Catalog No.
Product Name
Application
Product Information
Citations
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Melanocortin Receptor Agonist
Resomelagon is a potent orally active melanocortin receptor agonist, primarily targeting MC1 and MC3. This compound induces ERK1/2 phosphorylation and promotes calcium mobilization, showcasing significant anti-inflammatory properties. Resomelagon is predominantly employed in research focused on obesity and chronic inflammation, providing valuable insights into metabolic and inflammatory pathways. -
Melanocortin 4 Receptor Agonist
RO27-3225 TFA is a selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating approximately 30-fold selectivity for MC4R over MC3R. This compound is recognized for its neuroprotective and anti-inflammatory properties, making it valuable in research related to metabolic regulation and inflammatory conditions. RO27-3225 TFA is suitable for studies focused on the role of MC4R in various physiological and pathological processes. -
MC2R Antagonist
GPS1573 is a noncompetitive antagonist of the melanocortin type 2 receptor (MC2R), exhibiting dose-dependent inhibition of adrenocorticotropic hormone (ACTH)-induced MC2R activity with an IC50 value of 66 nM. This compound is particularly valuable in research focused on Cushing's disease, given its high selectivity for MC2R antagonism. Its properties make GPS1573 an important tool for studying adrenal regulation and related endocrine disorders. -
MC3 Receptor Agonist
γ1-MSH is an agonist of the melanocortin MC3 receptor, exhibiting a Ki of 34 nM for the rat MC3 receptor. This compound demonstrates approximately 40-fold selectivity over the MC4 receptor, with a Ki of 1318 nM. γ1-MSH is valuable for research applications exploring the role of melanocortin receptors in metabolic processes and neuroendocrine regulation. -
MC4R Agonist
MK-0493 hydrochloride is a selective agonist of the melanocortin receptor 4 (MC4R), known for its potent and orally active properties. It has been shown to effectively reduce energy intake, making it a valuable tool for research in metabolic disorders and obesity. Its targeted mechanism of action facilitates the exploration of MC4R pathways in various biological studies. -
Melanocortin Receptor Agonist
Adrenocorticotropic Hormone (ACTH) (4-10), human is a potent agonist of the melanocortin 4 receptor (MC4R). This peptide fragment is involved in the regulation of various physiological processes, including appetite control and energy homeostasis. Its applications extend to research in metabolic disorders, obesity, and neuroendocrine function, offering insights into MC4R signaling pathways. -
ACTH Fragment
ACTH (22-39) is a fragment of adrenocorticotropic hormone (ACTH), specifically encompassing the amino acid sequence from 22 to 39. This peptide retains important biological activity relating to the stimulation of adrenal steroidogenesis, making it valuable for research in endocrinology and stress response studies. It is commonly utilized in investigations of the hypothalamic-pituitary-adrenal (HPA) axis and the mechanisms underlying adrenal function. -
MC4R Antagonist
ML00253764 is a selective antagonist of the melanocortin receptor 4 (MC4R). It induces apoptosis through the inhibition of ERK1/2 and Akt phosphorylation pathways, demonstrating notable anticancer activity. This compound is valuable for research focused on cancer biology and the modulation of melanocortin signaling pathways. -
MC3 Agonist
[D-Trp8]-γ-MSH is a selective agonist of the melanocortin 3 (MC3) receptor, exhibiting an IC50 of 6.7 nM in CHO cells. This compound also demonstrates activity against the MC4 and MC5 receptors, with IC50 values of 600 nM and 340 nM, respectively. [D-Trp8]-γ-MSH is implicated in research applications related to inflammatory disorders, showing potential neuroprotective effects in conditions such as rheumatoid arthritis and colitis. -
ACTH Analogue
(D-Ser1)-ACTH (1-24) is an analogue of adrenocorticotropic hormone (ACTH) that retains the critical biological activities associated with ACTH signaling. This peptide exhibits potent effects on cortisol secretion and adrenal cortex stimulation, making it valuable in research related to stress response, adrenal function, and endocrinology. It is suitable for studies involving various model organisms, including human, bovine, mouse, ovine, porcine, rabbit, and rat. -
ACTH Fragment
ACTH (1-16) (human) is a fragment of the adrenocorticotropic hormone that primarily targets the ACTH receptor. This peptide has been shown to enhance cardiovascular function and improve survival rates in models of experimental hemorrhagic shock. It serves as a valuable tool in research applications focused on stress response and the physiological mechanisms underlying shock and related cardiovascular conditions. -
ACTH Receptor Antagonist
ACTH (11-24) is an adrenocorticotropic hormone (ACTH) receptor antagonist that modulates cortisol release through the inhibition of ACTH receptors. This peptide fragment serves as a valuable tool for investigating endocrine regulation and its effects within the central nervous system. ACTH (11-24) is particularly useful in studies related to stress response, neuroendocrine function, and potential therapeutic applications in disorders linked to ACTH signaling. -
ACTH Receptor Antagonist
ACTH (7-38) (human) is a fragment of human adrenocorticotropic hormone (ACTH) that acts as an antagonist at the ACTH receptor. It functions as a corticotropin inhibitory peptide (CIP) and exhibits no corticosteroid activity. This reagent is useful for studies investigating adrenal function, stress response mechanisms, and the regulation of steroid hormone production. -
MC4R Agonist
Setmelanotide monoacetate is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting EC50 values of 0.27 nM in human and 0.28 nM in rat models. This compound plays a crucial role in regulating appetite and energy homeostasis, making it valuable for research applications related to obesity and metabolic disorders. Its specificity for MC4R also makes it a useful tool for studying melanocortin signaling pathways. -
Melanocortin 4 Receptor Agonist
PG-931 is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting an IC50 of 0.58 nM, while demonstrating selective activity against the human MC3R and MC5R with IC50 values of 55 nM and 2.4 nM, respectively. This compound has shown significant biological activity in reversing haemorrhagic shock and mitigating multiple organ damage in vivo. PG-931 is valuable for research applications focused on obesity, metabolic disorders, and neurodegenerative diseases involving melanocortin signaling pathways. -
Melanocortin Receptor Agonist
Resomelagon acetate is a potent, orally active melanocortin receptor (MC) agonist, primarily targeting MC1 and MC3 receptors. It effectively induces ERK1/2 phosphorylation and promotes calcium mobilization, contributing to its anti-inflammatory properties. This compound is particularly relevant for research focused on obesity and chronic inflammation. -
MC4 Receptor Antagonist
HS024 is a selective antagonist of the melanocortin-4 (MC4) receptor, exhibiting inhibition constants (Kis) of 0.29 nM for MC4, 3.29 nM for MC5, 5.45 nM for MC3, and 18.6 nM for MC1. This compound is notable for its ability to enhance food intake, making it a valuable tool for research in metabolic disorders, appetite regulation, and obesity studies. HS024 may facilitate the exploration of pathways related to energy homeostasis and weight management. -
hMC1R Agonist
hMC1R Agonist 1 selectively activates the human melanocortin 1 receptor (hMC1R) with an EC50 of 3 nM. This compound demonstrates over 300-fold selectivity for hMC1R compared to hMC3R, hMC4R, and hMC5R, which have significantly higher EC50 values (902 nM, 915 nM, and >1000 nM, respectively). hMC1R Agonist 1 holds promise for potential therapeutic applications within the melanocortin receptor family, particularly in conditions related to pigmentation and metabolic regulation. -
Melanogenesis Inhibitor
(-)-Isodocarpin is a diterpenoid that acts as a potent melanogenesis inhibitor, exhibiting an IC50 of 0.19 μM in B16 4A5 cell lines. This compound effectively suppresses the expression of key melanogenic enzymes, including tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA. (-)-Isodocarpin is valuable for research applications focused on skin pigmentation, melanin synthesis, and related dermatological studies. -
Adrenocorticotropin Hormone Fragment
ACTH (4-11) is a fragment of the adrenocorticotropin hormone that primarily interacts with melanocortin receptors, exhibiting mild α-melanocyte stimulating hormone (α-MSH) activity at elevated concentrations of 100 and 1000 nM. This compound is utilized in research applications focused on the regulation of stress responses and the study of melanocortin receptor signaling pathways. Its unique properties make it a valuable tool in investigations of physiological processes related to adrenal function and pigment regulation. -
MC4R Agonist
MC4-NN2-0453 is a selective agonist of the melanocortin 4 receptor (MC4R) and serves as an analog of alpha-melanocyte-stimulating hormone (α-MSH). This compound is particularly relevant in the study of obesity, as it stimulates MC4R activity, which is known to play a crucial role in regulating appetite and energy expenditure. Its application in obesity research allows for better understanding of mechanisms that could lead to novel therapeutic strategies. -
ACTH Fragment
Adrenocorticotropic Hormone (ACTH) (1-10), human, is a fragment of the adrenocorticotropic hormone that primarily regulates the production of cortisol in the adrenal cortex. This peptide exhibits modest α-melanocyte stimulating hormone (α-MSH) activity at elevated concentrations, specifically at 100 and 1000 nM. It is valuable in research applications related to endocrinology and stress response mechanisms, aiding in the understanding of adrenal function and pituitary signaling pathways. -
MC4R Antagonist
(2R,2R)-PF-07258669 is an antagonist of the melanocortin 4 receptor (MC4R). It serves as a valuable tool in research aimed at understanding the regulation of appetite and energy expenditure. Its application can aid in elucidating the role of MC4R in metabolic processes and potential therapeutic interventions for obesity and related disorders. -
Melanocortin Receptor Agonist
(Nle4)-α-MSH is a synthetic analogue of α-MSH and functions as a melanocortin receptor agonist. This compound is known to induce skin darkening in amphibians, specifically frog skins, and demonstrates prolonged biological activity following heat and alkali treatment. It is primarily utilized in studies related to pigmentation, skin biology, and melanocortin signaling pathways. -
α-MSH Analogue
(D-Phe7)-α-MSH is an analogue of α-melanocyte-stimulating hormone (α-MSH), a peptide hormone involved in the regulation of various physiological functions, including pigmentation and appetite control. This compound exhibits biological activity by binding to melanocortin receptors, influencing melanogenesis and potentially modulating inflammatory responses. Research applications include studies on skin pigmentation, obesity, and the role of melanocortin pathways in metabolic processes. -
Antitumor Agent
1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one is an antitumor agent that exhibits significant antiproliferative activity, with effective doses (ED50) of 57.7 μM and 78.8 μM against 26-L5 and HT-1080 cancer cell lines, respectively. Additionally, this compound has been shown to inhibit melanogenesis in B16 melanoma 4A5 cells, indicating its potential utility in studies related to skin disorders and melanoma treatment. Research involving this compound may contribute to the development of therapeutic strategies targeting cancer and pigmentation disorders. -
MC1R Agonist
Dersimelagon phosphate is a selective melanocortin 1 receptor (MC1R) agonist, exhibiting EC50 values of 8.16, 3.91, 1.14, and 0.251 nM for human, cynomolgus monkey, mouse, and rat MC1R, respectively. This compound demonstrates significant affinity for both hMC1R and hMC4R, with Ki values of 2.26 and 32.9 nM, respectively. Dersimelagon phosphate is utilized in research investigating skin pigmentation mechanisms and related biological processes. -
Melanocortin Receptor Agonist
Filimelnotide is a selective agonist of the melanocortin receptors, which are critically involved in various physiological processes including energy homeostasis and skin pigmentation. This compound has demonstrated significant biological activity in modulating appetite, body weight, and metabolic functions. Filimelnotide is particularly relevant for research in obesity, metabolic disorders, and skin-related conditions. -
MC4R Agonist
PF-00446687 hydrochloride is a selective agonist of the melanocortin 4 receptor (MC4R), exhibiting high potency with an EC50 value of 12 nM. This compound demonstrates significant brain penetration, making it suitable for studying neurological pathways. PF-00446687 hydrochloride is primarily utilized in research focused on sexual dysfunction and related metabolic disorders. -
Synthetic ACTH
β-Corticotropin (swine) is a synthetic form of adrenocorticotropic hormone (ACTH), which primarily targets adrenal cortex receptors. This peptide hormone plays a critical role in stimulating the release of steroid hormones, particularly glucocorticoids and mineralocorticoids. It is widely used in research applications focusing on stress response, adrenal function, and metabolic regulation. -
ACTH Fragment
(Phe2,Nle4)-ACTH (1-24) is a synthetic fragment of the adrenocorticotropic hormone (ACTH) that targets the melanocortin receptors. This analog exhibits biological activity relevant to the study of adrenal function and stress response mechanisms. It can be utilized in various research applications, including radiolabeling with I125 at Tyr23 to create a radiolabeled ligand for biochemical assays and receptor binding studies. -
MC4 Receptor Antagonist
HS014 is a selective antagonist of the melanocortin-4 (MC4) receptor, exhibiting a Ki of 3.16 nM for human MC4, while demonstrating significantly lower affinities for MC1, MC3, and MC5 receptors. This compound has been shown to modulate morphine-induced behaviors in murine models, as well as to facilitate increased food intake in free-feeding rat studies. HS014 is a valuable tool in research exploring the regulation of appetite and pain modulation. -
MC3 Receptor Antagonist
PG106 is a selective antagonist of the human melanocortin 3 (hMC3) receptor, exhibiting a potency with an IC50 of 210 nM. The compound demonstrates significant specificity, showing minimal activity at the hMC4 receptor (EC50 of 9900 nM) and no interaction with the hMC5 receptor. Research applications include studies focused on metabolic regulation and potential therapeutic targets related to obesity and related disorders. -
ACTH Fragment
ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment that comprises the 4-9 amino acid sequence of the full hormone. This fragment is known to interact with melanocortin receptors, influencing various physiological responses related to stress and immune function. It serves as a valuable tool in research focused on neuroendocrinology, stress response mechanisms, and the development of therapeutic agents targeting melanocortin pathways. -
Melanocortin Receptor Antagonist
MCL-0129 is a selective antagonist of the melanocortin 4 receptor (MC4R), known for its potential anxiolytic and antidepressant properties. This compound exhibits significant anxiolytic and antidepressant-like effects in various rodent models, making it a valuable tool for research into neuropsychiatric disorders. Its specific targeting of MC4R supports studies aimed at elucidating the mechanisms of action in stress-related and mood disorders. -
Melanocortin Receptor Agonist
BMS-470539 is a synthetic agonist of the melanocortin-1 receptor (MC-1R), notable for its potent anti-inflammatory properties. With EC50 values of 16.8 nM and 11.6 nM for human and murine MC-1R activation respectively, it effectively inhibits TNF-alpha-induced NF-kB activation in human melanoma cells. In vivo studies demonstrate that subcutaneous administration of BMS-470539 in BALB/c mice significantly reduces LPS-induced TNF-alpha production, leukocyte infiltration in lung inflammation, and paw swelling in delayed-type hypersensitivity models, indicating its potential as a therapeutic agent targeting inflammation through MC-1R modulation. -
Neuroprotective Agent
ORG 31433 is an orally active peptide that functions as a neuroprotective agent. It is related to the ACTH-(4-9) analog, ORG 2766, and has demonstrated significant neuroprotective effects in various preclinical studies. This compound is valuable for research applications focused on neurodegenerative diseases and neuronal injury. -
α-MSH Inhibitor
Melanostatin, frog is a potent inhibitor of α-melanocyte-stimulating hormone (α-MSH) release, exhibiting an IC50 value of 60 nM. This peptide is primarily utilized in studies investigating melanogenesis and the regulation of pigment production. Its effects on α-MSH make it a valuable tool for research applications focusing on skin biology, obesity, and related metabolic pathways. -
MCR Agonist
Melanotan I acetate is a potent non-selective agonist of melanocortin receptors (MCR). As a synthetic analogue of alpha-melanocyte stimulating hormone (α-MSH), it promotes melanogenesis and induces skin tanning by activating melanocortin type 1 receptors (MC1R) in melanocytes. This compound is valuable for research into the mechanisms of sunlight-induced skin cancers and related photobiological studies. -
ACTH Agonist
Alsactide is a heptadecapeptide analogue that functions as an adrenocorticotropic hormone (ACTH) agonist. This compound is utilized in research focusing on the central nervous system, where it may influence adrenal function and steroidogenesis. Its activity provides valuable insights into neuroendocrine regulation and potential therapeutic applications in disorders related to ACTH signaling. -
Melanogenesis Inhibitor
IIIM-8 is a melanogenesis inhibitor that effectively suppresses pigment production in both in vitro and in vivo models. This compound shows no cytotoxicity in Human Adult Epidermal Melanocytes (HAEM), making it a suitable candidate for research in hyperpigmentation disorders. Its mechanism of action supports studies aimed at understanding melanin synthesis and skin pigmentation regulation. -
Melanocortin Receptor
γ3-MSH is a peptide derived from the N-terminal segment of pro-opiomelanocortin (POMC) that primarily targets melanocortin receptors. It is known to stimulate aldosterone secretion in human adrenal tumor cells in vitro, making it a valuable tool for research into adrenal function and pathophysiology. This compound can be utilized in studies aimed at understanding the regulatory mechanisms of hormone secretion and the role of melanocortin signaling in adrenal tumors. -
MC3R/MC4R Agonist
α-MSH free acid is a potent agonist of the melanocortin receptors MC3R and MC4R, exhibiting EC50 values of 0.16 nM and 5.6 nM, respectively. This compound stimulates cAMP production upon receptor activation, making it a valuable tool for research in metabolic regulation, appetite control, and neurobiology. Its effects on signaling pathways also support its use in studying obesity and related disorders. -
Melanocortin Agonist
JLB2-110c is a potent melanocortin receptor agonist, specifically targeting the melanocortin-4 receptor (MC4R) with an EC50 of 0.34 nM. This compound demonstrates significant appetite suppressant effects in vivo, making it a valuable tool for research into obesity and metabolic disorders. Its ability to modulate energy homeostasis positions JLB2-110c as a key reagent for studies related to appetite regulation and weight management. -
Melanocortin Receptor Antagonist
(p-Iodo-Phe7)-ACTH (4-10) is a derivative of adrenocorticotrophic hormone (ACTH) that functions as a melanocortin receptor antagonist. This compound effectively inhibits the action of α-melanocyte-stimulating hormone (α-MSH), thereby reducing excessive grooming behavior observed in rat models. It serves as a valuable tool in research focused on the modulation of melanocortin signaling pathways and behaviors influenced by the central nervous system. -
Melanocortin 4 Receptor Agonist
RO27-3225 is a potent and selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating a 30-fold selectivity for MC4R over MC3R. This compound shows significant neuroprotective and anti-inflammatory effects, making it valuable for research in metabolic disorders, obesity, and neurodegenerative diseases. Its specific action on MC4R positions RO27-3225 as a key reagent for exploring the therapeutic potential of melanocortin signaling pathways. -
Melanocortin Receptor Inhibitor
Chlorophorin is an inhibitor of the Melanocortin Receptor, effectively reducing tyrosinase activity and melanogenesis. This compound demonstrates significant inhibition of α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells, making it valuable for research on pigmentation disorders and melanoma. Its mechanism of action provides insights into the modulation of skin pigmentation and potential therapeutic strategies. -
Melanocortin Receptor Agonist
ACTH (1-17) is a potent agonist of the human melanocortin 1 (MC1) receptor, exhibiting a Ki of 0.21 nM. This adrenocorticotropin analogue plays a critical role in modulating melanogenesis and has significant implications for research in skin pigmentation and endocrine regulation. Its efficacy makes it a valuable tool for studies focused on melanocortin signaling pathways and related therapeutic applications. -
MC4R Agonist
RY764 is a selective agonist for the melanocortin-4 receptor (MC4R), demonstrating an EC50 of 10 nM. This compound effectively reduces food intake and mitigates body weight gain in diet-induced obese (DIO) rat models. RY764 is suitable for research applications focusing on obesity and metabolic disorders. -
Melanogenesis Inhibitor
(R)-Lirinidine is an aporphine-type alkaloid derived from Nelumbo nucifera, known for its role as a melanogenesis inhibitor. With an IC50 value of 19.3 μM, it effectively reduces melanin production, making it valuable for research in skin pigmentation disorders. Additionally, (R)-Lirinidine exhibits cytotoxic effects at concentrations of 100 μM, highlighting its potential in various biological studies.
