Fig. 1 · Structure
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GPS1573
MC2R Antagonist
GPS1573 is a noncompetitive antagonist of the melanocortin type 2 receptor (MC2R), exhibiting dose-dependent inhibition of adrenocorticotropic hormone (ACTH)-induced MC2R activity with an IC50 value of 66 nM. This compound is particularly valuable in research focused on Cushing's disease, given its high selectivity for MC2R antagonism. Its properties make GPS1573 an important tool for studying adrenal regulation and related endocrine disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2445822-54-6 |
| Applications | MC2R Antagonist |
| Formula | C86H138N28O14 |
| Molecular Weight | 1788.20 |
| SMILES | C([C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)=O)C(C)C)=O)C)=O)CCCCN)=O)=O)NC([C@@H](NC([C@H](NC(=O)[C@H]2N(C([C@H](CCCC)N)=O)CCC2)CC3=CC=CC=C3)=O)CCCNC(=N)N)=O)C=4C=5C(NC4)=CC=CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.