Catalog No.
Product Name
Application
Product Information
Citations
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NPY Y2 Receptor Antagonist
SF 11 is a potent antagonist of the neuropeptide Y Y2 receptor, exhibiting an IC50 value of 199 nM. This compound demonstrates antidepressant-like activity, making it a valuable tool for research into mood disorders and neuropharmacology. Its ability to penetrate the blood-brain barrier enhances its application in studies related to central nervous system functions and therapeutic interventions. -
NPY2R Agonist
Nisotirostide is a selective NPY2 receptor agonist that mimics the action of peptide YY (PYY). This compound has demonstrated the ability to inhibit appetite, making it a valuable tool for researching obesity and metabolic disorders such as diabetes. Its application in these areas may provide insights into therapeutic strategies for appetite regulation and weight management. -
NPY Y5 Receptor Antagonist
NPY5RA-972 is a potent and selective antagonist of the neuropeptide Y (NPY) Y5 receptor, effectively penetrating the central nervous system (CNS). This compound inhibits the feeding behavior mediated by NPY Y5 receptor activation, making it a valuable tool for research into appetite regulation and obesity-related studies. Its oral bioavailability further enhances its utility for in vivo applications in neuroscience and metabolic research. -
NPY Cardiac Receptor Antagonist
Neuropeptide Y (18-36) (porcine) serves as a competitive antagonist of neuropeptide Y (NPY) cardiac receptors. With an IC50 value of 158 nM and a Ki value of 140 nM, this compound effectively inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner. It is a valuable reagent for research focused on the pathophysiology and therapeutic interventions in congestive heart failure. -
GPR55 Ligand
L-α-lysophosphatidylinositol (Soy) sodium is a potent endogenous ligand for the GPR55 receptor. As a lysophospholipid and endocannabinoid neurotransmitter, it plays a crucial role in various signaling pathways. It is primarily utilized in research applications focusing on cannabinoid receptor modulation, cell signaling processes, and neurobiology studies. -
Guanylate Cyclase-C Agonist
Plecanatide is a guanylate cyclase-C (GC-C) receptor agonist, functioning as an analogue of Uroguanylin. It effectively activates GC-C receptors, leading to the stimulation of cGMP synthesis, with an EC50 of 190 nM in T84 cell assays. Additionally, Plecanatide demonstrates anti-inflammatory activity in murine colitis models, making it useful for research into gastrointestinal disorders and related inflammatory conditions. -
Guanylate Cyclase Agonist
Linaclotide acetate is a potent and selective agonist of guanylate cyclase C, primarily involved in the regulation of intestinal fluid secretion. This compound enhances chloride and bicarbonate secretion, promoting gastrointestinal fluid accumulation and facilitating movement within the intestines. Linaclotide acetate is commonly utilized in research focused on gastrointestinal disorders, specifically for studying mechanisms and treatments related to constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. -
Guanylate Cyclase Inhibitor
Guanylate cyclase-IN-1 is a potent inhibitor of guanylate cyclase, a crucial enzyme involved in the regulation of intracellular signaling pathways. This compound exhibits significant biological activity by modulating nitric oxide signaling, making it a valuable tool for the study of cardiovascular diseases. Its applications extend to investigating the physiological and pathological roles of guanylate cyclase in various biological processes. -
Guanylate Cyclase Activator
Prepro-ANF (56-92), human is a precursor of the atrial natriuretic factor and functions as a guanylate cyclase activator. This peptide enhances the activity of particulate guanylate cyclase within renal membranes and units, playing a critical role in the regulation of renal function and blood pressure homeostasis. Its application in research includes studies on cardiovascular and renal physiology, as well as investigations into natriuretic signaling pathways. -
Diguanylate Cyclases Inhibitor
Ebselen oxide is a selenone analogue that serves as a potent inhibitor of diguanylate cyclases (DGCs). By covalently modifying DGCs, it disrupts c-di-GMP-receptor interactions and subsequently decreases DGC activity. Additionally, Ebselen oxide demonstrates antibacterial properties by inhibiting alginate production in Pseudomonas aeruginosa, with an IC50 of 14 μM. It also exhibits inhibitory activity against various histone deacetylases (HDAC1 to HDAC9), with IC50 values ranging from 0.2 to 4.7 μM, making it useful for research involving epigenetic regulation. -
Intestinal Guanylate Cyclase Activator
Guanylin (human) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. It primarily regulates electrolyte and water transport in intestinal and renal epithelia via a cyclic GMP-dependent mechanism. This endogenous peptide plays a crucial role in maintaining fluid homeostasis and is vital in studies related to gastrointestinal function and renal physiology. Research applications include investigating gastrointestinal disorders and kidney function modulation. -
Guanylate Cyclase Activator
Mosliciguat is a potent guanylate cyclase activator that enhances nitric oxide signaling through the stimulation of soluble guanylate cyclase. This compound exhibits key biological activities, including vasodilation and reduced blood pressure, making it relevant for cardiovascular research. Mosliciguat is primarily utilized in studies assessing pulmonary hypertension and related disorders, providing valuable insights into endothelial function and smooth muscle relaxation. -
Soluble Guanylate Cyclase Activator
BI 703704 is a potent soluble guanylate cyclase (sGC) activator that enhances intracellular signaling pathways through increased cGMP levels. It has demonstrated efficacy in inhibiting the progression of diabetic nephropathy in the ZSF1 rat model, making it a valuable tool for studying renal complications associated with diabetes. This compound is useful for research on cardiovascular and metabolic diseases, particularly those involving sGC modulation. -
Guanylate Cyclase Activator
Nurandociguatum is a guanylate cyclase activator that enhances intracellular cGMP levels, leading to vasodilation and modulation of nitric oxide signaling. This compound is primarily utilized in cardiovascular research, particularly in studies investigating pulmonary hypertension and heart failure mechanisms. Its ability to stimulate guanylate cyclase makes it a valuable tool for exploring therapeutic strategies targeting vascular relaxation and nitric oxide pathways. -
Guanylate Cyclase Activator
Guanylin (mouse, rat) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. This compound plays a crucial role in regulating electrolyte and fluid balance in the intestine. Guanylin is commonly used in research related to diarrheal diseases and gastrointestinal disorders, providing insights into mechanisms of fluid secretion and absorption. -
Soluble Guanylate Cyclase Agonist
IWP-051 is an agonist for soluble guanylate cyclase, with an EC50 of 290 nM. It effectively stimulates the production of cyclic guanosine monophosphate (cGMP) and shows a synergistic effect with nitric oxide (NO). This compound is suitable for research focusing on cardiovascular function, smooth muscle relaxation, and other cGMP-related signaling pathways. Moreover, IWP-051 demonstrates favorable pharmacokinetic properties in rat models, making it a valuable tool for in vivo studies. -
Guanylate Cyclase Inhibitor
2-Chloro-ATP functions as a soluble guanylate cyclase inhibitor, impacting intracellular signaling pathways. This compound elevates intracellular calcium concentrations at low concentrations, utilizing a mechanism that does not rely on inositol phosphate production. It is valuable for studies investigating the role of guanylate cyclase in various physiological and pathological conditions. Researchers can utilize 2-Chloro-ATP to understand the modulation of calcium signaling in cellular processes. -
Histamine H1 Receptor Antagonist
Terfenadine N-oxide is a histamine H1 receptor antagonist with an IC50 value of 2.73 μM, also exhibiting inhibition of the hERG potassium channel with an IC50 of 0.698 μM. This compound is valuable for investigating histamine-related allergic diseases and the role of hERG channels in arrhythmias. Its dual activity makes it a useful tool for research in pharmacology and toxicology related to allergic responses and cardiac rhythm disturbances. -
ICMT Inhibitor
ICMT-IN-1 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.0013 μM. This compound has been shown to effectively induce the accumulation of ICMT in the cytoplasm of HCT-116 cells. Additionally, ICMT-IN-1 exhibits significant antiproliferative activity against various cancer cell lines that express K-Ras and N-Ras, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-30 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.27 μM. This compound is essential for studying the role of ICMT in various biological processes, including protein modification and signaling pathways. Its inhibition can be utilized in research focused on cancer, neurodegeneration, and other diseases associated with abnormal protein prenylation. -
ICMT Inhibitor
ICMT-IN-28 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 0.008 μM. This compound effectively disrupts the ICMT-mediated methylation of isoprenylated proteins, playing a critical role in cellular signaling pathways. ICMT-IN-28 is utilized in studies investigating the regulation of protein function and has potential applications in cancer research and other areas of cell biology. -
ICMT Inhibitor
ICMT-IN-52 is a specific inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.052 μM. This compound plays a crucial role in research on post-translational modifications and protein maturation related to oncogenesis and cellular signaling. Its ability to effectively inhibit ICMT makes it a valuable tool for studying the biological implications of ICMT activity in various disease models. -
ICMT Inhibitor
ICMT-IN-5 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.3 μM. This compound modulates protein localization and activity through the inhibition of ICMT, making it valuable for studying signal transduction pathways and post-translational modifications. ICMT-IN-5 is suitable for research applications focused on cancer biology, neurobiology, and other fields where ICMT plays a critical role in regulating protein function. -
ICMT Inhibitor
ICMT-IN-34 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.17 μM. This compound exhibits significant biological activity in the modulation of protein methylation, influencing various cellular processes. It is valuable for research applications aimed at elucidating the roles of ICMT in signal transduction and cancer biology. -
ICMT Inhibitor
ICMT-IN-51 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.55 μM. This compound is essential for studying the role of ICMT in post-translational modifications of proteins, particularly in signaling pathways related to cancer and other diseases. Its utility in biochemical assays makes it a valuable tool for researchers investigating the therapeutic potential of ICMT modulation. -
ICMT Inhibitor
ICMT-IN-7 is a potent inhibitor of isoprenylcysteine methyltransferase (ICMT), with an IC50 of 0.015 μM. This compound effectively induces the accumulation of ICMT in the cytoplasm of HCT-116 cells and demonstrates significant inhibitory effects on the proliferation of various cancer cell lines that express K-Ras and N-Ras. ICMT-IN-7 is valuable for research applications targeting ICMT-related pathways in cancer biology. -
ICMT Inhibitor
ICMT-IN-6 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.09 μM. This compound effectively disrupts ICMT activity, which plays a critical role in protein prenylation processes. ICMT-IN-6 is valuable for studying the biological implications of ICMT inhibition and its potential therapeutic applications in cancer and other diseases involving dysregulated protein prenylation. -
ICMT Inhibitor
ICMT-IN-50 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), with an IC50 value of 0.31 μM. This compound is utilized in research to investigate the role of ICMT in post-translational modifications and its impact on protein function and signaling pathways. Suitable for studies involving cancer biology and therapeutic development, ICMT-IN-50 provides a valuable tool for understanding ICMT's biological significance. -
ICMT Inhibitor
ICMT-IN-24 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.19 μM. This compound is utilized in research to explore the role of ICMT in post-translational modifications and its implications in various cellular processes. Its ability to inhibit ICMT makes it a valuable tool for studying protein activity and signaling pathways related to cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-15 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.032 μM. By blocking the activity of ICMT, this compound disrupts post-translational modifications of proteins involved in signaling pathways. ICMT-IN-15 is utilized in research focused on understanding the role of protein methylation in cellular processes and disease mechanisms, making it a valuable tool for studies in cancer, neurobiology, and other fields. -
ICMT Inhibitor
ICMT-IN-13 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.47 μM. This compound is crucial for studying the role of ICMT in post-translational modifications of proteins, particularly in oncogenic signaling pathways. Its application in chemical biology can provide insights into the regulation of protein function and potential therapeutic strategies targeting cancer progression. -
ICMT Inhibitor
ICMT-IN-46 is an inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.556 μM. This compound plays a critical role in modulating protein prenylation processes, impacting various signaling pathways. It is suitable for research applications focused on cellular signaling, protein modification, and the investigation of diseases where ICMT activity is a key factor. -
ICMT Inhibitor
ICMT-IN-37 is a selective inhibitor of Isoprenylcysteine methyltransferase (ICMT), exhibiting an IC50 of 0.308 μM. This compound is instrumental for investigating the role of ICMT in various cellular processes, including protein localization and signaling pathways. Its application extends to studies on post-translational modifications and the functional implications of ICMT inhibition in cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-27 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.1 μM. This compound effectively disrupts the post-translational modification of proteins that rely on ICMT activity. It is primarily utilized in studies involving protein regulation, signal transduction, and cancer research, enabling scientists to explore the role of ICMT in various biological processes. -
ICMT Inhibitor
ICMT-IN-20 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.682 μM. This compound is instrumental in the study of post-translational modifications in proteins, facilitating research into their role in various cellular processes. ICMT-IN-20 is applicable in investigations of signal transduction pathways and may contribute to the understanding of certain diseases where ICMT activity is disrupted. -
ICMT Inhibitor
ICMT-IN-44 is a selective inhibitor of isopeptidase cyseel methyltransferase (ICMT) with an IC50 value of 0.167 μM. This compound is designed to disrupt the methylation of cyseel proteins, thereby influencing post-translational modifications and cellular signaling pathways. ICMT-IN-44 is valuable in biochemical research for studying the role of ICMT in various physiological and pathological processes, making it a useful tool in drug discovery and development. -
ICMT Inhibitor
ICMT-IN-36 is a specific inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), showing an IC50 value of 0.181 μM. This compound is valuable for researchers investigating ICMT’s role in protein modification and its implications in cancer and other diseases. Its applications include studying protein stability and signaling pathways related to post-translational modifications. -
ICMT Inhibitor
ICMT-IN-12 is a selective inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT) with an IC50 value of 0.42 μM. This compound demonstrates important biological activity by blocking ICMT-mediated post-translational modifications, which play a crucial role in protein function and stability. ICMT-IN-12 is applicable in studies focusing on signaling pathways and cellular processes influenced by protein prenylation, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-8 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.652 μM. This compound is primarily utilized in research applications focusing on protein prenylation and related signaling pathways. Investigating ICMT's role can provide insights into its potential implications in cancer and other diseases linked to dysregulated protein modification. -
ICMT Inhibitor
ICMT-IN-21 is a potent inhibitor of isoprenylcysteine O-methyltransferase (ICMT), with an IC50 value of 8.8 μM. This compound features a sulfonamide-modified farnesyl cysteine structure, with key farnesyl and carboxylic acid motifs critical for its inhibitory activity. ICMT-IN-21 is valuable for investigating the role of ICMT in post-translational modifications and cellular signaling processes, providing insights into potential therapeutic interventions. -
ICMT Inhibitor
ICMT-IN-17 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) with an IC50 of 0.38 μM. This compound disrupts the methylation of isoprenylated proteins, which is crucial for their membrane localization and function. ICMT-IN-17 serves as a valuable tool in research aimed at understanding the role of protein methylation in various cellular processes and its implications in disease states. -
ICMT Inhibitor
ICMT-IN-26 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.36 μM. This compound is utilized in biochemical research to investigate the role of ICMT in protein modification and signal transduction pathways. Its inhibition profile makes it a valuable tool for studying diseases associated with dysregulated protein methylation. -
ICMT Inhibitor
ICMT-IN-16 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.131 μM. This compound is utilized in research to elucidate the role of ICMT in protein modification and signal transduction pathways. Its inhibition can provide insights into various cellular processes, making it a valuable tool for studies focused on cancer biology and other related fields. -
ICMT Inhibitor
ICMT-IN-41 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) with an IC50 of 0.069 μM. This compound has demonstrated significant potential in regulating post-translational modifications of proteins, making it valuable for studies related to cell signaling and protein stability. It is particularly relevant in research focused on cancer biology and the roles of protein modification in disease pathways. -
ICMT Inhibitor
ICMT-IN-31 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.0038 μM. This compound effectively disrupts protein farnesylation, influencing cellular processes such as signal transduction and protein localization. ICMT-IN-31 is particularly valuable for research in cancer biology and the study of post-translational modifications. -
ICMT Inhibitor
ICMT-IN-54 is an adamantyl analogue that functions as an inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 12.4 μM. This compound effectively inhibits the methylation of BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) in Saccharomyces cerevisiae expressing ICMT, thereby demonstrating its potential to interfere with ICMT-mediated methylation processes. ICMT-IN-54 is a valuable tool for research into the roles of ICMT in cellular signaling and protein modification. -
ICMT Inhibitor
ICMT-IN-18 is a potent inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT), demonstrating an IC50 of 0.066 μM. This compound is valuable for investigating the role of ICMT in post-translational modifications and protein processing. Its applications extend to studies of cancer biology and signal transduction pathways where altered protein function may influence disease progression. -
ICMT Inhibitor
ICMT-IN-40 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.031 μM. This compound disrupts protein modification by inhibiting cysteine methylation, a critical process for the function and stability of various proteins involved in cellular signaling. ICMT-IN-40 is useful in research applications focused on studying protein prenylation and its implications in cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-11 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.031 μM. This compound is valuable for research into protein post-translational modifications and their implications in various cellular processes. It is particularly useful in studies focused on cancer biology and signaling pathways involving prenylated proteins. -
ICMT Inhibitor
ICMT-IN-29 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.019 μM. This compound exhibits significant inhibitory activity and can be utilized in research applications aimed at elucidating the role of ICMT in protein modification and cellular signaling pathways. Its ability to selectively inhibit ICMT makes it a valuable tool for studying the implications of isoprenylation in various biological contexts.
