Fig. 1 · Structure
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ONO-AE3-208 sodium salt
EP4 Receptor Antagonist
ONO-AE3-208 sodium salt is a selective antagonist of the EP4 receptor, exhibiting a Ki value of 1.3 nM, which demonstrates its strong binding affinity. This compound has minimal effect on EP3, FP, and TP receptors, with Ki values of 30 nM, 790 nM, and 2400 nM, respectively. ONO-AE3-208 sodium salt has shown significant biological activity in inhibiting cell invasion, migration, and metastasis in prostate cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2309931-05-1 |
| Applications | EP4 Receptor Antagonist |
| Formula | C24H20FN2NaO3 |
| Molecular Weight | 426.42 |
| Synonyms | AE 3-208 sodium salt |
| SMILES | FC1=CC=C(C2=CC=CC=C21)C(C)C(NC3=CC(C#N)=CC=C3CCCC(O[Na])=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.