PG-931 is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting an IC50 of 0.58 nM, while demonstrating selective activity against the human MC3R and MC5R with IC50 values of 55 nM and 2.4 nM, respectively. This compound has shown significant biological activity in reversing haemorrhagic shock and mitigating multiple organ damage in vivo. PG-931 is valuable for research applications focused on obesity, metabolic disorders, and neurodegenerative diseases involving melanocortin signaling pathways.
PG-931 is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting an IC50 of 0.58 nM, while demonstrating selective activity against the human MC3R and MC5R with IC50 values of 55 nM and 2.4 nM, respectively. This compound has shown significant biological activity in reversing haemorrhagic shock and mitigating multiple organ damage in vivo. PG-931 is valuable for research applications focused on obesity, metabolic disorders, and neurodegenerative diseases involving melanocortin signaling pathways.
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