SAICAR is a key intermediate in the de novo purine nucleotide biosynthesis pathway. It selectively activates the pyruvate kinase isoform M2 (PKM2) with an EC50 of 0.3 mM, enhancing the enzymatic activity. This compound is particularly relevant for research into cancer cell metabolism, as it promotes survival under glucose-limited conditions, making it a valuable tool in the investigation of tumor biology and metabolic regulation.
SAICAR is a key intermediate in the de novo purine nucleotide biosynthesis pathway. It selectively activates the pyruvate kinase isoform M2 (PKM2) with an EC50 of 0.3 mM, enhancing the enzymatic activity. This compound is particularly relevant for research into cancer cell metabolism, as it promotes survival under glucose-limited conditions, making it a valuable tool in the investigation of tumor biology and metabolic regulation.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
