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RO27-3225 TFA

Catalog No.: A61643
Melanocortin 4 Receptor Agonist
RO27-3225 TFA is a selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating approximately 30-fold selectivity for MC4R over MC3R. This compound is recognized for its neuroprotective and anti-inflammatory properties, making it valuable in research related to metabolic regulation and inflammatory conditions. RO27-3225 TFA is suitable for studies focused on the role of MC4R in various physiological and pathological processes.
RO27-3225 TFA 1373926-49-8 Melanocortin 4 Receptor Agonist
Grouped product items
Size Price Stock Qty
5mg
$245.00
In stock
10mg
$405.00
In stock
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRO27-3225 TFA is a selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating approximately 30-fold selectivity for MC4R over MC3R. This compound is recognized for its neuroprotective and anti-inflammatory properties, making it valuable in research related to metabolic regulation and inflammatory conditions. RO27-3225 TFA is suitable for studies focused on the role of MC4R in various physiological and pathological processes.
Product Information
Catalog NumA61643
FormulaC39H52N12O6.xC2HF3O2
Molecular Weight784.91 (free base)
CAS Number1373926-49-8
Sequence{Butir}-His-{dPhe}-Arg-Trp-{Sar}-NH2
Sequence shortening{Butir}-H-{dPhe}-RW-{Sar}-NH2
SMILESOC(=O)C(F)(F)F.CCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)CC(N)=O
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GPCR/G Protein > Melanocortin Receptor