Fig. 1 · Structure
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PG-931
Melanocortin 4 Receptor Agonist
PG-931 is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting an IC50 of 0.58 nM, while demonstrating selective activity against the human MC3R and MC5R with IC50 values of 55 nM and 2.4 nM, respectively. This compound has shown significant biological activity in reversing haemorrhagic shock and mitigating multiple organ damage in vivo. PG-931 is valuable for research applications focused on obesity, metabolic disorders, and neurodegenerative diseases involving melanocortin signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 667430-81-1 |
| Applications | Melanocortin 4 Receptor Agonist |
| Formula | C59H85N15O11 |
| Molecular Weight | 1180.40 |
| SMILES | C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@H](C(=O)N4[C@H](C(N[C@@H]([C@@H](C)C)C(N)=O)=O)CCC4)CCCCNC(=O)C[C@H](NC([C@H](CCCC)NC(C)=O)=O)C(=O)N5[C@](C(=O)N[C@H](CC6=CC=CC=C6)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N3)(CCC5)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.