Fig. 1 · Structure
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HS024
MC4 Receptor Antagonist
HS024 is a selective antagonist of the melanocortin-4 (MC4) receptor, exhibiting inhibition constants (Kis) of 0.29 nM for MC4, 3.29 nM for MC5, 5.45 nM for MC3, and 18.6 nM for MC1. This compound is notable for its ability to enhance food intake, making it a valuable tool for research in metabolic disorders, appetite regulation, and obesity studies. HS024 may facilitate the exploration of pathways related to energy homeostasis and weight management.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 212370-59-7 |
| Applications | MC4 Receptor Antagonist |
| Formula | C58H79N19O10S2 |
| Molecular Weight | 1266.50 |
| SMILES | C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCC)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(=O)CNC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.