Catalog No.
Product Name
Application
Product Information
Citations
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DHFR Inhibitor
DHFR-IN-1 is a selective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 40.71 nM. This compound demonstrates significant antibacterial activity against both gram-positive and gram-negative bacteria, as well as moderate antifungal properties. Additionally, DHFR-IN-1 exhibits a strong synergistic effect when combined with Levofloxacin, characterized by a fractional inhibitory concentration index (FIC) value of 0.249, making it a valuable candidate for further research in antimicrobial applications. -
Endogenous Metabolite
Citaldoxime is an endogenous metabolite recognized for its role as a γ-radiation-induced antifungal stress metabolite found in Citrus plants. This compound exhibits notable antifungal activity, making it valuable for studies focused on plant stress responses and fungal pathogen interactions. Research applications include investigating metabolic responses to environmental stressors and exploring potential antifungal mechanisms in plant systems. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-2 is a quinazoline compound that functions as a dual inhibitor of CYP51 and PD-L1, exhibiting IC50 values of 0.263 μM and 0.017 μM, respectively. It displays notable antifungal activity by triggering early apoptosis in fungal cells, leading to significant reductions in intracellular IL-2, NLRP3, and NF-κBp65 protein levels. Additionally, CYP51/PD-L1-IN-2 induces mitochondrial damage and reactive oxygen species (ROS) accumulation, culminating in fungal lysis and subsequent cell death. This compound is valuable for research exploring antifungal mechanisms and cancer immunotherapy. -
VEGFR-2/DHFR Inhibitor
VEGFR-2/DHFR-IN-1 is a dual inhibitor of VEGFR-2 and dihydrofolate reductase (DHFR), exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. This compound demonstrates significant antibacterial activity against various strains, including Escherichia coli and MRSA, with MIC values ranging from 8 to 16 μg/mL. Additionally, VEGFR-2/DHFR-IN-1 shows potent cytotoxic effects on cancer cell lines C26, HepG2, and MCF7, with IC50 values between 2.97 and 7.12 μM. This reagent is applicable for research exploring cancer therapeutics and microbial resistance. -
C. albicans Nmt Inhibitor
SC-58272 is a potent and selective inhibitor of N-myristoyltransferase (Nmt) in Candida albicans, exhibiting an IC50 of 56 nM against the strain B311. This compound demonstrates a 250-fold selectivity for the fungal enzyme when compared to the human counterpart. SC-58272 is valuable for research applications involving fungal pathogenesis and the study of myristoylation processes in C. albicans. -
Succinate Dehydrogenase Inhibitor
Succinate dehydrogenase-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH). This indene amino acid derivative exhibits significant antifungal activity in vitro, with effective concentrations against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L). It is a valuable tool for research applications focused on inhibiting SDH in microbial pathogens. -
Fungal Metabolite
Viridiol is a fungal metabolite derived from Trichoderma viride, primarily exhibiting antifungal properties. This compound demonstrates efficacy against various fungal pathogens, making it a valuable tool for research into fungal biology and antifungal drug development. Its applications include investigating mechanisms of antifungal resistance and exploring potential therapeutic strategies for fungal infections. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-1 is a dual inhibitor targeting both CYP51 and PD-L1, exhibiting an IC50 of 0.884 μM for CYP51 and 0.083 μM for PD-L1. This quinazoline compound demonstrates notable antifungal activity by inducing early apoptosis in fungal cells while significantly reducing intracellular levels of IL-2, NLRP3, and NF-κBp65. Additionally, CYP51/PD-L1-IN-1 contributes to mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately leading to fungal lysis and cell death. This compound is valuable for research focused on antifungal therapies and immune modulation. -
Antifungal Metabolite
Eucalyptacid A is an antifungal metabolite that demonstrates significant antifungal activity against Alternaria solani, with minimum inhibitory concentration (MIC) values ranging from 6.25 to 50 μM. This compound is suitable for research applications focused on antifungal mechanisms and studying phytopathogen interactions. Its effectiveness positions it as a valuable tool for investigating potential antifungal treatments in agricultural and biomedical research. -
Succinate Dehydrogenase Inhibitor
SDH-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM in porcine SDH assays. This compound exhibits significant fungicidal activity, making it a valuable tool for investigating the role of SDH in fungal metabolism and potential therapeutic applications in fungal infections. Researchers may utilize SDH-IN-8 to explore mechanisms of SDH inhibition and its effects on cellular respiration and metabolic pathways. -
Antifungal Metabolite
Chaetosemin J is an antifungal metabolite with demonstrated inhibitory activity against several plant pathogenic fungi, including Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii. Its minimum inhibitory concentration (MIC) values range from 12.5 to 25 μM, indicating its potential utility in agricultural research and studies aimed at developing new antifungal agents. -
Antifungal Metabolite
Canadensolide is an antifungal metabolite derived from Penicillium canadense. It exhibits potent antifungal activity against various pathogenic fungi, making it valuable for studying fungal infections and developing antifungal strategies. Research applications include investigating mechanisms of action in fungal resistance and exploring potential therapeutic uses in clinical settings. -
Fungal Metabolite
dl-Aloesol is a natural fungal metabolite derived from Aspergillus species, primarily known for its diverse biological activities. It exhibits cytotoxic, antibacterial, anti-parasitic, antiviral, and antiproliferative properties, making it a valuable tool for research applications in microbiology, pharmacology, and medicinal chemistry. Its ability to scavenge free radicals further underscores its potential in studies focused on oxidative stress and cellular protection. -
CYP51 Inhibitor
CYP51-IN-19 is a potent inhibitor of cytochrome P450 51 (CYP51), a critical enzyme involved in sterol biosynthesis in fungi. This compound induces the generation of reactive oxygen species (ROS), leading to significant fungicidal activity. It is primarily utilized in antifungal research and the development of therapeutic agents targeting fungal infections. -
Carbonic Anhydrase Probe
(+)-Xylariamide A is a potent probe for carbonic anhydrases, specifically targeting the β-carbonic anhydrases found in mycobacterial and fungal pathogens. It demonstrates significant inhibitory activity, making it a valuable tool for studying the role of carbonic anhydrases in microbial physiology and pathogenicity. Research applications include investigating antifungal and antibacterial mechanisms, as well as exploring therapeutic strategies against resistant strains. -
Herbicide
Triclopyr is a foliar systemic herbicide primarily targeting broadleaf and woody plants. It disrupts plant growth by mimicking natural plant hormones, leading to uncontrolled growth and eventual plant death. This compound is essential in research applications focused on invasive species management and ecosystem restoration. Due to its potent biological activity, caution is advised when handling Triclopyr. -
Fungal Metabolite
Homogentisic acid lactone is a fungal metabolite that exhibits significant fungicidal activity, notably against the plant pathogenic fungus Fusarium graminearum. This compound is derived from the fungus WF5 and serves as a valuable substrate for assessing serum paraoxonase/arylesterase 1 (PON1) activity in biochemical research. Its unique mode of action and biological properties make it an important tool in studies related to fungal pathogenesis and enzyme activity assessment. -
Succinate Dehydrogenase Inhibitor
Isofetamid is a potent inhibitor of succinate dehydrogenase, primarily utilized as a fungicide. It demonstrates effective control against a range of fungal pathogens, including gray mold, white mold, and powdery mildew. This compound is valuable for research related to plant fungal diseases, contributing to the understanding of fungal inhibition mechanisms and disease management strategies. -
Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester hydrochloride is a dipeptide derivative that targets endogenous metabolites. It selectively induces apoptosis in lymphocytes with cytotoxic capabilities and can trigger stress in the endolysosomal pathway. This compound is valuable for research applications involving immune response modulation and the study of cellular stress mechanisms. -
Endogenous Metabolite
Betaine, also known as trimethylglycine, is an endogenous metabolite that functions primarily as a methyl donor, facilitating the maintenance of normal DNA methylation patterns. This compound is widely distributed in various food sources, including seafood, spinach, and wheat bran, and is recognized for its role as an osmolyte, helping to regulate cellular water and ion balance. In avian species, betaine enhances resilience to heat stress by preventing dehydration and osmotic inactivation, while also promoting beneficial microbial fermentation activity in the intestines under osmotic challenges. -
Endogenous Metabolite
3-Hydroxybutyric acid sodium is a sodium salt of an endogenous metabolite, primarily involved in energy metabolism and ketogenesis. Elevated levels of 3-Hydroxybutyric acid sodium are associated with type I diabetes and play a role in modulating membrane lipid properties, which can influence cellular functions. This compound is useful for research applications focused on metabolic diseases and the study of energy homeostasis. -
Endogenous Metabolite
Phenylacetylglutamine is an endogenous metabolite derived from the fermentation of amino acids by colonic microbiota. It plays a significant role in metabolic processes and can serve as an important biomarker in gastrointestinal research. This compound is utilized in studies examining microbial gut interactions and their influence on host metabolism. -
Endogenous Metabolite
(R)-3-Hydroxybutanoic acid sodium is an endogenous metabolite primarily acting as a source of energy and metabolic precursor. It is produced from acetoacetic acid through the enzymatic action of 3-hydroxybutyrate dehydrogenase. This compound plays a vital role in cellular metabolism, serving as a nutritional source and a precursor for the synthesis of various compounds, including vitamins, antibiotics, and pheromones, making it valuable for diverse biochemical research applications. -
Endogenous Metabolite
N-Lactoyl-Phenylalanine is an endogenous metabolite that functions as a signaling molecule, particularly induced through exercise. This compound exhibits biological activities that include the reduction of obesity and the enhancement of glucose tolerance. It offers potential applications in metabolic research and the study of exercise physiology. -
Endogenous Metabolite
Glycerol is an endogenous metabolite that serves as a key component in sample preparation and gel formation for polyacrylamide gel electrophoresis (PAGE). Its ability to stabilize proteins and nucleic acids makes it essential for effective separation and analysis in various biochemical studies. Glycerol is widely utilized in molecular biology and biochemistry laboratories to enhance the resolution and integrity of electrophoretic samples. -
Endogenous Metabolite
Sphingomyelin is an endogenous metabolite and a critical sphingolipid found predominantly in eukaryotic cell membranes, particularly within the myelin sheath enveloping neuronal axons. It is essential for various cellular processes, including the regulation of inflammatory responses and signal transduction pathways. Dysregulation of sphingomyelin metabolism has been implicated in several conditions, including central nervous system diseases and Niemann-Pick disease, making it a significant target for research in neurobiology and metabolic disorders. -
Endogenous Metabolite
Mevalonic acid lithium salt is a critical endogenous metabolite in the mevalonate pathway, vital for cellular growth and proliferation. This compound effectively counteracts the inhibitive effects of Simvastatin on C2C12 cell viability in vitro. Its applications extend to research in myopathy and heart failure, making it a valuable tool for studying related metabolic processes. -
Endogenous Metabolite
5-Hydroxyindole-3-acetic acid is the primary metabolite of serotonin, serving as an important endogenous biomarker. It is utilized in the assessment of neuroendocrine tumors, aiding in both diagnosis and monitoring of these malignancies. This compound plays a significant role in the study of serotonin metabolism and related pathophysiological conditions. -
Endogenous Metabolite
Mono-(2-ethylhexyl) phthalate (MEHP) serves as a significant endogenous metabolite of diethylhexyl phthalate (DEHP). MEHP is known to enhance fatty acid synthesis in hepatocytes through the modulation of gene and protein expression, thereby playing a critical role in the development of non-alcoholic fatty liver disease (NAFLD). This compound is valuable for research investigating metabolic disorders, liver function, and the impact of environmental phthalates on health. -
Endogenous Metabolite
Protocatechuic acid is a phenolic compound that acts as an endogenous metabolite. It demonstrates neuroprotective properties, making it valuable for research in neurobiology and the study of neurodegenerative diseases. Additionally, it may play a role in modulating oxidative stress and inflammation, thereby contributing to cellular protection. -
Endogenous Metabolite
Phosphorylethanolamine, an endogenous metabolite, serves as a crucial precursor for phosphatidylcholine and is integral to membrane phospholipid composition. Its presence in various animal tissues and human tumors underscores its role in maintaining membrane integrity, facilitating cell division, and supporting mitochondrial respiratory function. Alterations in phosphorylethanolamine levels have been linked to neurodegenerative diseases, including Alzheimer's and Parkinson's disease, as well as influencing insulin signaling in the liver. This compound is valuable for research in cancer, neurodegenerative disorders, and metabolic disease studies. -
Endogenous Metabolite
Indole-3-carboxaldehyde, an endogenous metabolite derived from the oxidative degradation of indole-3-acetic acid, serves as a valuable biochemical tool in research. This compound is utilized to synthesize analogs of the indole phytoalexin cyclobrassinin, contributing to studies on plant defense mechanisms. Additionally, Indole-3-carboxaldehyde has been shown to enhance the epithelial barrier and exhibit anti-inflammatory effects in the intestinal tract, making it relevant for research in gastrointestinal health and inflammation. -
Endogenous Metabolite
D-Fructose-6-phosphate disodium is an endogenous metabolite primarily involved in carbohydrate metabolism. It serves as an important intermediate in both the glycolytic pathway and the pentose phosphate pathway. This compound is useful for investigating the activities of glucosamine-6-phosphate synthase and transaldolase. Additionally, D-Fructose-6-phosphate disodium can be employed in studies related to Lewy body dementia, enhancing understanding of metabolic perturbations in this condition. -
Endogenous Metabolite
Glycoursodeoxycholic acid is an endogenous metabolite and a bile acid-glycine conjugate derived from ursodeoxycholic acid. This acyl glycine plays a significant role in bile acid metabolism and modulation of gut microbiota. Research applications include investigating its potential effects on liver function, metabolic disorders, and gastrointestinal health. -
Endogenous Metabolite
Riboflavin phosphate sodium, also known as flavin mononucleotide (FMN-Na), acts as an endogenous metabolite and is a derivative of riboflavin (vitamin B2), a vital nutrient for animals. This compound plays a significant role in NAD+ recycling and is utilized in research related to progressive keratoconus, corneal ectasia, and irregular astigmatism. Its biological activity makes it a valuable reagent for studies focused on visual health and metabolic processes. -
Endogenous Metabolite
DEHP (Bis(2-ethylhexyl) phthalate) primarily functions as an endogenous metabolite involved in the modulation of cellular processes. It exhibits a broad range of biological activities, including neurotoxic, hepatotoxic, immunotoxic, and reproductive toxic effects in various organisms. DEHP serves as a critical compound for research related to toxicology, environmental exposure studies, and the investigation of endocrine disruption mechanisms. -
Endogenous Metabolite
Lanosterol is an endogenous metabolite that plays a crucial role in cholesterol biosynthesis. It has been shown to induce the ubiquitination and degradation of HMG CoA reductase, a key regulatory enzyme in cholesterol synthesis. Additionally, lanosterol exhibits protective effects by suppressing the aggregation and cytotoxicity of misfolded proteins associated with neurodegenerative diseases. This compound is valuable for research applications focused on cholesterol metabolism and neurodegenerative processes. -
Endogenous Metabolite
DL-Isocitric acid trisodium salt is an endogenous metabolite that serves as an intermediate in the citric acid cycle. It is important for cellular respiration and energy production. This compound can be utilized as a biochemical marker for the analysis of isocitrate composition in fruit products, aiding in nutritional studies and quality assessments. -
Endogenous Metabolite
(R)-3-Hydroxybutanoic acid is an endogenous metabolite primarily formed from acetoacetic acid via the enzymatic action of 3-hydroxybutyrate dehydrogenase. This compound serves significant biological functions as an energy source and plays a critical role as a precursor for various biosynthetic pathways, including the production of vitamins, antibiotics, and pheromones. Its applications are valuable in metabolic studies and nutritional research. -
Endogenous Metabolite
Indole is a naturally occurring aromatic heterocyclic compound that acts as an endogenous metabolite in various biological systems. It plays a crucial role in bacterial physiology by mediating processes such as spore formation, plasmid stability, drug resistance, biofilm formation, and virulence through intercellular signaling. This compound is essential for research in microbial signaling and pathogenicity, making it valuable for studies in microbiology and infectious disease. -
Endogenous Metabolite
Nervonic acid is a monounsaturated fatty acid recognized for its role as an endogenous metabolite. This compound demonstrates anti-inflammatory activity primarily through the inhibition of NF-κB signaling pathways. Its properties make it a valuable tool for investigating neurodegenerative diseases and related pathologies. -
Endogenous Metabolite
Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is an endogenous polyunsaturated fatty acid predominantly found in the adrenal gland, brain, kidney, and vascular tissues. It plays a crucial role in regulating vascular tone in the arteries of the adrenal cortex. Additionally, Adrenic Acid has been implicated as an inflammation enhancer in non-alcoholic fatty liver disease, making it a valuable compound for research in vascular biology and metabolic disorders. -
Endogenous Metabolite
4-Hydroxyphenylacetic acid is an endogenous metabolite derived from polyphenols that exhibits antioxidative properties. This compound plays a significant role in cellular defense mechanisms by inducing the expression of Nrf2, a key regulator of antioxidant response. Its research applications include studying the effects of microbiota on metabolism and exploring therapeutic strategies for oxidative stress-related conditions. -
Endogenous Metabolite
Cinnamic acid is an endogenous metabolite known for its potential in cancer intervention. It exhibits significant cytotoxic effects with IC50 values ranging from 1 to 4.5 mM across various cancer cell lines, including glioblastoma, melanoma, prostate, and lung carcinoma. This compound serves as a valuable research tool for investigating cancer biology and therapeutic strategies. -
Endogenous Metabolite
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) is an endogenous metabolite and a bile acid known for its capacity to modulate bile acid synthesis. It effectively suppresses the production of endogenous bile acids and inhibits biliary cholesterol secretion. This compound is valuable for research applications related to cholesterol metabolism and bile acid signaling pathways. -
Endogenous Metabolite
Oleamide is an endogenous fatty acid amide that serves as a signaling molecule in the mammalian nervous system. It plays a role in various biological processes, including sleep regulation and inflammatory responses. Oleamide is utilized in research to investigate its effects on neurotransmission and neuroprotection, as well as its potential therapeutic applications in sleep disorders and neuroinflammation. -
Endogenous Metabolite
Isocitric acid is an endogenous metabolite that plays a crucial role in cellular metabolism, particularly within saliva and the cellular cytoplasm. This compound is significant for research into neurodegenerative diseases such as Alzheimer's disease and Lewy Body Dementia, as well as conditions related to anoxia. Its involvement in the tricarboxylic acid cycle makes it a valuable reagent for metabolic studies and related biochemical investigations. -
Endogenous Metabolite
Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid that primarily acts as an endogenous metabolite. It exhibits notable anti-inflammatory and anti-proliferative activities, making it relevant for research involving inflammation and cancer biology. DGLA has also been shown to attenuate atherosclerosis in apolipoprotein E deficient mouse models, providing a valuable tool for studying cardiovascular diseases and related metabolic disorders. -
Purine Nucleotide Biosynthesis Intermediate
SAICAR is a key intermediate in the de novo purine nucleotide biosynthesis pathway. It selectively activates the pyruvate kinase isoform M2 (PKM2) with an EC50 of 0.3 mM, enhancing the enzymatic activity. This compound is particularly relevant for research into cancer cell metabolism, as it promotes survival under glucose-limited conditions, making it a valuable tool in the investigation of tumor biology and metabolic regulation. -
Endogenous Metabolite
Adenosine 5′-diphosphoribose (ADP ribose) is an endogenous metabolite that plays a critical role in cellular signaling and regulation. It is primarily involved in the cellular response to DNA damage and the modulation of gene expression. ADP ribose serves as a substrate for poly(ADP-ribose) polymerases and is integral to various biological processes, including cell repair and apoptosis. This compound is valuable for research applications related to DNA damage response and chromatin remodeling.
