Catalog No.
Product Name
Application
Product Information
Citations
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Drug Metabolite
2S,4R-Sacubitril is a drug metabolite of Sacubitril, which inhibits neprilysin, leading to increased levels of natriuretic peptides. Its biological activity supports the treatment of heart failure in combination with valsartan, enhancing cardiovascular outcomes. This compound is valuable for research on drug metabolism and the pharmacological effects of heart failure therapies. -
Drug Metabolite
(S)-O-Desmethyl Venlafaxine N-Oxide is a major N-oxide metabolite of the active compound (S)-O-Desmethyl Venlafaxine, which itself is an important metabolite of the antidepressant Venlafaxine. This compound primarily targets serotonin and norepinephrine reuptake mechanisms, contributing to its pharmacological effects. It is valuable for research in understanding metabolic pathways and the pharmacodynamics of SNRIs in therapeutic settings. -
Drug Metabolite
(R)-Desmethylcitalopram oxalate is a drug metabolite derived from Citalopram. It plays a significant role in research related to neurological diseases, serving as a valuable tool for studying the pharmacokinetics and pharmacodynamics of antidepressant therapies. This compound allows for the exploration of synaptic mechanisms and potential therapeutic applications in mood disorders. -
Drug Metabolite
(±)17(18)-EpETE methyl ester is a drug metabolite derived from eicosapentaenoic acid (EPA). This compound functions as a mediator in various physiological processes and exhibits anti-inflammatory properties. It is essential in research investigating the metabolic pathways of EPA and its role in modulating inflammatory responses, potentially contributing to therapeutic strategies for inflammatory diseases. -
Drug metabolite
Ginsenoside V is a bioactive metabolite derived from Ginsenoside Rb1, primarily known for its role in modulating cellular signaling pathways. It exhibits various biological activities, including anti-inflammatory and antioxidant effects, making it relevant in research focused on pharmacological applications and herbal medicine studies. Ginsenoside V serves as an important compound for investigating the therapeutic potential of ginseng and its effects on human health. -
Drug Metabolite
1-epi-Regadenoson is an α-isomer impurity of Regadenoson, a potent and selective agonist for the adenosine A2A receptor. This compound is primarily used in research to investigate the pharmacological effects of adenosine receptor activation and its implications in cardiovascular function. The study of 1-epi-Regadenoson can aid in understanding the metabolic pathways and potential therapeutic effects associated with adenosine receptor modulation. -
Drug Metabolite
Pseudoerythromycin A enol ether is a notable degradation product of Erythromycin. As a drug metabolite, it serves as a valuable tool for studying metabolic pathways and the pharmacokinetics of macrolide antibiotics. While it does not exhibit significant antimicrobial activity, its role in research is crucial for understanding the biotransformation of erythromycin and its derivatives. -
Drug Metabolite
Trimetazidine-N-oxide is the primary active metabolite of Trimetazidine, known for its selective inhibition of long-chain 3-ketoyl coenzyme A thiolase, with an IC50 of 75 nM. This compound exhibits significant antianginal effects and possesses additional biological activities, including antioxidant, anti-inflammatory, antinociceptive, and gastroprotective properties. Trimetazidine-N-oxide serves as a valuable reagent for studies related to cardiac health, metabolic disorders, and the exploration of therapeutic mechanisms underlying these actions. -
Drug Metabolite
3α-Hydroxy pravastatin sodium is the principal metabolite of pravastatin, functioning as a competitive inhibitor of HMG-CoA reductase. This compound is implicated in the regulation of cholesterol biosynthesis and plays a crucial role in lipid metabolism studies. Its biological activity makes it valuable for research applications focusing on cardiovascular diseases and the pharmacokinetics of statin therapies. -
H1-Receptor Antagonist
Cetirizine Impurity B dihydrochloride is an impurity of the H1-receptor antagonist, cetirizine dihydrochloride. While cetirizine demonstrates significant antiallergic properties and effectively inhibits eosinophil chemotaxis during allergic responses, this specific impurity is valuable for analytical purposes and quality control in research applications. It aids researchers in understanding the pharmacological profile and potential effects associated with cetirizine and its metabolites. -
Drug Metabolite
N-(2-Hydroxyethyl)oxamic acid is a drug metabolite that results from the reduction of Metronidazole, either through chemical means or the action of intestinal bacteria. As a derivative of the nitroimidazole antibiotic, it exhibits activity against a range of protozoans as well as most Gram-negative and Gram-positive anaerobic bacteria. This metabolite is valuable for research into antibiotic metabolism and the pharmacokinetics of Metronidazole. -
Drug Metabolite
(3R,5R)-Octahydrocurcumin is a gut microbial metabolite of Curcumin that acts as a neuroprotective agent. It demonstrates protective efficacy against Aβ25-35-induced cytotoxicity in SH-SY5Y cells and exhibits anti-inflammatory effects in LPS-stimulated mouse microglial BV-2 cells. This compound is valuable for research applications focused on neurodegenerative diseases and inflammation-related studies. -
Drug Metabolite
1-β-D-Glucosylsphingadienine (d18:2 (4E8E)) is a glucosylsphingosine derivative that serves as a key metabolite in the metabolism of glucosylcerebrosides. This compound exhibits important biological activity, influencing cellular signaling pathways and lipid metabolism. Its applications are significant in the study of lysolipid function and the pathological mechanisms underlying certain metabolic disorders. -
Drug Metabolite
2-Methylamino-1-phenylbutane hydrochloride is a primary metabolite of various stimulant agents, specifically involved in the pharmacokinetics of these compounds. This reagent is significant for research applications in toxicology and pharmacology, assisting in the analysis of drug metabolism and the assessment of stimulant effects in biological samples. Its utility extends to studies focused on understanding the biochemical pathways influenced by stimulant drugs. -
Drug Metabolite
2-Deoxokanshone M, a drug metabolite derived from Nardosinone, exhibits significant vasodilatory properties. This compound serves as a valuable tool in studying vascular biology and the pharmacokinetics of Nardosinone, contributing to research on its therapeutic applications in cardiovascular conditions. Its ability to modulate vascular tone makes it an important reagent for investigations into blood pressure regulation and related disorders. -
Drug metabolite
Isokotanin B is a metabolite derived from bicoumarin, obtained from the sclerotia of Aspergillus alliaceus. It demonstrates noteworthy biological activity against agricultural pests, specifically the corn earworm (Helicoverpa zea) and the dried fruit beetle (Carpophilus hemipterus). This compound serves as a valuable tool for research in pest management and biopesticide development. -
Fungal Metabolite
(3S,5S)-Octahydrocurcumin, a fungal metabolite derived from Curcuma longa, functions as a potent antioxidant. This compound exhibits significant biological activity, particularly in modulating oxidative stress pathways. Its unique properties make it a valuable tool in research focused on inflammation, neuroprotection, and the therapeutic potential of curcumin derivatives. -
Drug Metabolite
N-Desmethyl-U-47700 is the primary metabolite of U-47700, functioning as an opioid receptor agonist. This compound exhibits significant analgesic properties and is relevant in research focused on opioid metabolism and pharmacokinetics. It serves as a critical tool for studying the effects and mechanisms of action associated with opioid compounds in various biological settings. -
Drug Metabolite
Silodosin Glucuronide sodium is the sodium salt of Silodosin β-D-glucuronide, a metabolite of the selective α1A-adrenergic receptor antagonist Silodosin. It exhibits high affinity for the α1A-AR, facilitating a Ki value of 0.036 nM. This compound is crucial for studying the pharmacokinetics and metabolic pathways of Silodosin, contributing to research applications in urology and cardiovascular studies. -
Drug Metabolite
Cyclo(Tyr-Val), also known as Cyclo(L-Tyr-L-Val), is a diketopiperazine secondary metabolite derived from the fungus Neurospora gilva. It has been identified for its potential role in drug metabolism studies, serving as a valuable tool for researchers investigating metabolic pathways and the pharmacokinetics of various compounds. Its unique structure and biological activity make it suitable for applications in biochemical research and drug development. -
Drug Metabolite
Buspirone N-oxide is a metabolite of Buspirone, a known 5-HT1A receptor agonist and dopamine D2 autoreceptor antagonist. This compound is significant in studying the pharmacokinetics and metabolic pathways of Buspirone. Due to its origin from an established anxiolytic agent, Buspirone N-oxide can be utilized in research related to generalized anxiety disorder and the evaluation of anxiety-modulating pathways. -
Drug Metabolite
Oxoprolintane is a primary metabolite of the psychoactive compound Prolintane, targeting the central nervous system. It plays a crucial role in the regulation of neurophysiological processes and presents potential neuroprotective properties. This compound is utilized in research focused on neurological diseases, providing insight into its therapeutic implications and mechanisms of action. -
Drug Metabolite
Tetranor-12(R)-HETE is a significant metabolite of 12(R)-HETE, formed through β-oxidation processes. This compound plays a crucial role in various metabolic pathways and has implications in studies involving lipid signaling and inflammatory responses. Its investigation can provide insights into the physiological and pathological mechanisms associated with eicosanoids. Tetranor-12(R)-HETE is useful for research applications in drug metabolism and the study of bioactive lipid mediators. -
Drug Metabolite
Carvedilol Glucuronide is a significant metabolite of the β/α-1 adrenergic receptor antagonist, Carvedilol. This compound demonstrates key biological activity by modulating β-adrenergic signaling and exhibits potential application in studying the metabolic pathway of Carvedilol. Research indicates that Carvedilol can inhibit lipid peroxidation and has properties as an antihypertensive agent, as well as an autophagy inducer that affects the NLRP3 inflammasome. Carvedilol Glucuronide serves as an important reagent for investigating drug metabolism and pharmacokinetics in cardiovascular research. -
Drug Metabolite
Florfenicol amine is the active metabolite of the veterinary antibiotic Florfenicol, known for its efficacy in combating susceptible bacterial infections in aquaculture. This compound plays a critical role in understanding the pharmacokinetics and safety of Florfenicol in various biological systems. Research applications include studying drug metabolism and evaluating the environmental impact of veterinary pharmaceuticals. -
Fungal Metabolite
5-Acetamidopentanoic acid is a fungal metabolite known for its role in various biochemical pathways. It exhibits potential biological activity that may influence metabolic processes in fungi. This compound is primarily used in research focused on mycology, microbial metabolism, and the study of fungal secondary metabolites. -
Pre-Emergence Herbicide
Trifluralin is a selective pre-emergence herbicide that targets the mitotic process in plant cells. By binding to tubulin, it disrupts spindle apparatus formation and inhibits root development, effectively controlling a range of annual grass and broadleaf weed species. This mechanism of action makes Trifluralin particularly useful in agricultural research focused on weed management and crop protection. Notably, it also possesses neurotoxic and hematotoxic properties, which may have implications for environmental and health studies. -
NAMPT Activator
Carba1 is a bifunctional carbazole derivative that acts as an activator of nicotinamide phosphoribosyltransferase (NAMPT), thereby enhancing NAD biosynthesis. This compound also binds to the colchicine site of tubulin, which can potentiate the anticancer effects of various chemotherapeutic agents, including Paclitaxel. Additionally, Carba1 displays neuroprotective properties and is capable of modulating cellular energy metabolism. It is suitable for research applications focused on cancer therapies and chemotherapy-induced peripheral neuropathy (CIPN). -
Aha1/Hsp90 Complex Inhibitor
Aha1/Hsp90-IN-1 is a potent inhibitor of the Aha1/Hsp90 complex, demonstrating an IC50 value of 3.32 μM. By disrupting the interactions between Aha1 and Hsp90, this compound effectively inhibits tau aggregation. Research applications include studies of protein folding and aggregation diseases, making it a valuable tool in the exploration of neurodegenerative disorders. -
Herbicide
Dinitramine is a selective herbicide that primarily targets the Erk/P38/JNK/MAPK signaling pathways while inhibiting the PI3K/Akt pathway, leading to significant cellular stress responses. This compound induces endoplasmic reticulum stress and disrupts calcium homeostasis, resulting in apoptosis and reduced expression of cell cycle regulatory genes in testicular cells. In addition to its cytotoxic effects, Dinitramine has been shown to impair embryonic development in zebrafish, causing abnormal heart formation, inhibited angiogenesis, and increased inflammatory responses. These activities highlight its potential applications in studying cellular signaling, developmental biology, and herbicidal mechanisms. -
Serine/Threonine Kinase Inhibitor
ST045945 is a selective inhibitor of serine/threonine kinases, specifically targeting CHK1 and CHK2 pathways that regulate cell cycle checkpoints. This compound effectively induces G2/M phase arrest in tumor cells, leading to DNA damage and inhibition of cell proliferation. ST045945 is utilized in cancer research to explore therapeutic strategies by disrupting critical signaling pathways associated with tumor progression and resistance to chemotherapy. -
Mononucleotide
2'-Deoxyguanosine 5'-monophosphate disodium is a nucleotide analog targeting cellular processes associated with guanine. This mononucleotide serves as a key reactant in studies of self-assembly in solution and the nucleation and growth of G-quadruplex structures. In addition, it plays a role in nucleophilic trapping and reductive alkylation, making it valuable for research on oxidative stress and DNA synthesis. As a precursor to guanosine triphosphate (GTP), it is essential for various biochemical assays and applications in nucleic acid research. -
Endogenous Metabolite
8-Oxo-dATP lithium is an oxidized purine nucleoside triphosphate that targets the MTH1 enzyme. This compound plays a crucial role in cellular metabolism by being hydrolyzed into monophosphates, which effectively prevents the misincorporation of 8-oxo-dATP during DNA replication and transcription processes. It is applicable in research concerning oxidative stress, DNA damage repair mechanisms, and the fidelity of nucleotide incorporation in cellular systems. -
Fungal Metabolite
3α,11β,21-Trihydroxy-20-oxo-5β-pregnan-18-al is a fungal metabolite known for its role in biological processes associated with gut fungi. This compound exhibits various biological activities that contribute to the understanding of fungal metabolism and its impact on human health. It serves as a valuable research tool in studies investigating the interactions between gut microbiota and host physiology. -
5-LO/COX Inhibitor
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) enzymes, exhibiting an IC50 of 5 μM for 5-LO. It also demonstrates inhibitory activity against COX-1 and COX-2, with IC50 values of 0.65 and 1.2 μg/mL, respectively. This compound is valuable for research applications involving inflammation and other related pathways. Its ability to concurrently inhibit key lipid mediators makes BW 755C a useful tool in studies focused on arachidonic acid metabolism and signaling pathways. -
COX-2/5-LOX Inhibitor
Tebufelone is a selective dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO). It exhibits significant anti-inflammatory, analgesic, and antipyretic properties, making it useful for research into inflammatory pathways. This compound is valuable for studying the roles of COX-2 and 5-LO in various biological processes and assessing novel therapeutic strategies for inflammatory diseases. -
Dual COX/5-LOX Inhibitor
ER-34122 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LO). This compound exhibits significant anti-inflammatory activity, making it valuable for research into inflammation-related pathways. ER-34122 is particularly relevant for studies investigating the interplay between COX and 5-LO pathways in various disease models and therapeutic contexts. -
Endogenous Metabolite
C16-18:1 PC (1-O-Hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine) is an endogenous metabolite and a pro-inflammatory lipid mediator from the platelet-activating factor (PAF) family of glycerophospholipids. This compound exhibits diverse biological activities and plays a significant role in signaling pathways related to inflammation. C16-18:1 PC can be utilized in research applications involving lipid metabolism, cell signaling, and inflammatory processes, providing insights into the underlying mechanisms of various diseases. -
Anti-inflammatory Agent
trans-Isoferulic acid, an aromatic acid and potent anti-inflammatory agent, is derived from the roots of Clematis florida var. plena. It effectively inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by inducing Nrf2-dependent heme oxygenase-1 (HO-1). This compound is valuable for research applications focused on inflammation pathways and the modulation of oxidative stress. -
5-LO/PGE2 Inhibitor
Canniprene is a potent inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2), with IC50 values of 0.4 μM and 10 μM, respectively. Derived from Cannabis sativa, Canniprene modifies the biosynthesis of inflammatory eicosanoids and prostaglandins, making it a valuable tool for researching inflammation and related pathways. Its unique mechanism of action positions Canniprene as a potential candidate for studying inflammatory diseases and therapeutic interventions targeting lipid mediators. -
Phospholipase Activator
9-Oxononanoic acid is a potent phospholipase A2 (PLA2) activator that arises as a secondary product of lipid peroxidation. It stimulates the production of thromboxane A2 (TXA2) and promotes platelet aggregation in human blood, making it a valuable tool for studying platelet function and related cardiovascular processes. Its oral bioavailability enhances its utility in various in vivo research applications. -
TXA2/5-Lipoxygenase Inhibitor
CV-6504 is a dual inhibitor targeting thromboxane A2 (TXA2) synthase and 5-lipoxygenase. This compound demonstrates significant biological activity by scavenging reactive oxygen species (ROS) and exhibiting antitumor properties. CV-6504 is applicable in research focused on cancer, inflammation, and cardiovascular diseases, providing valuable insights into therapeutic strategies and molecular mechanisms. -
5-Lipoxygenase/Thromboxane Synthase Inhibitor
E 3040 is an orally active inhibitor of both 5-lipoxygenase and thromboxane synthase, key enzymes involved in inflammatory processes. This dual inhibition provides significant anti-inflammatory activity, making E 3040 a valuable reagent for research into inflammatory diseases and related pathways. Its unique mechanism can facilitate studies on the modulation of leukotrienes and thromboxanes in various biological contexts. -
Stable Isotope
trans-Isoferulic acid-d3 is a deuterium-labeled derivative of trans-Isoferulic acid, a naturally occurring aromatic acid derived from Clematis florida var. plena. This compound possesses notable anti-inflammatory properties, primarily through its ability to suppress nitric oxide (NO) and prostaglandin E2 (PGE2) production. Its mechanism of action involves the induction of Nrf2-dependent heme oxygenase-1 (HO-1), making it valuable for research into cellular stress responses and inflammation pathways. -
Endogenous metabolites
Prostaglandin F1β is a C-9 epimer of prostaglandin F1α, primarily targeting endogenous metabolites in biological systems. It is known to enhance respiratory rates in rabbits, making it valuable for research applications in respiratory physiology and metabolic regulation. Additionally, its role in various signaling pathways opens avenues for studying inflammatory processes and reproductive biology. -
PDE2 Inhibitor
ND-7001 is a potent inhibitor of phosphodiesterase 2 (PDE2) with an IC50 value of 0.05 μM, demonstrating significant selectivity against PDE3 and PDE4. This compound effectively elevates cGMP levels in primary neuronal cultures derived from rat cerebral cortical neurons, contributing to its role in modulating neuronal signaling. ND-7001 is primarily utilized in research focused on anxiety disorders and neuropharmacology, highlighting its potential for evaluating anxiolytic mechanisms. -
5-LO/TXA2 Inhibitor
E-6700 is a potent inhibitor of 5-lipoxygenase (5-LO) and thromboxane A2 (TXA2) synthetase, with IC50 values of 16.3 μM and 0.026 μM, respectively. This compound effectively inhibits the production of leukotriene B4 (LTB4) and thromboxane B2 (TXB2). E-6700 is suitable for applications in anti-inflammatory research, providing a valuable tool for investigating pathways associated with inflammatory responses. -
Endogenous metabolites
5-trans Prostaglandin F2β is an endogenous metabolite and a key isomer of 5-trans Prostaglandin F2α, specifically the 9β-hydroxy form. This compound plays a significant role in various physiological processes, including vasodilation and modulation of reproductive functions. Its primary applications include research in cardiovascular biology and reproductive health, providing valuable insights into prostaglandin signaling pathways and their effects on cellular responses. -
Drug Metabolite
16-Phenyl tetranor Prostaglandin F2α is a metabolically stable analog of Prostaglandin F2α, targeting the FP receptor. Although it exhibits lower affinity at the FP receptor in ovine luteal cells (8.7%) compared to its parent compound, it serves as a valuable tool in pharmacological research. Its unique stability and receptor interaction profile make it suitable for studies involving prostaglandin signaling pathways and reproductive biology. -
KRAS-PDEδ Interaction Inhibitor
Atrovastatin-PEG3-FITC is a KRAS-PDEδ interaction inhibitor that serves as a valuable tool in the study of KRAS signaling pathways. This compound can function as a ligand in fluorescence anisotropy assays, enabling researchers to investigate protein-protein interactions and their implications in cancer biology. Its application aids in understanding the role of KRAS in various malignancies and exploring potential therapeutic interventions.
