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MC4-NN2-0453

Catalog No.: A61665
MC4R Agonist
MC4-NN2-0453 is a selective agonist of the melanocortin 4 receptor (MC4R) and serves as an analog of alpha-melanocyte-stimulating hormone (α-MSH). This compound is particularly relevant in the study of obesity, as it stimulates MC4R activity, which is known to play a crucial role in regulating appetite and energy expenditure. Its application in obesity research allows for better understanding of mechanisms that could lead to novel therapeutic strategies.
MC4-NN2-0453 1228015-10-8 MC4R Agonist
Grouped product items
Size Price Stock Qty
1mg
$385.00
In stock
5mg
$985.00
In stock
10mg
$1,510.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMC4-NN2-0453 is a selective agonist of the melanocortin 4 receptor (MC4R) and serves as an analog of alpha-melanocyte-stimulating hormone (α-MSH). This compound is particularly relevant in the study of obesity, as it stimulates MC4R activity, which is known to play a crucial role in regulating appetite and energy expenditure. Its application in obesity research allows for better understanding of mechanisms that could lead to novel therapeutic strategies.
Product Information
Catalog NumA61665
FormulaC96H146N28O25
Molecular Weight2092.36
CAS Number1228015-10-8
Sequence{Tetrazol-C16 acid-AEEA}-Gly-Ser-Gln-His-{Dap(NTA)}-{Nle}-Glu-{Hyp}-{dPhe}-Arg-Trp-Lys-NH2 (lactam bridge:Glu7-Lys12)
Sequence shortening{Tetrazol-C16 acid-AEEA}-GSQH-{Dap(NTA)}-{Nle}-E-{Hyp}-{dPhe}-RWK-NH2 (lactam bridge:Glu7-Lys12)
SMILESC(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC=CC=C4)NC(=O)[C@]5(N(C(=O)[C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC6=CN=CN6)NC([C@@H](NC([C@@H](NC(CNC(COCCOCCNC(CCCCCCCCCCCCCCCC=7NN=NN7)=O)=O)=O)CO)=O)CCC(N)=O)=O)=O)CNC(CN(CC(O)=O)CC(O)=O)=O)=O)CCCC)=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC3=O)C[C@H](O)C5)[H]
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GPCR/G Protein > Melanocortin Receptor