Catalog No.
Product Name
Application
Product Information
Citations
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Drug Metabolite
(S)-Menthiafolic acid is a naturally occurring drug metabolite derived from grape sources. It plays a significant role in the aroma profile of wines, produced during the alcoholic and malolactic fermentation processes from its glucose ester precursor. This compound is of interest in research related to wine chemistry and the modulation of sensory properties in fermented products. -
Drug Metabolite
CNJ-294 is a drug metabolite and an intermediate in the synthesis of Capmatinib. It plays a crucial role in understanding the metabolic pathways and pharmacokinetics of Capmatinib. Research applications of CNJ-294 include studies on drug metabolism, efficacy, and safety in the context of specific cancer therapies. -
Drug Metabolite
(Rac)-Mono(3,5,5-trimethylhexyl) phthalate is an important drug metabolite associated with phthalate plasticizers. This compound exhibits immunosuppressive effects, making it relevant for studies investigating the pharmacokinetics and toxicology of environmental pollutants. Its characterization aids in understanding the biological impact of plasticizers on human health and ecology. -
Drug Metabolite
7-Hydroxycannabidiol (7-OH-CBD) is a primary metabolite of cannabidiol, primarily functioning as a biomarker in drug metabolism studies. It is found in human serum and saliva, making it significant for pharmacokinetic research and therapeutic monitoring of cannabidiol-based treatments. This compound is essential for understanding the metabolic pathways of cannabinoids and their physiological effects. -
Drug Metabolite
3-Hydroxy-4-methyl-2(5H)-thiophenone is a key drug metabolite and a major acidic degradation product of Cephalexin. This compound plays a crucial role in pharmacokinetic studies and is essential for investigating the metabolic pathways of cephalosporin antibiotics. Its characterization can enhance the understanding of drug stability and efficacy in therapeutic applications. -
Drug Metabolite
Ethyl mycophenolate is a drug metabolite related to the prodrug mycophenolate mofetil, which primarily targets the immune system. It is often detected as a potential impurity in commercial formulations of mycophenolic acid, a compound widely used for immunosuppression in transplant patients. This metabolite is critical for studies examining drug efficacy, safety, and pharmacokinetics in clinical and research settings. -
Drug Metabolite
15-Keto latanoprost acid is a metabolite of latanoprost that demonstrates modest biological activity. This compound has been shown to induce a small reduction in intraocular pressure (1 mm Hg) in normal cynomolgus monkeys when administered at a dose of 1 μg/eye. Additionally, 15-keto latanoprost exhibits miotic effects in cat eyes, causing an 8 mm Hg decrease in pupillary diameter at a concentration of 5 μg/eye. Its applications may be relevant for research involving ocular pharmacology and the mechanisms of prostaglandin action. -
Drug Metabolite
4-Hydroxytryptophol is a drug metabolite primarily involved in the metabolism of psilocin. This compound is identified in human liver microsomes and recombinant monoamine oxidase A systems, serving as an important tool for studying the pharmacokinetics and metabolic pathways of tryptamines. Although 4-hydroxytryptophol is not present in in vivo samples from mice or humans, its characterization in vitro provides valuable insights for research applications in drug metabolism and psychiatry. -
Drug Metabolite Control
Hydroxymethyl tolperisone hydrochloride is a metabolite of tolperisone, primarily formed by the cytochrome P450 isoform CYP2D6, with minor contributions from CYP2C19 and CYP1A2. This compound serves as an important analytical standard for drug metabolite control in pharmacokinetic studies. It plays a crucial role in evaluating metabolic pathways and potential drug interactions during research applications. -
Drug Metabolite Control
2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride is a metabolite of the anorectic agent Mazindol, functioning as a drug metabolite control. This compound is essential for studying the pharmacokinetics and metabolic pathways of Mazindol, aiding in understanding its pharmacological effects and safety profile. It is useful in research applications related to drug metabolism and therapeutic monitoring. -
Drug Metabolite
o-Desmethyl ranolazine is a drug metabolite formed through the metabolic conversion of Ranolazine by cytochrome P450 (CYP) 3A enzymes. This compound serves as an important reference in pharmacokinetic studies and can be utilized in research investigating the metabolism of therapeutic agents, particularly in the context of cardiovascular disease. Its biological activity and metabolic pathways are valuable for understanding drug efficacy and safety profiles. -
Drug Metabolite
Reduced Haloperidol, a primary metabolite of Haloperidol, functions as a dopamine receptor antagonist. It exhibits significant antipsychotic activity, primarily utilized in research related to schizophrenia and other psychotic disorders. This compound is instrumental in studies investigating the modulation of neurotransmitter systems, aiding in the reduction of hallucinations and delusions associated with these conditions. -
Drug Metabolite
Ketopynalin is a drug metabolite derived from Vatalanib. It plays a crucial role in the metabolism and pharmacokinetics of Vatalanib, making it significant for studies focused on the drug's efficacy and safety. Researchers can utilize Ketopynalin to investigate the metabolic pathways and biological effects associated with Vatalanib in various cellular and animal models. -
Drug Metabolite
(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, functioning primarily as a non-nucleoside inhibitor of HIV-1 reverse transcriptase. This compound exhibits significant biological activity in the context of HIV research, contributing to the understanding of drug metabolism and efficacy. It is relevant for studies focusing on the pharmacokinetics and potential resistance mechanisms associated with antiretroviral therapy. -
Drug Metabolite
1-(Hydroxymethyl)-5,5-dimethylhydantoin is a drug metabolite derived from the degradation of 1,3-dimethylol-5,5-dimethylhydantoin, a compound known for its formaldehyde-releasing and antimicrobial properties. This reagent serves as a valuable reference standard in pharmacokinetic studies and investigations into metabolite behavior. Its applications extend to toxicological research, where understanding its effects and interactions can contribute to safety assessments of formaldehyde-releasing agents in various formulations. -
Drug Metabolite
1,2-Diacetylbenzene is a γ-diketone metabolite that serves as an important model for studying the reactivity of aromatic hydrocarbons with proteins. Primarily derived from the neurotoxic solvent 1,2-diethylbenzene, this compound exhibits significant biological activity and is utilized in research investigating metabolic pathways, protein interactions, and toxicological impacts. Its reactive properties make it a valuable asset in the examination of related biochemical processes. -
Drug Metabolite Control
AB-PINACA 3-Carboxyindazole metabolite is a key metabolite of the synthetic cannabinoid APINAC. This compound plays a significant role in drug metabolite control, aiding in the investigation of the metabolic pathways of synthetic cannabinoids. Its analytical applications are particularly useful in toxicology and forensic science, providing essential insights into substance use and metabolism. -
Drug Metabolite
Dibutyl 3-hydroxybutyl phosphate is a significant metabolite of tris(n-butyl) phosphate (TNBP), which is widely utilized as an alkyl organophosphate ester. This compound serves as an important reference in studies of TNBP metabolism and its biological effects. Research applications include investigations into metabolic pathways and the toxicity of organophosphate esters in biological systems. -
Drug Metabolite
Fipronil sulfide is a toxic and persistent metabolite of the insecticide Fipronil, which acts primarily on the insect central nervous system by inhibiting gamma-aminobutyric acid (GABA) receptors. This compound exhibits significant biological activity in studies related to environmental toxicity and the degradation pathways of pesticides. Research applications include assessing the impact of fipronil metabolites on non-target organisms and evaluating their long-term environmental effects. -
Drug Metabolite Control
9(E)-Erythromycin A oxime is a metabolite of Roxithromycin, a semi-synthetic macrolide antibiotic. This compound serves as a valuable control in drug metabolism studies, facilitating the investigation of metabolic pathways and pharmacokinetics. Its utilization in research contributes to understanding antibiotic metabolism and potential interactions within biological systems. -
Drug Metabolite
DL-Sulforaphane glutathione (DL-SFN-GSH) is a conjugate of Sulforaphane, acting primarily as a drug metabolite. It plays a crucial role in cellular detoxification and antioxidant defense mechanisms. DL-SFN-GSH is often utilized in research related to sulforaphane metabolism, oxidative stress, and the investigation of its protective effects against various diseases. -
Drug Metabolite Control
4-Hydroxypentanoate sodium is an active metabolite of gamma-Valerolactone, functioning primarily as a sedative. Its primary mechanism involves modulation of GABA receptors, leading to enhanced inhibitory neurotransmission. This compound is utilized in pharmacological research to study drug metabolism and to evaluate sedative effects in various experimental models. -
Drug Metabolite
Fenretinide glucuronide, a drug metabolite, is produced via the glucuronidation of Fenretinide. This conversion increases the water solubility of Fenretinide, promoting its excretion. Fenretinide glucuronide is of significant interest for research applications in cancer studies, offering insights into the pharmacokinetics and biological effects of Fenretinide in cancer treatment. -
Drug Metabolite
5-O-Desmethyl omeprazole is a metabolic product of the proton pump inhibitor Omeprazole, generated through the action of cytochrome P450 enzymes. This compound is crucial for studying drug metabolism and pharmacokinetics, particularly in understanding the biotransformation of Omeprazole. Its analysis can provide insight into drug interactions and the therapeutic efficacy of proton pump inhibitors in clinical research. -
Drug Metabolite
DDOH, a metabolite of DTT, primarily functions as a conjugating agent by forming derivatives with palmitic acid. This compound is significant for studies in metabolic processes and the examination of drug metabolism. Its ability to form conjugates makes it valuable for research involving lipid metabolism and the pharmacokinetics of drug conjugation. -
Drug metabolite
3α,5α-Tetrahydronorethisterone is a significant urinary metabolite of the synthetic progestin, Norethisterone. It plays a crucial role in pharmacokinetic studies, particularly in the assessment of progestin metabolism and elimination in clinical and research settings. Its identification and quantification can provide valuable insights into hormonal pathways and drug efficacy. -
Drug Metabolite Control
7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one is a primary metabolite of Flubromazepam, acting on the central nervous system through modulation of GABA receptors. This compound exhibits potential anxiolytic and sedative properties, making it relevant for studies on drug metabolism and pharmacokinetics. Its application is beneficial in research focused on benzodiazepine derivatives and their metabolic pathways. -
Drug Metabolite
Para-Naphthol Duloxetine is a drug metabolite derived from Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI). This compound is important for understanding the pharmacokinetics and pharmacodynamics of Duloxetine, as it may contribute to the drug's efficacy and side effect profile. Research applications include studies on metabolic pathways, drug interactions, and the therapeutic effects of SNRIs in various clinical contexts. -
Drug Metabolite Control
Nicorandil pyridine oxide is a metabolite of Nicorandil, which acts as an activator of the sulfonylurea receptor 2B (SUR2B) and the ATP-sensitive potassium channel Kir6.2. This compound serves as a crucial tool for drug metabolite control, offering insights into the pharmacokinetics and therapeutic mechanisms of Nicorandil. Its biological activity is important for researchers studying cardiovascular effects and the modulation of ion channels in various biological systems. -
Drug Metabolite
Diphenhydramine N-oxide is a metabolite of Diphenhydramine, a first-generation H1 receptor antagonist known for its anticholinergic properties. This reagent serves as an important tool for studying the pharmacokinetics and metabolic pathways of Diphenhydramine, particularly in relation to its central nervous system effects. Researchers can utilize Diphenhydramine N-oxide to investigate its role in drug metabolism and potential therapeutic implications in various biological systems. -
Drug Metabolite
2,3,4,5-Tetrachlorophenol is a drug metabolite derived from the insecticide γ-Lindane. This compound is utilized in research to study metabolic pathways and environmental persistence of chlorinated phenolic compounds. Its biological activity provides insights into the toxicity and ecological impact of pesticide degradation products, making it valuable for toxicological and environmental studies. -
Drug Metabolite
5-Hydroxy flunixin, the primary metabolite of Flunixin, acts as a potent anti-inflammatory agent by retaining the pharmacological properties of its parent compound. This metabolite significantly contributes to pain relief and inflammation reduction in veterinary medicine, addressing conditions such as equine colic, musculoskeletal disorders, and infectious diseases in cattle. Additionally, it supports the management of mastitis-metritis-agalactia syndrome in sows, making it valuable for various therapeutic applications in animal health. -
Drug Metabolite Control
α-Hydroxy flualprazolam is a hydroxylated metabolite of flualprazolam, functioning primarily as a drug metabolite control. This compound exhibits key biological activity by interacting with GABA-A receptors, contributing to its pharmacological effects. Its applications extend to forensic toxicology and drug screening, providing valuable insights in the detection of benzodiazepine metabolites in biological samples. -
Moxifloxacin Metabolite
Moxifloxacin N-sulfate is a metabolite of the fluoroquinolone antibiotic moxifloxacin. This compound is primarily used in pharmacokinetic studies to better understand the metabolism and excretion of moxifloxacin in biological systems. Its analysis plays a crucial role in toxicology, safety assessment, and the evaluation of therapeutic efficacy in various research applications. -
Drug Metabolite
Para-hydroxy 2-methyl AP-237 hydrochloride is a key metabolite of 2-methyl AP-237. This compound is significant in drug metabolism studies, aiding in the understanding of metabolic pathways and the pharmacokinetics of its parent compound. Research applications include evaluating metabolic stability and assessing the impact of metabolism on therapeutic efficacy and safety profiles. -
Endogenous Metabolite
3-Methylcrotonyl CoA is an endogenous metabolite that serves as a critical intermediate in the leucine catabolism pathway. It is converted to 3-Methylglutaconyl CoA via the enzyme 3-Methylcrotonyl CoA Carboxylase. Accumulation of 3-Methylglutaconyl CoA due to mutations in 3-Methylglutaconyl-CoA Hydratase can result in metabolic disorders, such as 3MGA-uria. This compound is valuable for investigating metabolic diseases linked to disruptions in the leucine degradation pathway. -
Drug Metabolite Control
2-Amino-2'-fluoro-5-nitrobenzophenone is a key precursor in the synthesis of benzodiazepines, functioning as an important metabolite in drug development and research. This compound serves as an acid hydrolysis product of Flunitrazepam, making it significant for studies on drug metabolism and pharmacokinetics. Its ability to be utilized in the synthesis of benzodiazepine compounds highlights its relevance in medicinal chemistry and therapeutic research. -
Drug Metabolite
Aripiprazole N,N-Dioxide is a metabolite of the atypical antipsychotic agent aripiprazole, produced through its oxidative metabolism. This compound serves as an important research tool for studying the pharmacokinetics and metabolic pathways of aripiprazole. Its characterization can aid in understanding the drug's efficacy and side effects, as well as investigations into antipsychotic drug mechanisms. -
Drug Metabolite Control
5-Methoxy-N-isopropyl tryptamine is a tryptamine derivative primarily utilized as a drug metabolite control. This compound plays a significant role in pharmacological studies, providing insights into the metabolic pathways of psychoactive substances. Its biological activity facilitates research applications in neuropharmacology and toxicology, aiding in the understanding of drug interactions and effects. -
Drug Metabolite
N-desmethyl Netupitant is a drug metabolite of Netupitant, primarily involved in the pharmacokinetic evaluation of antiemetic therapies. This compound plays a significant role in understanding the drug's metabolism, bioavailability, and overall efficacy in clinical applications. Researchers can utilize N-desmethyl Netupitant in studies focused on drug interactions, metabolic pathways, and therapeutic outcomes in the treatment of nausea and vomiting. -
Drug Metabolite Control
Alphitonin is a flavonoid that serves as a metabolic intermediate in the catabolic pathway of Quercetin by the human gut bacterium E. ramulus. Its role in drug metabolism makes it a valuable compound for studies investigating the biotransformation and bioavailability of flavonoids. Research applications include examining the interactions between gut microbiota and flavonoid metabolism, as well as investigating potential health benefits associated with flavonoid consumption. -
Drug Metabolite Control
PB-22 N-pentanoic acid metabolite is a primary metabolite of the synthetic cannabinoid PB-22. This compound serves as a crucial marker for drug metabolite control, aiding in the detection and quantification of cannabinoid presence in biological samples. Its analytical utility is essential for pharmacokinetic studies and substance abuse research. -
Drug Metabolite Control
14S(15R)-EET methyl ester is a cytochrome P450 metabolite of arachidonic acid, functioning as an oxylipin. It plays a critical role in various biological processes, including modulating vascular tone and inflammation. This compound is valuable for research applications focusing on lipid signaling pathways and drug metabolism studies. -
MAO A Inhibitor
MD 770222 is a selective and reversible inhibitor of monoamine oxidase A (MAO A). As a major O-demethyl metabolite of Cimoxatone, it exhibits notable inhibitory activity, albeit with reduced potency compared to its parent compound. This reagent is valuable in research focused on neurotransmitter modulation, neuropsychiatric disorders, and the understanding of MAO A's role in various biological processes. -
Drug Metabolite
Norzopiclone is the inactive metabolite of the hypnotic drug Zopiclone. It exhibits notable anxiolytic properties, contributing to its potential applications in research focused on sleep disorders and anxiety-related conditions. This compound is useful for studying the pharmacokinetics of Zopiclone and its effects on the central nervous system. -
NAMPT Activator
NAMPT activator-9 is an allosteric, non-competitive activator of nicotinamide adenine dinucleotide (NAD+) biosynthesis, targeting the enzyme NAMPT with an EC50 of 3.366 μM. This compound enhances NAMPT's enzymatic activity, leading to increased intracellular NAD+ levels. Furthermore, NAMPT activator-9 has been shown to restore myotube diameter and decrease the expression of muscle atrophy markers Atrogin-1 and MuRF1, making it a valuable tool for research on muscle atrophy and related metabolic disorders. -
Endogenous Metabolite
Histone H1 (calf thymus) is a linker histone subtype that plays a crucial role in the organization and stabilization of chromatin structure within eukaryotic cells. This protein is involved in the regulation of gene expression and DNA compaction. It is primarily used in research applications related to epigenetics, chromatin biology, and studies on gene regulation mechanisms. Histone H1 is obtained through separation and purification from total calf thymus histones, ensuring high purity for experimental use. -
Endogenous Metabolite
D-Glucose-13C6 is a stable isotope-labeled derivative of D-glucose, targeting metabolic pathways involving glucose. This compound serves as an effective metabolic tracer for studying glucose metabolism and synthetic catabolism. Additionally, it can be utilized as a synthesis ingredient, minimal media reagent, or internal standard in various biochemical assays. -
RXR Agonist
MSU-42011 is an orally active retinoid X receptor (RXR) agonist that demonstrates significant immunomodulatory and antitumor properties. This compound effectively inhibits inducible nitric oxide synthase (iNOS) activity and downregulates the expression of phosphorylated extracellular signal-regulated kinase (p-ERK) protein. MSU-42011 is a valuable tool for research applications focused on cancer biology and immunology. -
Lipoxygenase Inhibitor
Umbelliprenin is a prenylated coumarin that functions as a lipoxygenase inhibitor. It exhibits significant antioxidant properties along with anticancer, anti-inflammatory, and immunomodulatory activities. This compound effectively suppresses nitric oxide production in inflammatory macrophages, as well as inhibiting the expression of inducible nitric oxide synthase (iNOS). Umbelliprenin holds promise for research applications in the fields of inflammation, cancer biology, and immunology.
