutes, peak plasma concentration (Cmax) of 563 ng/ml, and a time to peak concentration (Tmax) of 2.5 minutes. T-2 Triol serves as a valuable reagent for investigating mycotoxin metabolite dynamics in agricultural and toxicological research. -
Endogenous Metabolite
1-Myristoyl-2-palmitoyl-3-butyryl-rac-glycerol is an endogenous metabolite classified as a triacylglycerol, consisting of myristic, palmitic, and butyric acid residues. It plays a significant role in lipid metabolism and is naturally present in human milk, contributing to the nutritional profile and health benefits associated with breastfeeding. This compound is valuable for research in metabolic disorders, lipoprotein function, and studies related to infant nutrition. -
Endogenous Metabolite
Phochinenin I is an endogenous metabolite sourced from the plant Pholidota chinensis. This natural compound exhibits notable biological activity, including potential antioxidant and anti-inflammatory properties. Researchers utilize Phochinenin I in studies related to metabolic processes and the exploration of plant-derived therapeutics. -
Endogenous Metabolite
6-Hydroxypyridin-2(1H)-one hydrochloride is an endogenous metabolite that plays a significant role in various biological processes. This compound is involved in regulating metal ion homeostasis and may influence cellular oxidative stress pathways. It is commonly used in research focused on neurochemistry, metalloprotein interactions, and the study of metabolic disorders. -
Endogenous Metabolite
MMV667492 is a potent inhibitor of the cytoskeletal protein Ezrin, effectively targeting its function in cellular processes. This compound demonstrates significant anti-invasion activity in osteosarcoma cells, hindering their metastatic potential. In addition to its in vitro efficacy, MMV667492 induces distinct morphological defects in zebrafish embryos, aligning with Ezrin inhibition mechanisms. Furthermore, it reduces lung metastasis in osteosarcoma models characterized by elevated Ezrin expression, making it a valuable tool for studying tumor biology and metastasis. -
Endogenous Metabolite
(S)-Mevalonic acid is an endogenous metabolite that serves as a crucial precursor in the mevalonate pathway, which is vital for cell growth and proliferation. It has been shown to effectively inhibit the decrease in viability induced by Simvastatin in C2C12 cells in vitro. This compound is valuable for research focused on conditions such as myopathy and heart failure, facilitating studies on metabolic disorders and potential therapeutic interventions. -
Endogenous Metabolite
PTC-510 Free Base is a selective inhibitor of hypoxia-induced VEGF expression in tumor cells. It effectively reduces endogenous VEGF production under hypoxic conditions, demonstrating significant activity in controlling tumor growth while minimizing associated toxicity. This compound offers a novel therapeutic approach to overcome the limitations of existing anti-VEGF therapies, making it a valuable tool for cancer research and therapeutic development. -
Endogenous Metabolite
Razobazam is a benzodiazepine derivative that primarily targets the central nervous system to enhance cognitive function. It has demonstrated significant effects on learning performance in socially deprived rat models, showing an 18% increase in avoidance scores post-training. Furthermore, Razobazam induces notable alterations in the optical density of specific brain regions, including a 22% reduction in the lateral habenula and a 25% increase in the ventral tegmental area, along with a 13% increase in the prefrontal cortex. This compound is valuable for research in neuropharmacology and cognitive enhancement. -
Drug Metabolite
Narcotoline is a phenylpyridine isoquinoline alkaloid that serves as a drug metabolite in the biosynthetic pathway of Noscapine. This compound is valuable for investigating the metabolic regulatory mechanisms associated with Noscapine, providing insights into its pharmacokinetics and biological activity. Researchers may utilize Narcotoline to explore the implications of Noscapine metabolism in various biological systems and applications.
