Catalog No.
Product Name
Application
Product Information
Citations
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GAL2R Agonist
Galanin (2-29) (rat) is a selective GAL2R agonist with a Ki of 3.5 nM, exhibiting significant biological activity in modulating peptide secretion. This peptide has been shown to inhibit rat pancreatic protein and CCK-8-stimulated amylase secretion, making it a valuable tool for research on pancreatic function and gastrointestinal regulation. Applications include studies on neuroendocrine signaling and the investigation of galanin receptor pathways. -
Endogenous Metabolite
Kinetensin is an endogenous peptide that exhibits neurotensin-like properties. It has been isolated from pepsin-treated human plasma and functions as a neuromodulator, influencing various biological processes such as pain perception, neuroinflammation, and gastrointestinal functions. Kinetensin is utilized in research applications aimed at understanding neuropeptide signaling pathways and their implications in various physiological and pathological conditions. -
Sex Pheromone
(E)-8-Dodecenyl acetate is a sex pheromone that targets the olfactory receptors of male Gymnandrosoma aurantianum moths, acting as an agonist. This compound plays a significant role in the study of insect communication and behavior, making it valuable for research focused on agricultural pest management. Its unique mechanism offers potential insights into pest control strategies and the ecological impact of pheromones. -
Endogenous Metabolite
[Leu5]-Enkephalin TFA is a pentapeptide that functions as an agonist at opioid receptors. This endogenous metabolite exhibits morphine-like properties, playing a significant role in pain modulation and analgesic pathways. Its biological activity makes it valuable in research focused on opioid signaling and the development of pain management therapies. -
GPCR19 Agonist /FXR Antagonist
Ursodeoxycholic acid sodium is a potent agonist of the G-protein coupled receptor 19 (GPCR19) and antagonist of the farnesoid X receptor (FXR). This secondary bile acid plays a crucial role in maintaining intestinal barrier integrity and regulating lipid metabolism. Its ability to modulate bile acid-activated receptors makes it valuable for investigating various hepatic and gastrointestinal diseases. Ursodeoxycholic acid sodium is also orally active, making it suitable for diverse in vitro and in vivo research applications. -
Free Radical Scavenger
Cirsiliol 4′-glucoside is a free radical scavenger derived from Ruellia tuberosa L. This compound exhibits significant antioxidant properties, contributing to its potential anti-diabetic activity. Its ability to modulate oxidative stress makes it a valuable reagent for research in diabetes and related metabolic disorders. -
Tibolone Metabolite
3a-Hydroxytibolone is a metabolite of Tibolone, primarily targeting estrogen receptors. This compound exhibits significant biological activity relevant to breast cancer research, providing insights into hormone-related tumor proliferation. Its application extends to studies on the hormonal modulation of breast tissue and the development of therapeutic strategies for hormone-sensitive cancers. -
Active Metabolite
Dabigatran acyl-β-D-glucuronide is an active metabolite of the direct thrombin inhibitor Dabigatran. This compound enhances activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma, reflecting its anticoagulant properties. It is valuable for studying the pharmacokinetics and pharmacodynamics of anticoagulants in various research applications. -
Quinidine Metabolite
3-Hydroxyquinine is a metabolite of Quinidine, primarily targeting cardiac arrhythmias. It has been shown to prevent ventricular fibrillation and ventricular tachycardia in an isolated rat heart model after coronary reperfusion, demonstrating concentration-dependent effects. This compound is valuable for research focusing on cardiac pathophysiology and the mechanistic study of arrhythmias. -
Drug Metabolite
Ichangin is a drug metabolite derived from the ponderosa lemon (Citrus pyriformis) that exhibits significant antioxidant and anti-inflammatory properties. This compound is of interest in biochemical research for its potential therapeutic applications in oxidative stress-related disorders and inflammation. Its ability to modulate biological pathways makes Ichangin a valuable tool for investigating the effects of natural products in drug metabolism and pharmacology. -
Metabolite of Mosapride
Mosapride N-Oxide is a significant active metabolite of Mosapride, a gastroprokinetic agent that selectively targets the 5HT4 receptor. This compound plays a crucial role in enhancing gastrointestinal motility and is utilized in research exploring gastrointestinal disorders and neurogastroenterology. Its pharmacological properties offer valuable insights into the mechanisms underlying gut function and related therapeutic strategies. -
Tertiary Amine Metabolite
Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine, a skeletal muscle relaxant that exerts its effects on the central nervous system. This compound is formed in liver particles and is subject to enzymatic reduction by liver cytosolic reductases, converting it back to the parent amine. Cyclobenzaprine N-oxide serves as a valuable tool for studying the pharmacological activity and metabolism of Cyclobenzaprine in research applications related to muscle relaxation and neuropharmacology. -
Unsaturated Hydroxy Fatty Acid
(9Z)-16-Hydroxy-9-hexadecenoic acid is an unsaturated hydroxy fatty acid that serves as a bioactive compound in various biological processes. This fatty acid can be generated through the fermentation of Methyl palmitoleate using the yeast Torulopsis apicola. Its unique structural features contribute to its role in lipid metabolism and may have implications in studying metabolic pathways and related diseases. -
Azelastine Metabolite
Desmethylazelastine is the primary active metabolite of Azelastine, functioning as a selective and high-affinity antagonist of the histamine H1 receptor. With a protein binding rate of 97% and an elimination half-life of 54 hours, it plays a significant role in the pharmacological effects of Azelastine. This compound is valuable for research applications involving allergic rhinitis, asthma, diabetic hyperlipidemia, and studies related to SARS-CoV-2. -
Metabolite of Felbamate
SCH 54388 is an orally active metabolite of Felbamate, primarily targeting GABA and NMDA receptors. This compound significantly diminishes functional impairments associated with cognitive deficits induced by agents such as Scopolamine and Dizocilpine. SCH 54388 is suitable for research focused on cognitive impairment and neuroprotective mechanisms. -
Arachidonic acid Metabolite
8(S),9(R)-EET is an eicosanoid metabolite derived from arachidonic acid, produced through the enzymatic action of cytochrome P450. This compound exhibits potent vasodilatory effects, demonstrated by its ability to dilate canine epicardial arterioles in a concentration-dependent manner, with an EC50 value of 121 nM. 8(S),9(R)-EET is valuable in research applications focused on cardiovascular function and the role of arachidonic acid metabolites in vascular biology. -
H1R Antagonist
Fexofenadine Impurity F is a derivative of Fexofenadine, primarily acting as a histamine H1 receptor (H1R) antagonist. This compound exhibits biological activity associated with anti-allergic properties, making it relevant in the study of allergic reactions and potential therapeutic interventions for conditions such as seasonal allergic rhinitis and chronic idiopathic urticaria. It serves as a useful reagent for research in drug development and impurity profiling. -
Endogenous metabolites
Bicyclo-PGE2 is a stable decomposition product of prostaglandin E2 (PGE2) and 13,14-dihydro-15-ketone PGE2. This compound is recognized for its relevance in studying the biological effects of endogenous metabolites. Its unique structure allows researchers to investigate the biochemical pathways influenced by prostaglandins and their role in various physiological processes. Bicyclo-PGE2 is a valuable tool for exploring cell signaling mechanisms and inflammatory responses in various biological systems. -
Drug Metabolite
Bifenazate-diazene is a significant degradation product of Bifenazate, a selective carbazate acaricide and insecticide. This compound serves as a valuable tool for studying the metabolic pathways of Bifenazate, enabling researchers to investigate its environmental fate and bioactivity. Its applications extend to evaluating the effects of Bifenazate and its metabolites on various biological systems, contributing to the understanding of pesticide behavior and safety. -
Drug Metabolite
Ro 14-6113 is an inactive phenolic metabolite of the carotenoid compound Ro 15-0778, which is a derivative of vitamin A. This reagent serves as an important tool in studying the metabolic pathways of carotenoids and their influence on biological systems. It can be utilized in various research applications related to vitamin A metabolism and its physiological effects. -
Drug Metabolite
Avitinib-methyl is a drug metabolite of Avitinib, primarily functioning as a biomarker for pharmacokinetic studies. It plays a significant role in assessing drug metabolism and pharmacodynamics, particularly in understanding the bioavailability and efficacy of Avitinib in clinical research. This compound is valuable for researchers investigating the therapeutic window and safety profiles associated with Avitinib treatments. -
Hepatoprotective Agent
Tetrahydro bellidifolin is a hepatoprotective agent derived from the hydrolysis of tetrahydroswertianolin by β-glucosidase. It demonstrates significant hepatoprotective activity, effectively reducing serum alanine aminotransferase (ALT) levels. This compound is valuable for research focused on liver injury and its protective mechanisms. -
Drug Metabolite
Lurasidone Metabolite 14283-d8 is the deuterated form of the Lurasidone metabolite 14283, serving as a valuable tool for drug metabolism studies. This particular metabolite plays a significant role in understanding the pharmacokinetics and pharmacodynamics of Lurasidone. Researchers can utilize Lurasidone Metabolite 14283-d8 to trace metabolic pathways and quantify drug levels in biological samples, aiding in the development of therapeutic strategies. -
Drug Metabolite
8-Demethyl Ivabradine is a drug metabolite of Ivabradine, specifically targeting hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This compound can be utilized in research to study the pharmacokinetics and pharmacodynamics of Ivabradine. Its role in modulating cardiac rhythm makes it relevant for investigations into cardiovascular physiology and therapeutic interventions. -
Drug Metabolite
Simvastatin Acyl-β-D-glucuronide is a primary metabolite of Simvastatin, which functions as a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. This compound plays a significant role in the pharmacokinetics of Simvastatin and is utilized in research applications focused on lipid metabolism and cholesterol regulation. Its analysis can provide insights into the metabolic pathways and efficacy of statin therapeutics. -
Drug Metabolite
T-705RMP is a phosphorylated metabolite of T-705 that primarily targets IMP dehydrogenase (IMPDH) activities in host cells. It demonstrates a very weak inhibitory effect, with an IC50 value of 601 μM. This compound can be utilized in research applications examining the metabolic pathways of antiviral agents and their effects on cellular processes. -
Drug Metabolite
5,6-Epoxy-13-cis retinoic acid is a drug metabolite of 13-cis retinoic acid, primarily involved in retinoid metabolism. This compound serves as a relevant research tool for studying the pharmacokinetics and pharmacodynamics of retinoids, particularly in the context of skin and cancer therapies. Its structural properties make it significant for investigations into metabolite interactions and their biological effects. -
Ilaprazole Metabolite
Ilaprazole sulfone is the primary metabolite of Ilaprazole, primarily formed through the activity of cytochrome P450 enzymes CYP3A4 and CYP3A5. As a metabolite of an oral proton pump inhibitor, Ilaprazole sulfone holds relevance in pharmacokinetic studies and the evaluation of drug interactions. Its examination may provide insights into the efficacy and safety profiles of proton pump inhibitors in clinical settings. -
FXR Agonist
Tauro-obeticholic acid is an active metabolite of obeticholic acid, functioning as a potent farnesoid-X receptor (FXR) agonist. This compound exhibits significant biological activity in the regulation of bile acid homeostasis and lipid metabolism. It is primarily utilized in research exploring metabolic disorders, liver diseases, and potential therapeutic interventions targeting FXR pathways. -
Endogenous Metabolite
N,N,O-Tridesmethylvenlafaxine is an endogenous metabolite of venlafaxine, primarily known for its role in modulating serotonin and norepinephrine reuptake. This compound has been utilized in pharmacokinetic studies to assess drug metabolism and its effects on therapeutic outcomes. Its relevance in research extends to investigations of depression and anxiety disorders, facilitating a deeper understanding of the pharmacological profiles of related antidepressants. -
Drug Metabolite
(S)-2-Ketodoxapram is a drug metabolite of Doxapram, which functions as a respiratory stimulant. This compound is crucial for studying the pharmacokinetics and metabolic pathways of Doxapram in various biological systems. It enables researchers to investigate its effects on respiration and potential therapeutic applications in respiratory disorders. -
Drug Metabolite
Chondroitin disaccharide Δdi-0S sodium is a drug metabolite derived from the degradation of Chondroitin sulfate. This unsaturated disaccharide can undergo derivatization with 2-aminopyridine to generate a fluorescent pyridylamino derivative, facilitating investigations into the metabolic pathway of Chondroitin sulfate. It is particularly useful for studying related disease mechanisms and elucidating the role of chondroitin in biologic systems. -
Drug Metabolite
2-Deoxokanshone L is a drug metabolite derived from the degradation of Nardosinone. It serves as a valuable marker in pharmacokinetic studies, aiding in the understanding of drug metabolism and disposition. This compound is essential for researchers investigating the metabolic pathways and therapeutic implications of Nardosinone and related compounds. -
Drug Metabolite Control
S-Methyl-D-penicillamine is a metabolite of the chelating agent Penicillamine, primarily involved in drug metabolite control. This compound exhibits significant biological activity in metal ion chelation, contributing to the detoxification and clearance of heavy metals from biological systems. It is employed in research applications focused on understanding metal metabolism and the biochemical pathways of chelation therapy. -
Drug Metabolite Control
7-APB hydrochloride is a benzofuran compound and a known metabolite of 7-MAPB. It serves as a valuable tool in drug metabolite control studies, enabling researchers to investigate the pharmacokinetics and metabolic pathways of related substances. Its application in toxicology and pharmacology research enhances the understanding of drug interactions and safety profiles in various biological contexts. -
Drug Metabolite
S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SF-cysteine) serves as a drug metabolite derived from Sulforaphane. This compound has demonstrated the ability to enhance the survival rate of Nalm-6 cells in cellular studies. Its potential applications in research may include investigations into cellular response mechanisms and protective effects of dietary phytochemicals. SF-cysteine represents a valuable tool for exploring the biochemical pathways associated with cancer and other diseases. -
Drug Metabolite
4,5-Desisopropylidene topiramate is a significant metabolite of Topiramate, primarily serving as a drug metabolite. This compound is important for studying the pharmacokinetics and pharmacodynamics of Topiramate, which is utilized in the treatment of epilepsy and migraine disorders. Researchers can leverage its unique properties to explore metabolic pathways and the drug's efficacy in various clinical contexts. -
Drug Metabolite
7-Hydroxy etodolac is a metabolite of etodolac, a non-steroidal anti-inflammatory drug that functions as a cyclooxygenase (COX) inhibitor. This compound is of interest in pharmacokinetic studies and metabolism research, providing insights into the metabolic pathways of NSAIDs. Its investigation can enhance the understanding of drug efficacy and safety profiles in therapeutic applications. -
Drug Metabolite
15-Hydroxy Lubiprostone is an active metabolite of the laxative drug Lubiprostone, primarily targeting chloride channels. This compound exhibits biological activity by promoting fluid secretion in the intestinal lumen, thereby facilitating bowel movements. It is mainly utilized in research applications focused on gastrointestinal pharmacology and the mechanisms of action related to chloride channel activation. -
Drug Metabolite
3-Hydroxy desalkylgidazepam is the active metabolite of Gidazepam, playing a crucial role in the pharmacokinetics of this compound. This metabolite exhibits biological activity relevant to the study of benzodiazepine metabolism and its effects on the central nervous system. Research applications include investigations into drug interactions, toxicology studies, and the assessment of pharmacological profiles of related compounds. -
Drug Metabolite
3-(Methylphosphinico)propionic acid is a known metabolite of the herbicide glufosinate ammonium, with implications for environmental monitoring and toxicology studies. This compound's biological activity can provide insights into the degradation pathways of glufosinate and its potential effects on ecosystems. Researchers utilize this metabolite to assess the presence and impact of herbicide residues in agricultural environments. -
Drug Metabolite
Raloxifene Bismethyl Ether is a drug metabolite derived from Raloxifene, characterized by the absence of both hydroxyl groups, rendering it inactive at estrogen receptors. This compound serves as a useful tool in pharmacokinetic studies to explore metabolic pathways and the biological effects of Raloxifene and its derivatives. Its stability and metabolic profile can aid in understanding its role in therapeutic applications and safety evaluations. -
Drug Metabolite Control
AB-CHMINACA metabolite M5A is a liver-derived metabolite of the synthetic cannabinoid AB-CHMINACA. It serves as a crucial component for drug metabolite control studies, offering insights into the pharmacokinetics of AB-CHMINACA and its effects on human health. This metabolite is valuable for toxicological research and forensic analysis related to synthetic cannabinoids. -
Drug Metabolite Control
(±)13,14-EDT is an oxylipin and a metabolite of adrenic acid, produced through the cytochrome P450 (CYP) metabolic pathway. This compound serves as a valuable control in drug metabolism studies, aiding in the understanding of the biotransformation processes of various pharmaceuticals. Its biological activity is crucial for elucidating the effects of drug metabolites on physiological responses, making it an important reagent for researchers investigating drug metabolism and toxicity. -
Metabolite
JANEX-1-M is a metabolite of JANEX-1, a selective inhibitor of Janus kinase 3 (JAK3). This compound is known to effectively inhibit mast cell degranulation and the subsequent release of pro-inflammatory mediators. JANEX-1-M is utilized in research focused on inflammatory responses and the modulation of immune system activity. -
Drug Metabolite Control
2-Amino-2'-chloro-5-nitrobenzophenone is a compound known for its role as a precursor in the synthesis of benzodiazepines. This reagent also serves as a hydrolysis product of Clonazepam, making it relevant for studies focused on drug metabolite control. Its biological activity is essential for research applications in pharmacology and toxicology, particularly in examining drug metabolism and the effects of benzodiazepine derivatives. -
Drug Metabolite
13(S)-HODE-biotin is a biotinylated derivative of 13(S)-hydroxyoctadecadienoic acid, a lipoxygenase metabolite of linoleic acid. It plays a critical role in regulating cellular responses, including modulation of platelet-activating factor and leukotriene B4, as well as calcium influx in human polymorphonuclear leukocytes. This compound is valuable for research applications involving lipid signaling pathways and inflammation studies. -
Drug Metabolite
Captopril EP Impurity J is a drug metabolite associated with the antihypertensive agent Captopril, a thiol-containing competitive angiotensin-converting enzyme (ACE) inhibitor. With an IC50 of 0.025 μM, it plays a crucial role in the modulation of blood pressure by inhibiting the conversion of angiotensin I to angiotensin II. This impurity is significant for research applications focused on drug metabolism and pharmacokinetics, enabling the study of the metabolic pathways and potential effects of Captopril. -
Drug Metabolite
Netupitant N-oxide is the primary metabolite of Netupitant, a highly selective antagonist of the neurokinin-1 (NK1) receptor. This compound is crucial for studying the pharmacokinetics and pharmacodynamics of Netupitant, contributing to the understanding of its efficacy and safety profile in clinical settings. It is particularly useful in research focusing on antiemetic therapies and the modulation of pain and anxiety pathways. -
Drug Metabolite
Dihydroechinofuran is a benzoquinone metabolite with significant relevance in drug metabolism studies. It serves as a useful tool for understanding biotransformation processes and the pharmacokinetics of various therapeutic agents. Research applications include the investigation of metabolic pathways and the assessment of drug interactions.
