Catalog No.
Product Name
Application
Product Information
Citations
-
Ferroptosis Inhibitor
YL-939 is a potent inhibitor of ferroptosis, a regulated form of cell death characterized by the accumulation of lipid peroxides. It acts by targeting the PHB2/ferritin/iron axis, effectively modulating iron metabolism and oxidative stress. This compound is valuable for research applications focused on neurodegeneration, cancer, and other diseases where ferroptosis plays a critical role. -
Ferroptosis Inhibitor
CuATSM is a copper complex that serves as a potent inhibitor of ferroptosis through the scavenging of free radicals and inhibition of lipid peroxidation. This compound demonstrates significant antioxidant and anti-inflammatory properties, making it valuable for addressing neuroprotection in various research contexts. CuATSM is suitable for studies exploring cellular stress responses and neurodegenerative disorders. -
Ferroptosis Inducer
Piperazine Erastin is a ferroptosis inducer that triggers an iron-dependent form of non-apoptotic cell death. This compound is instrumental in cancer research, providing valuable insights into the mechanisms of ferroptosis and potential therapeutic applications in oncology. Its unique action offers a powerful tool for studying cellular metabolism and death pathways in various cancer models. -
Ferroptosis Inducer
Angelic acid is a ferroptosis inducer that targets NRF2 degradation. By binding to the NRF2 protein, it facilitates its ubiquitination and subsequent proteasomal degradation, thereby mitigating the protective effects of NRF2 against oxidative stress and promoting lipid peroxidation. This process leads to the induction of ferroptosis in tumor cells, evidenced by increased intracellular reactive oxygen species (ROS) and upregulation of ferroptosis-related markers such as CHAC1 and PTGS2. Additionally, Angelic acid exhibits the ability to scavenge UVA-induced ROS, inhibiting skin fibroblast senescence and extracellular matrix degradation, and promotes wound healing through its sedative properties. -
Ferroptosis/ATF3 Inhibitor
ATF3-IN-1 is a potent inhibitor of ATF3, targeting the ATF3/SLC7A11/GPX4 pathway to mitigate ferroptosis and oxidative stress. This compound demonstrates significant neuroprotective effects, particularly in conditions of ischemia/reperfusion (I/R) injury, promoting neuronal survival in ischemic stroke models. ATF3-IN-1 is valuable for research into therapeutic strategies for neuroprotection and the underlying mechanisms of ischemic stroke. -
Cysteine Protease
Cathepsin B, Bovine spleen is a cysteine protease that plays a critical role in various forms of programmed cell death, including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death. This enzyme is instrumental in research applications focused on understanding cellular mechanisms of death and disease progression. Additionally, it serves as a valuable tool for investigating proteolytic processes in both physiological and pathological contexts. -
Ferroptosis Inhibitor
Moracin N is a potent ferroptosis inhibitor derived from mulberry leaves. It demonstrates neuroprotective activity by mitigating oxidative stress, providing valuable insights into the mechanisms of cell survival under stress conditions. This compound is applicable in research exploring neurodegenerative diseases and ferroptosis-related pathways. -
Endogenous Metabolite; Nrf2 Activator; ROS Inhibitor
L-Cystine hydrochloride is an endogenous metabolite that serves as a potent Nrf2 activator and reactive oxygen species (ROS) inhibitor. It enhances Nrf2 protein expression, facilitating transcriptional responses that combat oxidative stress. Research indicates that L-Cystine hydrochloride reduces ROS generation and protects cells from apoptosis induced by oxidants or Doxorubicin. Additionally, its combination with L-theanine has been shown to boost antigen-specific IgG production by elevating glutathione levels and promoting T helper 2 (Th2) responses. This compound has significant potential for studying cystinuria and kidney stone formation. -
Apoptotis/Ferroptosis Activator
Ardisiacrispin B is an apoptosis and ferroptosis activator. It exhibits cytotoxic effects in cancer cells that are resistant to multiple treatments, promoting cell death through the induction of ferroptosis and apoptosis pathways. This compound is valuable for research applications focused on understanding resistance mechanisms in cancer and exploring therapeutic strategies that leverage ferroptotic cell death. -
Ferroptosis Inhibitor
SRS16-86 is a potent ferroptosis inhibitor that provides enhanced stability in vivo compared to other inhibitors. This compound is effective in research applications involving renal ischemia-reperfusion injury and spinal cord injury, making it a valuable tool for investigating ferroptosis-related pathways and therapeutic interventions. SRS16-86 allows researchers to explore the mechanisms of ferroptosis and its implications in various diseases. -
Carbonic Anhydrase Inhibitor
Zonisamide is an orally active inhibitor of carbonic anhydrases, demonstrating Ki values of 35.2 nM for human carbonic anhydrase II and 20.6 nM for human carbonic anhydrase V. This compound exhibits neuroprotective properties by promoting anti-apoptotic mechanisms and enhancing manganese superoxide dismutase (MnSOD) expression. Additionally, Zonisamide has been shown to upregulate Hrd1 expression, which contributes to improved cardiac function in animal models of cardiac hypertrophy. Research applications include investigations into seizures, Parkinson's disease, and cardiac hypertrophy. -
PDEIII Inhibitor
Anagrelide hydrochloride is a selective phosphodiesterase type III (PDE3) inhibitor with an IC50 value of 36 nM. This imidazoquinazoline derivative effectively inhibits platelet aggregation and suppresses megakaryocyte development in the bone marrow. Additionally, Anagrelide hydrochloride has been shown to reduce the proliferation of gastrointestinal stromal tumor (GIST) cells and induce apoptosis in vitro, highlighting its potential as an antineoplastic agent. Its primary application lies in its role as a platelet-lowering agent with antithrombopoietic properties. -
ALDH Inhibitor/Local Anaesthetic
Dyclonine hydrochloride is a potent inhibitor of aldehyde dehydrogenases (ALDH), specifically targeting ALDH2 with an IC50 of 35 μM and ALDH3A1 with an IC50 of 76 μM. This compound exhibits notable biological activities, including the sensitization of targeted cancer cells and antibacterial properties. Additionally, Dyclonine hydrochloride serves as a local anesthetic, effectively inhibiting nerve impulse transmission and alleviating pain sensations. Its ability to cross the blood-brain barrier further enhances its utility in various research applications. -
IDH1-R132H Inhibitor
Alpha-Mangostin is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1-R132H), demonstrating a Ki of 2.85 μM. This dietary xanthone exhibits a diverse range of biological activities, including antioxidant, anti-inflammatory, antibacterial, and anticancer properties. It is valuable for research applications exploring metabolic pathways in cancer and the development of targeted therapies against IDH1-mutant tumors. -
Selective RXR Agonist
AGN194204 is a selective retinoid X receptor (RXR) agonist with high affinity, exhibiting Kd values of 0.4 nM, 3.6 nM, and 3.8 nM for RXRα, RXRβ, and RXRγ, respectively, and EC50 values of 0.2 nM, 0.8 nM, and 0.08 nM. This compound is devoid of activity against retinoic acid receptors (RAR). AGN194204 demonstrates significant anti-inflammatory and anticarcinogenic properties, making it a valuable tool for research in inflammation and cancer biology. -
Endogenous Metabolite
L-Proline is an endogenous metabolite and a designated amino acid that serves as a critical building block for protein synthesis in living organisms. It plays a significant role in collagen formation, wound healing, and cellular signaling. L-Proline is commonly utilized in biochemical research to study protein conformation, metabolic pathways, and the effects of amino acid modulation on various physiological processes. -
PPAR-α/γ and PPAR-γ Agonist
Dehydroabietic acid is a diterpene resin acid that serves as a dual agonist for PPAR-α and PPAR-γ, with partial agonist activity at PPAR-γ. This compound exhibits significant biological activities, including anti-bacterial, anti-fungal, anti-inflammatory, and anti-cancer effects. It has been shown to mitigate insulin resistance and hepatic steatosis induced by high-fat diet consumption in animal models, making it a valuable reagent for research in metabolic disorders and inflammatory diseases. -
Antioxidant
4,5-Dicaffeoylquinic acid is a potent antioxidant primarily targeting cellular oxidative stress. This compound, derived from Gynura divaricata and Laggera alata, exhibits significant biological activities, including the reduction of islet cell apoptosis and enhancement of pancreatic function in type 2 diabetic models. It effectively inhibits yeast α-glucosidase and demonstrates anti-cancer properties through cell cycle arrest in prostate cancer cells. Additionally, 4,5-Dicaffeoylquinic acid possesses anti-apoptotic effects and shows potential in protecting against liver injury and hepatitis B virus infection, making it valuable in various research applications. -
Monoamine Oxidase Inhibitor
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 value of 3 μM, making it a valuable tool in neuropharmacological research. In addition to its MAO inhibitory activity, isatin also interacts with central benzodiazepine receptors (IC50 against clonazepam, 123 μM) and acts as an antagonist of both atrial natriuretic peptide-stimulated and nitric oxide-stimulated guanylate cyclase activity. This compound's multiple mechanisms of action highlight its potential in studying the serotonergic system and its related pathways in various biological contexts. -
Endogenous Metabolite
Stearic acid is a long-chain saturated fatty acid that functions as an endogenous metabolite. It has been shown to induce apoptosis in preadipocytes, resulting in a significant reduction of visceral fat. This compound is valuable for research in cardiovascular and metabolic diseases, providing insights into lipid metabolism and adipocyte function. -
Endogenous Metabolite
Sodium Demethylcantharidate is an endogenous metabolite that plays a role in various biological processes. This compound is utilized in research to study metabolic pathways and potential physiological effects. Its biological activity may provide insights into its contribution to cell signaling and metabolic regulation. -
HMG-CoA Reductase Inhibitor
Pitavastatin is a potent HMG-CoA reductase inhibitor that effectively reduces cholesterol synthesis from acetic acid, demonstrating an IC50 of 5.8 nM in HepG2 cells. This compound functions as a potent inducer of low-density lipoprotein-cholesterol (LDL-C) receptors in hepatocytes. Additionally, Pitavastatin exhibits a broad range of biological activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects, making it valuable for research in cardiovascular health and metabolic disorders. -
RAR Agonist
Adapalene sodium salt is a potent retinoic acid receptor (RAR) agonist, demonstrating significant binding affinity with AC50 values of 2.3 nM for RARβ, 9.3 nM for RARγ, and 22 nM for RARα. This third-generation synthetic retinoid is primarily utilized in acne research but has also been identified to inhibit the enzymatic activity of glutamate oxaloacetate transaminase 1 (GOT1) in a non-competitive manner. Additionally, adapalene sodium salt exhibits anti-tumor activity, making it valuable for diverse biological studies. -
CYP51 Inhibitor
CYP51-IN-30 is a potent inhibitor of CYP51, targeting sterol 14α-demethylase, an essential enzyme in sterol biosynthesis. This compound exhibits significant fungicidal activity, demonstrated by an EC50 value of 2.97 mg/L against Sclerotinia sclerotiorum. Its efficacy makes it a valuable tool for research in antifungal studies and applications in plant pathology. -
Antifungal Metabolite
Dihydrocompactin is an antifungal metabolite that acts primarily as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMG-CoA reductase). This compound, derived from Penicillium citrinum, exhibits significant antifungal activity and is valuable in studying fungal infections and metabolic pathways. Dihydrocompactin may be used in research focused on the development of antifungal agents and the elucidation of HMG-CoA reductase's role in cellular processes. -
Fungal Metabolite
Gymnoascolide A is a fungal metabolite derived from M. filamentosa, recognized for its vasodilatory properties. At a concentration of 1 µM, it effectively inhibits calcium-induced contractions in isolated rat aortic rings, highlighting its potential role in vascular research. This compound may be valuable for studying mechanisms of vasodilation and the modulation of vascular tone. -
15-LOX Inhibitor
Asperenone is a potent inhibitor of 15-lipoxygenase (15-LOX), with an IC50 value of 0.3 mM, and effectively inhibits platelet aggregation at an IC50 of 0.23 mM. This compound also exhibits antifungal properties, demonstrating the ability to inhibit the growth of pathogenic fungi such as Ophiostoma crassivaginatum and O. piliferum. Asperenone is valuable for research in cardiovascular disease and antifungal therapy, providing a multifaceted approach to studying inflammatory processes and infection control. -
Succinate Dehydrogenase Inhibitor
SDH-IN-38 is a potent inhibitor of succinate dehydrogenase, primarily targeting mycelial respiration. Demonstrating significant antifungal activity, SDH-IN-38 exhibits an EC50 value of 0.009 μg/mL against R. solani mycelia, effectively inhibiting mycelial growth. Additionally, this compound induces cellular senescence and reduces mitochondrial membrane potential in fungal cells, making it a valuable tool for research in fungal biology and disease management. -
ALS Inhibitor/Herbicide
Penoxsulam is a potent acetolactate synthase (ALS) inhibitor that functions as a selective herbicide. It effectively inhibits the enzyme acetohydroxyacid synthase (AHAS) in Candida auris with a Ki value of less than 32 nM. This agent is primarily utilized for postemergence control of annual grasses, sedges, and broadleaf weeds in rice agriculture. Additionally, Penoxsulam serves as a useful tool for investigating Candida auris infections in research contexts. -
Antibiotic
Cyclamidomycin is an acrylamide antibiotic that primarily targets nucleoside diphosphate kinase and pyruvate kinase in Escherichia coli, along with impairing oxidative phosphorylation in rat liver mitochondria. It exhibits broad-spectrum antibacterial activity against various bacteria, including Staphylococcus aureus, Micrococcus flavus, Staphylococcus lutea, Bacillus subtilis, Escherichia coli, Shigella flexneri, Salmonella typhosa, Proteus vulgaris, and Klebsiella pneumoniae, with minimum inhibitory concentrations ranging from 3.12 to 25 mg/ml. This compound is valuable for research on bacterial infections and mitochondrial function. -
CYP51 Inhibitor
CYP51-IN-32 is a selective inhibitor of CYP51, demonstrating a potent antifungal activity with an IC50 of 0.331 μM against Candida albicans. This compound not only inhibits the growth of Candida albicans by disrupting hyphal formation and biofilm development, but it also releases hydrogen sulfide (H2S), contributing to its antifungal effects. CYP51-IN-32 is suitable for investigating Candida albicans infections and can be formulated into PEG-based nanovesicles for enhanced delivery in research applications. -
DHFR Inhibitor
DHFR-IN-25 is a potent inhibitor of dihydrofolate reductase (DHFR), demonstrating broad-spectrum antibacterial activity. This compound exhibits significant efficacy against pathogens such as Candida albicans and Staphylococcus aureus. DHFR-IN-25 is particularly valuable for research applications focusing on local anti-infection strategies and the development of antimicrobial therapies. -
CYP51 Inhibitor
(Rac)-Ketoconazole is an imidazole antifungal agent that acts as a potent inhibitor of cytochrome P450-dependent 14α-sterol demethylase (CYP51). By disrupting ergosterol synthesis, it induces membrane dysfunction, thereby inhibiting the growth and reproduction of various fungi. This compound is primarily utilized in research relating to fungal infections and the mechanisms of antifungal resistance. -
Fungal Metabolite
Tenellin is a fungal metabolite derived from Beauveria, known for its inhibitory effects on ATPase activities, specifically Mg2+, Ca2+, and Na+/K+-ATPases, in equine erythrocytes, achieving inhibition rates of 51%, 57%, and 74% at a concentration of 200 μg/mL. Additionally, Tenellin exhibits cytotoxicity against Sf9 and Sf21 insect cell lines, with CC50 values of 4.84 μM and 11.95 μM, respectively. This compound is valuable for research into fungal metabolism and its potential effects on cellular processes in insects. -
Hsp90 Inhibitor
NSC145366 monohydrochloride is an inhibitor of the Hsp90 chaperone protein, specifically targeting its C-terminal domain. By directly interacting with Hsp90, it effectively disrupts its chaperone activity, leading to a significant reduction in cellular growth. This compound has been shown to strongly inhibit the proliferation of Saccharomyces cerevisiae strains, specifically cog7Δ and cog8Δ, making it a valuable tool for research into protein homeostasis and cellular stress response pathways. -
Fungal CYP51A1 Inh
Becliconazole functions as an inhibitor of the fungal cytochrome P450 51A1 (CYP51A1) enzyme. This compound exhibits significant antifungal activity and is primarily utilized in research related to fungal infections, offering insights into the mechanisms of action and potential therapeutic interventions against fungal pathogens. -
CYP51 Inhibitor
Pipercroside A is a potent CYP51 inhibitor derived from Piper crocatum Ruiz & Pav. This compound exhibits significant antifungal activity, making it a valuable tool in studies of fungal infections and drug resistance mechanisms. Its role in inhibiting sterol biosynthesis positions Pipercroside A as a candidate for further investigation in antifungal therapeutic development. -
Fungal Metabolite
Glioroseinol is a fungal metabolite derived from Gliocladium, exhibiting potential bioactive properties. This compound is of interest for its role in studying fungal interactions and biological pathways. Research applications include investigations into natural products and their pharmacological effects in various biological systems. -
CYP51 Inhibitor
Pipercroside B is a potent inhibitor of CYP51, an essential enzyme in sterol biosynthesis. Isolated from Piper crocatum Ruiz & Pav, this compound exhibits significant antifungal activity, making it valuable for research into antifungal therapeutics. Its role in modulating CYP51 provides insights into fungal metabolism and potential treatment strategies against fungal infections. -
Pyruvate Kinase Inhibitor
PKR-IN-1 is an inhibitor of pyruvate kinase, demonstrating potent antifungal activity with an EC50 of 0.21 μg/mL against Rhizoctonia solani. Its primary mechanism involves the inhibition of glycolytic metabolism, which is crucial for fungal growth and survival. This compound is valuable for research applications focused on the development of antifungal strategies and the study of metabolic pathways in fungi. -
Succinate Dehydrogenase Inhibitor
Siccanin is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.9 μM with selective activity across species. In addition to its role as an SDH inhibitor, Siccanin demonstrates antimicrobial properties against pathogenic fungi. This compound is valuable for research applications focused on metabolic processes and the treatment of fungal infections. -
Succinate Dehydrogenase Inhibitor
SDH-IN-7 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 26 nM against porcine SDH. This compound demonstrates significant fungicidal activity, making it a valuable tool for research applications focused on mitochondrial metabolism and fungal pathogenicity. Its inhibitory effect on SDH suggests potential implications in cancer research and metabolic studies. -
Endogenous Metabolite
E-α-Bisabolene is a non-cyclic sesquiterpene that serves as an endogenous metabolite within the metabolic network of Phanerochaete chrysosporium. This compound plays a critical role in the biosynthesis of secondary metabolites by white-rot fungi, thereby contributing to their ecological functions and interactions. E-α-Bisabolene is valuable for studies in fungal metabolism and can be utilized in research exploring natural product synthesis. -
Fungal Metabolite
1233B is a secondary metabolite derived from the filamentous fungus Fusarium sp. RK97-94. This compound exhibits significant antifungal activity, making it a valuable reagent for studying fungal biology and the development of antifungal therapies. Researchers can utilize 1233B in various applications, including pharmacological screening and the investigation of fungal resistance mechanisms. -
Fungal Metabolite
Trichodecenin II is a fungal metabolite derived from the conidia of the fungus Trichoderma viride. This compound exhibits significant biological activity that may play a role in fungal development and physiology. It is primarily utilized in research applications aimed at understanding fungal metabolism and interactions, making it a valuable tool in mycological studies. -
Endogenous Metabolite
Deacetylsclerotiorin is an endogenous metabolite derived from chloramphenicol, sourced from the fungus Bartalinia robillardoides strain LF550. This compound demonstrates significant antifungal activity, effectively inhibiting Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM), and Septoria tritici (IC50=7.45 μM). Furthermore, Deacetylsclerotiorin inhibits phosphodiesterase 4 (PDE4) with an IC50 of 2.8 μM, highlighting its potential utility in enzyme inhibition studies and antifungal research applications. -
HSP90 Inhibitor
HSP90-IN-9 is a highly potent and selective inhibitor of the heat shock protein 90 (HSP90). This compound exhibits pronounced fungicidal activity in a dose-dependent manner and effectively inhibits fungal biofilm formation and morphological alterations when used in conjunction with fluconazole (FLC). Additionally, HSP90-IN-9 enhances FLC sensitivity by down-regulating the expression of key resistance-related genes, including ERG11, CDR1, and CDR2, making it a valuable tool for research applications in antifungal resistance studies. -
Hsp90 Inhibitor
Hsp90-IN-41 is a potent inhibitor of Heat Shock Protein 90 (Hsp90) with an IC50 of 0.044 μM. This compound demonstrates significant antifungal and antitumor activity, exhibiting an IC50 of 0.049 μM in vitro. It is valuable for research applications related to cancer and fungal diseases, particularly in studying the therapeutic potential of Hsp90 modulation. -
Antifungal Agent
Decussatin is an α-Amylase inhibitor derived from the Tibetan medicinal plant Swertia mussotii. By inhibiting the enzymatic activity of α-Amylases, Decussatin effectively reduces the hydrolysis of complex carbohydrates, leading to decreased glucose absorption in the intestines and lower blood glucose levels. While it demonstrates limited antibacterial and antifungal properties, Decussatin is primarily utilized in the study of type 2 diabetes and its management. -
Fungal Metabolite
Heveadride is a fungal metabolite that functions as an antifungal agent. It exhibits activity against a range of filamentous fungi as well as certain human pathogenic yeasts. Additionally, Heveadride has been shown to induce down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells, with an IC50 of 82.7 μM, making it a valuable tool for research in antifungal treatments and cancer biology.
