Fig. 1 · Structure
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D-Trp8-γ-MSH
MC3 Agonist
[D-Trp8]-γ-MSH is a selective agonist of the melanocortin 3 (MC3) receptor, exhibiting an IC50 of 6.7 nM in CHO cells. This compound also demonstrates activity against the MC4 and MC5 receptors, with IC50 values of 600 nM and 340 nM, respectively. [D-Trp8]-γ-MSH is implicated in research applications related to inflammatory disorders, showing potential neuroprotective effects in conditions such as rheumatoid arthritis and colitis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 321351-81-9 |
| Applications | MC3 Agonist |
| Formula | C74H99N21O16S |
| Molecular Weight | 1570.77 |
| SMILES | C([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC(CNC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)N)=O)C(C)C)=O)CCSC)=O)=O)=O)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(NCC(O)=O)=O)=O)CCCNC(=N)N)=O)CC(O)=O)=O)C=5C=6C(NC5)=CC=CC6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.