Fig. 1 · Structure
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AM211 sodium
Prostaglandin Receptor Antagonist
AM211 sodium is a selective and potent antagonist of the prostaglandin D2 receptor type 2 (DP2), exhibiting an IC50 of 4.9 nM for human DP2 and similar efficacy in mouse, guinea pig, and rat models with IC50s of 7.8 nM, 4.9 nM, and 10.4 nM, respectively. Its oral bioavailability makes it an important tool for studying the role of DP2 in various biological processes, including inflammation and allergic responses. AM211 sodium is suitable for research applications investigating the modulation of prostaglandin signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1263077-74-2 |
| Applications | Prostaglandin Receptor Antagonist |
| Formula | C27H26F3N2NaO4 |
| Molecular Weight | 522.49 |
| SMILES | O=C(O[Na])CC1=CC(C2=CC=C(C(F)(F)F)C=C2CN(CC)C(NCC3=CC=CC=C3)=O)=C(OC)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.