Catalog No.
Product Name
Application
Product Information
Citations
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PNMT Inhibitor
LY 78335 is a potent inhibitor of phenylethanolamine-N-methyltransferase (PNMT) with a Ki value of 0.09 μM. This compound also functions as an α₂-adrenoceptor antagonist, exhibiting an IC50 of 10 μM. Research indicates that LY 78335 enhances spontaneous locomotor activity in rat models and elevates the extracellular concentration of 3-methoxy-4-hydroxyphenylglycol (MHPG) in the hypothalamus. Additionally, it has been shown to inhibit growth hormone secretion, making LY 78335 a valuable tool for studies related to depression and neuroendocrine function. -
Endogenous Metabolite
1-Hydroxypyrene serves as a primary endogenous metabolite and biomarker for exposure to polycyclic aromatic hydrocarbons (PAHs), particularly pyrenes. This compound is analyzed in urine samples to assess environmental and occupational exposure. Additionally, 1-Hydroxypyrene acts as an orally active agonist of the aryl hydrocarbon receptor (AhR), which is implicated in various biological processes, including renal fibrosis. Its significance in toxicological studies makes it a valuable reagent for research applications. -
LOX Inhibitor
SNT-5382 is a potent lysyl oxidase (LOX) inhibitor, designed to disrupt the enzymatic activity of LOX, which plays a critical role in extracellular matrix remodeling. This compound demonstrates significant biological activity in inhibiting tumor progression and metastasis, making it a valuable tool for cancer research. SNT-5382 can be utilized in various studies aimed at understanding the implications of LOX in malignancies and assessing potential therapeutic strategies. -
11β-HSD1 Inhibitor
11β-HSD1-IN-25 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This compound effectively reduces glucocorticoid levels both in vitro and in serum, while also diminishing lipid accumulation in various models. It modulates lipid metabolism through dual mechanisms involving the inhibition of 11β-HSD1 and activation of the AMP-activated protein kinase (AMPK) signaling pathway. 11β-HSD1-IN-25 is suitable for research applications focused on obesity and related metabolic disorders. -
DHFR Inhibitor
NSC309401 dihydrochloride is a selective inhibitor of dihydrofolate reductase (DHFR) from Escherichia coli, exhibiting an IC50 of 189 nM and a KD of 14.57 nM. This compound is primarily utilized in studies focused on microbial metabolism and antibiotic resistance. Its potent inhibition of DHFR makes it a valuable tool in researching folate biosynthesis pathways and developing novel therapeutic agents. -
Factor Xa Inhibitor
ChloraMine-T hydrate is a selective Factor Xa inhibitor known for its utility in synthetic chemistry. It serves as a versatile reagent in aminohydroxylation and allylic amination reactions, functioning as a nitrogen source in the aziridination of alkenes and facilitating the deprotection of sulfur groups in thiol-containing compounds. Additionally, ChloraMine-T hydrate exhibits antimicrobial properties, demonstrating efficacy against various bacterial strains, including Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and Enterococcus cloacae, making it valuable for applications in both enzymatic inhibition studies and antimicrobial research. -
DGAT Inhibitor
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone is a diacylglycerol acyltransferase (DGAT) inhibitor, demonstrating an IC50 of 20.1 μM. Additionally, it acts as an angiotensin II receptor blocker with an IC50 of 34.1 μM. This compound exhibits significant anti-Helicobacter pylori activity, with a minimum inhibitory concentration (MIC) of 10 μg/mL, making it valuable for studies investigating lipid metabolism and bacterial infections. -
Fungal Metabolite
BE 24566B is a polyketide fungal metabolite that acts as an endothelin receptor antagonist, targeting both ETA and ETB receptors with IC50 values of 11 μM and 3.9 μM, respectively. This compound demonstrates antibacterial activity against a range of Gram-positive bacteria, including B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus, with reported MICs of 1.56 μg/mL for five of these species and 3.13 μg/mL for E. faecalis and S. thermophilus. BE 24566B is valuable for research applications in antimicrobial studies and receptor pharmacology. -
Cholecystokinin Receptor Antagonist
A-65186 is a cholecystokinin (CCK) A receptor antagonist that effectively inhibits CCK8-induced amylase secretion. This compound exhibits high binding affinity for pancreatic CCK-A receptors and demonstrates over 500-fold selectivity for CCK-A over CCK-B receptors. It serves as a valuable tool in research focused on gastrointestinal physiology and the role of CCK signaling in pancreatic function. -
CCK-A Receptor Agonist
A71378 is a selective CCK-A receptor agonist with an IC50 of 0.4 nM for the pancreatic CCK-A receptor, and significantly higher IC50 values for the cortical CCK-B and gastrin receptors at 300 nM and 1,200 nM, respectively. This compound effectively stimulates pancreatic amylase secretion with an EC50 of 0.16 nM and induces ileal muscle contraction with an EC50 of 3.7 nM. A71378 is valuable for research applications focusing on gastrointestinal pharmacology and the role of CCK-A receptors in digestive processes. -
CCK-4 Analog
A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (CCK-4), acting as an agonist for pancreatic amylase release. It also serves as a partial agonist, promoting phosphoinositide decomposition in pancreatic cells. With an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor, A-70874 shows a notable affinity of 1.6 μM for the CCK-B/gastrin receptor. This compound is valuable for investigating the physiological roles of CCK receptors in both the digestive system and the central nervous system. -
Phospholipase D Inhibitor
Halopemide is a potent inhibitor of phospholipase D (PLD), exhibiting IC50 values of 220 nM for human PLD1 and 310 nM for PLD2. In addition to its enzymatic inhibition, Halopemide functions as a dopamine receptor antagonist and exhibits psychotropic properties. This reagent is valuable for research applications exploring PLD-mediated signaling pathways and dopamine receptor interactions in various biological contexts. -
DPPH Scavenger
Epicoccone B is a potent DPPH radical scavenger, exhibiting an IC50 value of 10.8 μM, indicating its effectiveness in neutralizing free radicals. This compound, isolated from C. globosum, also demonstrates significant α-glucosidase inhibition with an IC50 value of 27.3 μM. Additionally, Epicoccone B has been noted for its anti-HIV activity, making it a valuable reagent for oxidative stress studies and diabetes research. -
CYP3A Inhibitor
Cobicistat-d8 is a deuterated analog of Cobicistat, acting as a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC50 values ranging from 30 to 285 nM. This reagent functions primarily as a pharmacokinetic enhancer, improving the absorption and bioavailability of anti-HIV agents. Its role in modulating drug metabolism makes it a valuable tool in pharmaceutical research and drug development. -
α-Glucosidase/HMG-CoA reductase Dual Inhibitor
Ganomycin I is a dual inhibitor targeting α-Glucosidase and HMG-CoA reductase. It demonstrates significant anti-diabetic properties and inhibits HIV protease, contributing to its potential as an antiviral agent. Additionally, Ganomycin I shows effectiveness in preventing osteoclastogenesis, making it a valuable reagent for research in diabetes and bone metabolism. -
Herbicide
Altenuisol is a herbicidal compound derived from the pathogenic fungus of the genus Alternaria in Xanthium italicum. It demonstrates notable biological activity by promoting root growth in Pennisetum alopecuroides and Medicago sativa at low concentrations while inhibiting their growth at higher doses. Additionally, Altenuisol exhibits cytotoxic effects on HeLa cells and possesses antibacterial and antioxidant properties. This compound is anticipated to facilitate research in agricultural weed management, cancer biology, and antimicrobial studies. -
α-Glucosidase I Inhibitor
Celgosivir hydrochloride is an α-glucosidase I inhibitor that demonstrates significant antiviral activity by inhibiting bovine viral diarrhoea virus (BVDV) with an IC50 value of 1.27 μM in in vitro assays. This compound is valuable for researchers studying viral infections and exploring potential therapeutic strategies through glycosidase inhibition. Its ability to modulate glycosylation processes makes it a relevant tool for biochemical and pharmacological investigations. -
ER α-glucosidases I/II Inhihitor
IHVR-19029 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting an IC50 of 0.48 μM for α-glucosidase I. This compound demonstrates significant antiviral activity by effectively blocking the replication of various hemorrhagic fever viruses, including Dengue virus (DENV), Ebola virus (EBOV), and Rift Valley fever virus. Research applications include the exploration of antiviral strategies, especially in combination therapies, such as enhancing the efficacy of Favipiravir. -
Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
Glucosidase Inhibitor
Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies. -
Anti-oxidant, Lipid Peroxidation/5-lipoxygenase Inhibitor
LY221068 is a potent inhibitor of iron-dependent lipid peroxidation and 5-lipoxygenase, exhibiting notable antioxidant properties. This compound demonstrates significant anti-inflammatory activity, particularly in preclinical models of arthritis, such as the Freund's Complete Adjuvant-induced arthritis model in rats, where it effectively reduces bone damage and paw swelling. LY221068 serves as a valuable tool for investigating inflammatory processes and potential therapeutic approaches in arthritis research. -
MAO-A Inhibitor
Pirlindole mesylate is a selective and reversible inhibitor of monoamine oxidase A (MAO-A), playing a crucial role in the modulation of neurotransmitter metabolism. Additionally, Pirlindole exhibits antiviral activity against enterovirus D68 and coxsackievirus B3 (CV-B3), positioning it as a potential agent in virology research. This compound is valuable for studies focusing on depression, anxiety disorders, and the therapeutic mechanisms of neuronal regulation and viral infections. -
FXR Agonist
Vonafexor is a selective agonist of the farnesoid X receptor (FXR), offering an oral bioavailability profile. This compound has demonstrated substantial reductions in HBsAg levels when used in conjunction with Peg-IFNα. Vonafexor is primarily employed in anti-HBV research, making it a valuable reagent for studies focused on hepatitis B virus therapies. -
Herbicide
Cyprosulfamide is a herbicide that targets salinity stress in plants, enhancing their growth and resilience. It promotes vigorous development, including the formation of new tillers and early flowering, making it a valuable tool in agricultural research aimed at improving crop tolerance to unfavorable environmental conditions. This compound is useful for studies focused on plant physiology and stress response mechanisms. -
PDE4B/D Inhibitor
PDE4B/D-IN-5 is a potent inhibitor of phosphodiesterase 4B and 4D, displaying IC50 values of 3.4 nM and 2.2 nM, respectively, with limited central nervous system penetration. This compound effectively inhibits TNF-α production and demonstrates significant anti-inflammatory, antioxidant, and anti-apoptotic properties by reducing the Bax/Bcl2 ratio and mitigating oxidative stress through decreased myeloperoxidase activity and nitric oxide levels. PDE4B/D-IN-5 is suitable for research applications in acute lung injury and related inflammatory conditions. -
Endogenous Metabolite
Hexadecanedioic acid, also known as Thapsic acid, is an endogenous metabolite that plays a crucial role in cellular metabolism. It inhibits IRE1α-mediated XBP1 splicing, thereby affecting flipogenesis and ferroptosis. Additionally, Hexadecanedioic acid downregulates the expression of XBP1 and Hrd1 while activating the Nrf2/SLC7A11/GPX4 pathway. This compound is valuable for research into metabolic-associated fatty liver disease and related metabolic disorders. -
MAO-B Inhibitor
Monoamine Oxidase B Inhibitor 6 is a highly selective, reversible, and competitive inhibitor of monoamine oxidase B (MAO-B) with a significant brain-blood barrier penetration capability, exhibiting an IC50 of 0.11 μM. This compound demonstrates notable antioxidant and neuroprotective properties and is applicable in the study of neurodegenerative diseases. Researchers investigating the role of MAO-B in neurobiology may find it a valuable tool for elucidating mechanisms of disease and exploring therapeutic avenues. -
CYP3A Inhibitor
ALT-2074 is a CYP3A inhibitor with an IC50 value ranging from 2.0 to 2.6 μM, functioning as a catalytic analogue of glutathione peroxidase. Although it demonstrates a weak inhibitory effect on CYP3A in vivo, it serves as a valuable tool for studying the role of oxidative stress in inflammatory diseases, including acute coronary syndrome. This compound is particularly useful in research investigating the interplay between reactive oxygen species and metabolic pathways. -
ALDH1A Inhibitor
ALDH1A Inhibitor 673A is a selective inhibitor targeting ALDH1A1, ALDH1A2, and ALDH1A3, with IC50 values of 246 nM, 230 nM, and 348 nM, respectively. This compound demonstrates minimal inhibitory effects on other ALDH family members. It has been shown to induce necroptotic death in ovarian cancer stem-like cells and cause DNA double strand breaks in cancer cells. ALDH1A Inhibitor 673A serves as a valuable tool for researching ovarian cancer mechanisms and treatment strategies. -
Necroptosis/11β-HSD1 Inhibitor
Necroptosis-IN-3 is a selective inhibitor of necroptosis, primarily targeting TNF-α induced necroptotic pathways. Additionally, this compound inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby modulating glucocorticoid metabolism. Its key biological activities make it a valuable tool for researchers studying necroptosis and related cellular mechanisms in various disease models. -
Herbicide/Microtubule inhibitor
Ethalfluralin is a dinitroaniline herbicide that functions as a microtubule inhibitor. By disrupting intranuclear spindle formation, Ethalfluralin effectively obstructs nuclear division and cytokinesis in parasites. This compound also enhances phosphorylation of NF-κB and P38 MAPK while inhibiting the PI3K/AKT signaling pathway, leading to impaired mitochondrial functionality, apoptosis, endoplasmic reticulum stress, autophagy, and increased reactive oxygen species (ROS) production. Ethalfluralin is particularly relevant for research applications in toxoplasmosis and related parasitic diseases. -
Herbicide
Antimalarial agent 17 is a potent photosystem II inhibitor with dual functionality as both an antimalarial agent and a herbicide. This compound demonstrates effective post-emergence herbicidal activity, comparable to that of leading commercial herbicides. It can be utilized in agricultural research to study herbicide resistance mechanisms and in the development of novel herbicidal agents. -
Fungal Metabolite
Asterriquinol D dimethyl ether is a fungal metabolite that acts as an inhibitor of cell proliferation in mouse myeloma NS-1 cell lines, exhibiting an IC50 of 28 µg/mL. Additionally, it demonstrates inhibitory effects on Tritrichomonas foetus. This compound is valuable for research applications in studying fungal metabolism and evaluating potential therapeutic agents against specific cell types and pathogens. -
DGAT-1 Inhibitor
Aphadilactone C is a selective inhibitor of diacylglycerol O-acyltransferase 1 (DGAT-1), exhibiting an IC50 of 0.46 μM. In addition to its DGAT-1 inhibition, Aphadilactone C demonstrates notable antimalarial properties with an IC50 value of 170 nM. This compound is valuable for research related to lipid metabolism and malaria treatment studies. -
PDEB1 Inhibitor
PDEB1-IN-1 is a selective inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibiting an IC50 value of 0.95 μM. This compound effectively inhibits the proliferation of T. brucei, with an EC50 of 26 μM, making it a valuable tool for research in trypanosomiasis. PDEB1-IN-1 can be utilized in studies aimed at understanding the role of PDEB1 in the pathogenesis of the disease and for exploring therapeutic avenues in antiparasitic drug development. -
CYP51 Inhibitor
VNI is a potent inhibitor of cytochrome P450 51 (CYP51), targeting sterol synthesis in the parasite Trypanosoma cruzi. Its mechanism of action disrupts the biosynthesis of essential sterols, leading to impaired growth and viability of the pathogen. VNI is primarily utilized in research focused on anti-parasitic strategies and the development of therapeutics for Chagas disease. -
CYP51 Inhibitor
CYP51-IN-15 is a selective inhibitor of CYP51, targeting the enzyme in Naegleria fowleri. With an EC50 value of 1.5 μM, it demonstrates potent biological activity against this pathogenic organism. This compound is valuable in research aimed at elucidating mechanisms of action and developing therapeutic strategies against Naegleria fowleri infections. -
Insect Pheromone
(Z)-7-Hexadecenal is an insect pheromone that plays a crucial role in the attraction of male insects. This compound has been isolated from female Heliothis virescens moths and is pivotal for understanding insect communication and behavior. It is commonly employed in research applications related to pest control strategies and the study of insect olfactory systems. -
CYP51 Inhibitor
LP8 is a pyridinyl-type inhibitor of cytochrome P450 51 (CYP51), specifically targeting the sterol biosynthesis pathway in various pathogens. This compound exhibits significant biological activity against Trypanosoma cruzi, the causative agent of Chagas disease and American trypanosomiasis. LP8 is valuable for research applications aimed at elucidating the mechanisms of these diseases and developing potential therapeutic strategies. -
Dinitroaniline Herbicide
Nitralin is a dinitroaniline herbicide that functions by disrupting microtubule polymerization, thereby inhibiting cell division in target organisms. This compound demonstrates significant inhibitory activity against Cryptosporidium parvum, with an IC50 of 4.5 µM. Nitralin is primarily utilized in research focused on herbicidal action mechanisms and the control of protozoal infections. -
Fungal Metabolite
Lachnumon is a fungal metabolite known for its nematicidal and antimicrobial properties. This compound exhibits significant biological activity against nematodes and various microbial strains, making it a valuable tool for research in agricultural and pharmaceutical applications. Its unique mechanism of action offers potential insights into pest management and the development of antimicrobial agents. -
Pv NMT Inhibitor
NMT-IN-3 is a selective inhibitor of N-myristoyltransferase (NMT) targeting Plasmodium vivax. With an IC50 of 38 mM, it demonstrates significant inhibitory activity against Pv NMT. This reagent is valuable for studying myristoylation processes in malaria research and evaluating potential therapeutic strategies against Plasmodium infections. -
Phenol
2-Methylcardol triene is a phenolic compound that exhibits potent α-glucosidase inhibition with an IC50 of 39.6 μM. Notably, this compound demonstrates schistosomicidal activity, effectively eliminating 100% of adult Schistosoma mansoni worms within 24 hours at concentrations of 100 and 200 μM. Additionally, 2-Methylcardol triene serves as a valuable precursor for synthesizing mono- and bis-benzoxazines, making it a versatile reagent for various chemical and biological research applications. -
Folic Acid/DHFR Antagonist
Aminopterin sodium is a folic acid antagonist that primarily targets dihydrofolate reductase (DHFR). By inhibiting DHFR, it disrupts folate metabolism, leading to decreased nucleic acid synthesis. This compound is primarily utilized in the treatment of acute lymphoblastic leukemia and various cancers. Additionally, Aminopterin sodium is employed as an immunosuppressant for the management of autoimmune disorders. -
DHFR Inhibitor
Lysine-methotrexate is a dihydrofolate reductase (DHFR) inhibitor, structurally related to Methotrexate. This compound exhibits potent biological activity by inhibiting folate metabolism, making it useful in studying cellular processes that rely on nucleotide synthesis. Lysine-methotrexate is applicable in cancer research and other therapeutic contexts where modulation of DHFR activity is of interest. -
MtDHFR Inhibitor
DHFR-IN-2 is a potent uncompetitive inhibitor of MtDHFR (dihydrofolate reductase from Mycobacterium tuberculosis), demonstrating an IC50 value of 7 μM. This compound serves as a valuable tool for tuberculosis research, aiding in the study of pathogenic processes and potential therapeutic strategies against TB. -
DHFR Inhibitor
Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an established antifolate agent. This compound functions as an antimetabolite, exhibiting cytotoxic effects on rapidly dividing cells, making it relevant for cancer research. Its ability to inhibit DHFR provides a valuable tool for investigating folate metabolism and developing therapeutic strategies against various malignancies. -
DHFR Inhibitor
TNP-351 is a dihydrofolate reductase (DHFR) inhibitor known for its potent antitumor activity. This antifolate compound exhibits efficacy against both leukemia and solid tumor cells in vitro and in vivo, making it a valuable tool in cancer research. Its mechanism of action involves the disruption of folate metabolism, ultimately hindering DNA synthesis and cell proliferation. -
SCDKI Pathway Inhibitor
SNX7 is a selective inhibitor of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. This compound plays a crucial role in studying cellular senescence and various CDKI-related diseases. By targeting the CDKI pathway, SNX7 serves as a valuable tool in cancer research and other conditions where cell cycle regulation is disrupted.
